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PURPOSE: A randomized clinical trial was conducted to evaluate the impact of a gluten-free diet (GFD) on β-cell function and glucose tolerance in persons with multiple islet autoantibodies.METHODS: Individuals (n = 59; median age 11 years) with multiple islet autoantibodies were recruited to a randomized clinical trial between April 2016 and April 2021. The participants were randomized to a GFD (n

We comment on the consequences of the target article for language evolution research. We propose that the default assumption should be that of language-readiness in extinct hominins, and the integration of different types of available evidence from multiple disciplines should be used to assess the likely extent of the realization of this readiness. The role of archaeological evidence should be rec

Objectives To study neutrophil gelatinase-associated lipocalin (NGAL) levels in peripheral blood in SLE, and to propose a mechanism by which neutrophils secrete NGAL on stimulation with immune complexes (IC). Methods NGAL was measured by ELISA in two independent Swedish SLE cohorts acting as exploratory and validation cohort (n=124 and n=308, respectively), disease controls (n=38) and healthy cont

Many artificial systems simulate the physiological state of the human gastrointestinal tract (GIT) and its separate compartments. These systems have the biorelevant media and imitate the physical forces and transit times of the GIT compartments, however, they lack the food-related and within-compartmental regulations and thus issues with translation of the data obtained to clinics arise. We aimed

It is increasingly recognized that feelings of incompleteness and not just right experiences are important emotional and sensory processes underpinning obsessive-compulsive disorder (OCD). Such experiences refer to uncomfortable sensations that something is not right or not in its proper order, and they are typically accompanied by urges to perform behavioral or mental actions until it feels just

The rationale for this Editorial and the Special Feature Issue (SFI) it introduces is the conviction that money and monetary system design are largely overlooked in debates concerning sustainability. Modern monies (i.e., conventional sovereign fiat currencies) and aspects of them (such as their issuance, functions, and features) tend to be taken for granted as self-evident foundations for the orga

Review of Jan Bruér (2024), Jazz i Sverige – de första hundra åren [Jazz in Sweden – the first hundred years].

En biografi om Amanda Brandt (1833–1915), dotter till en hovslagare och en fattig föräldralös från Västerås, Sverige, som levde ett extraordinärt liv. När hon var sjutton år försökte en av Sveriges mest berömda författare kasta misstankar på henne för en stöld som han själv hade begått. Hon turnerade i Tyskland som sopran och skådespelerska. Vid 27 års ålder fick hon sitt första barn med den världA biography of Amanda Brandt (1833–1915), a farrier’s daughter and a poor orphan from Västerås, Sweden, who led an extraordinary life. When she was seventeen, one of Sweden’s most famous authors tried to cast suspicion on her for a theft he himself had committed. She toured Germany as a soprano singer and actress. At 27, she had her first child with the world-famous African American Shakespearean

Background: Adverse skin reactions to continuous glucose monitors (CGMs) and devices for continuous subcutaneous insulin infusions (CSIIs) (“diabetes medical devices” (MDs)) are well known. However, epidemiological studies on prevalence and skin rash details are lacking. The objective of this study was to describe the prevalence and details of skin rash to diabetes MDs in adults with type 1 diabet

We report three cases of contact allergy to a mislabelled hair dye product. A hair dye product labelled as p-phenylenediamine-free has been found to contain p-phenylenediamine by a chemical analysis at the level above the limits allowed in the product.

Robustness is the ability of systems to survive unforeseen or unusual circumstances, allowing them to withstand local damage and redistribute stresses to reduce disruptions from component failures. It may be measured by calculating the probability of system failure when specific components fail, compared to the overall system reliability. However, treating robustness and reliability as opposites c

Aim: To describe the prevalence and incidence of pain, identify prognostic factors for pain, determine psychometric properties of tools to assess pain, and evaluate effectiveness of interventions for reducing pain among adults with cerebral palsy (CP). Method: Six databases were searched to identify studies published since 1990 in any language that met eligibility criteria defined for each objecti

With the ongoing developments in the field of anti-amyloid therapy for Alzheimer’s disease, it is crucial to better understand the longitudinal associations between amyloid-β deposition and altered network activity in the living human brain. We included 110 cognitively unimpaired individuals (67.9 ± 5.7 years), who underwent [18F]flutemetamol (amyloid-β)-PET imaging and resting-state magnetoenceph

Current trends aim at improving the surface integrity of aerospace Ni-based superalloys by reducing the temperature rise in the cutting zone in order to minimize tool wear, as well as reducing the thermally induced tensile residual stresses on the machined surface. The manufacturing industry is also driven by developing high performance sustainable machining processes. Cryogenic machining (CM) usi

The emergence of cyber mistreatment among frontline workers in their digital interactions with customers, clients and patients represents a significant but relatively new work environment risk within the service sector. Human resource management has a key role in digital transformation, which includes securing safe and healthy workplaces and fostering sustainable practices for handling cyber mistr

External quality assessment (EQA) schemes for pathology are essential, yet large/international programmes do not assess morphology-based biomarkers or address local/regional needs. This study outlines bottom-up initiated, flexible Swedish Digital Pathology EQA rounds for breast pathology, and presents results from the 2021 and 2023 rounds. Six breast carcinoma cases were selected for each EQA roun

Glycolipid-lectin-driven endocytosis controls the formation of clathrin-independent carriers and the internalization of various cargos such as β1 integrin. Whether this process is regulated in a dynamic manner remained unexplored. Here we demonstrate that, within minutes, the epidermal growth factor triggers the galectin-driven endocytosis of cell-surface glycoproteins, such as integrins, that are