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In Search of Process Innovations : The Role of Search Depth, Search Breadth, and the Industry Environment

Although a significant corpus of work focuses on the impact of search strategies on product innovations, we have a limited understanding of search strategies for process innovations, including the potential role of the industry environment. Process innovations are central to improving a firm’s productivity and contributing to efficiency and gross domestic product growth. As a result of the complex

Regulation of rod phototransduction machinery by ciliary neurotrophic factor

Ciliary neurotrophic factor (CNTF) promotes photoreceptor survival but also suppresses electroretinogram (ERG) responses. This has caused concerns about whether CNTF is detrimental to the function of photoreceptors because it is considered to be a potential treatment for retinal degenerative disorders. Here we report that the suppression of ERG responses is attributable to negative regulation of t

RS-1 Gene Delivery to an Adult Rs1h Knockout Mouse Model Restores ERG b-Wave with Reversal of the Electronegative Waveform of X-Linked Retinoschisis

PURPOSE: To create and evaluate a mouse model of human X-linked juvenile retinoschisis (XLRS) and then investigate whether supplementing with the retinoschisin protein by gene delivery can reverse the abnormal "electronegative" electroretinogram (ERG) retinal response.METHODS: An X-linked retinoschisis mouse (Rs1h-KO) model was created by substituting a neomycin resistance cassette for exon 1 and

The Ethos of History : Time and Responsibility

At a time when rapidly evolving technologies, political turmoil, and the tensions inherent in multiculturalism and globalization are reshaping historical consciousness, what is the proper role for historians and their work? By way of an answer, the contributors to this volume offer up an illuminating collective meditation on the idea of ethos and its relevance for historical practice. These intell

Hedwig Eleonora, Lund University, and the Learned

As a queen, a woman in the pre-modern period could interact with the learned society in several ways, either as a learned woman, or - like Hedwig Eleonora - by patronizing and participating actively in the intellectual culture of her time as a donor, an employer, and a foundress of learned institutions. In doing this, she sometimes accentuated her personal sympathies, be they in history, theology,

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic mutations in BRCA1 and/or BRCA2 (BRCA1/BRCA2) also confer selective sensitivity to PARP inhibitors. Thus, assays to detect BRCA1/BRCA2-deficient tumors have been sought. Recently,