Background and purpose: Anal squamous cell carcinoma is primarily treated with radiotherapy (RT), but the optimal RT dose for anal tumours of different sizes is not known. The purpose of this study was to identify determinants for local tumour control probability (LTCP). Material and methods: From a large Nordic database 901 patients who received RT for anal cancer between 2000 and 2007 were selec

Following upon previous work on the 1630 Ma Melville Bugt Dyke Swarm (MBDS) along the NW coast of Greenland, this paper confirms its proposed continuation in SE Greenland, into an extraordinary >2000 km long trans-Greenlandic dyke swarm. This correlation is not only based on the swarm's continuous pattern, but now also by a matching 1630 ± 4 Ma U-Pb baddeleyite age determination and similar bulk r

How aerodynamic power required for animal flight varies with flight speed determines optimal speeds during foraging and migratory flight. Despite its relevance, aerodynamic power provides an elusive quantity to measure directly in animal flight. Here, we determine the aerodynamic power from wake velocity fields, measured using tomographical particle image velocimetry, of pied flycatchers flying fr

There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington's disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to summarise studies on biofluid markers for HD. A PubMed search was performed to review literature with regard to candidate saliva, urine, blood and cerebrospinal f

The structure of dispersions of TEMPO-oxidised cellulose nanofibrils (OCNF), at various concentrations, in water and in NaCl aqueous solutions, was probed using small angle X-ray scattering (SAXS). OCNF are modelled as rod-like particles with an elliptical cross-section of 10 nm and a length greater than 100 nm. As OCNF concentration increases above 1.5 wt%, repulsive interactions between fibrils

The formation of amyloid fibrils is a central phenomenon in the progressive pathology of many neurodegenerative diseases, as well as in the fabrication of functional materials. Several different molecular processes acting in concert are responsible for the formation of amyloid fibrils from monomeric protein in solution. Here, we describe a method to determine which microscopic processes drive the

Background: A scientifically sound validated foot and ankle specific score validated ab initio for different languages is missing. The aim of a project of the European Foot and Ankle Society (EFAS) was to develop, validate, and publish a new score(the EFAS-Score) for different European languages. Methods: The EFAS Score was developed and validated in three stages: (1) item (question) identificatio

Land-Use Change and Terrestrial Predator–Prey Networks Land-use change, here defined as the conversion of one land-use type into another (e.g., forest to arable land), affects biodiversity and biotic interactions worldwide (Sala et al., 2000). Although there has been large regional variation in the extent of agricultural expansion and abandonment in Europe in the past 50 years (Rabbinge and van Di

Increasingly, prostitution and other activities in the sex industries have been conceptualised as forms of labour, or at least as income-generating activities. As labour, these activities are exposed to particular risks with respect to health, working conditions, exploitation and stigmatisation. However, research on the actual conditions and circumstances existing in these markets, remains limited

Background: Abdominal obesity is on the increase worldwide and ethnic minority groups are at high risk. However, studies of the underlying causes are scarce. The aims of this study were to investigate the prevalence of abdominal obesity and to identify metabolic, lifestyle and socio-demographic risk factors associated with abdominal obesity in male and female residents of Malmö, a city in southern

Background: Metastatic castration resistant prostate cancer (mCRPC) is a bone dominant lethal disease. Progression in bone scan of mCRPC disease is assessed with the Prostate Cancer Working Group (PCWG) two and three criteria, which relies on the appearance of two or more new lesions. There is an unmet need for a quantitative assessment that can build on the current progression criteria. This thes

Sepsis is a common and often deadly systemic response to an infection, usually caused by bacteria. The gold standard for finding the causing pathogen in a blood sample is blood culture, which may take hours to days. Shortening the time to diagnosis would significantly reduce mortality. To replace the time-consuming blood culture we are developing a method to directly separate bacteria from red and

Recent evidence suggests that cholera toxin might have multiple functions regarding the ability to regulate the immune system. However, it is unknown whether subsequent administration of cholera vaccine might affect the mortality rate in patients with prostate cancer. Here we report that patients in Sweden, who were diagnosed with prostate cancer between July 2005 and December 2014 and used choler

Bixin is one of the most used yellow-orange food colorants in the food industry. The polyene chain of bixin makes it highly hydrophobic and less suitable for water-based food formulations. Lipase-catalyzed reactions of bixin with sorbitol were studied to synthesize a new derivative of bixin with potential hydrophilic properties. Interestingly, we show that the lipase-catalyzed reaction of bixin le

Dissolved organic carbon (DOC) loading is rarely estimated in tropical watersheds. This study quantifies DOC loading in the Rukarara River Watershed (RRW), a Rwandan tropical forest and agricultural watershed, and evaluates its relationship with hydrological factors, land use and land cover (LULC), and topography to better understand the impact of stream DOC export on watershed carbon budgets. The