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Sequential chemotherapy/radiotherapy was comparable with concurrent chemoradiotherapy for stage I/II NK/T-cell lymphoma

Background: In stage I/II natural killer (NK)/T-cell lymphoma, concurrent chemoradiotherapy (CCRT) had previously been shown to result in superior outcome compared with anthracycline-containing regimens, which have since been considered ineffective. The role of CCRT in comparison with approaches employing nonanthracycline-containing chemotherapy (CT) and sequential radiotherapy (RT) in such patien

Changes in blood volume shunting in patients with atrial septal defects : Assessment of heart function with cardiovascular magnetic resonance during dobutamine stress

Background: The purpose of this study was to determine the effect of stress on left-to-right shunting in patients with atrial septal defect (ASD) and to investigate if the degree of shunting, cardiac output (CO), and right ventricular (RV) volumes are related to exercise capacity. Methods: Twenty-six patients with a secundum ASD and 16 healthy volunteers were studied with rest/stress cardiac magne

Which patients with moderate hypoxemia benefit from long-term oxygen therapy? Ways forward

Long-term oxygen therapy (LTOT) improves prognosis in patients with COPD and chronic severe hypoxemia. The efficacy in moderate hypoxemia (tension of arterial oxygen; on air, 7.4−8.0 kPa) was questioned by a recent large trial. We reviewed the evidence to date (five randomized trials; 1,191 participants, all with COPD). Based on the current evidence, the survival time may be improved in patients w

Rätt kopplat EKG - En förutsättning för rätt diagnos

Different lead misplacements may present with typical ECG changes, which may influence the management of the patient, if not identified and corrected. It is important, both for the ECG technician and for the interpreting physician, to recognize typical patterns of lead misplacement to avoid misinterpretation of the ECG.

An Intense Attosecond Light Source - Towards Extreme Ultraviolet Pump-Probe Experiments

This thesis presents important steps towards performing high-intensity attosecond pump-probe experiments at the Lund high-intensity extreme ultraviolet (XUV) beamline, which followed two complementary paths: maximization of the XUV intensity available in the interaction region with a gas target, and providing attosecond temporal resolution.To maximize the energy of the XUV pulses generated via hig

Is human classification by experienced untrained observers a gold standard in fixation detection?

Despite early reports and the contemporary consensus on microsaccades as purely binocular phenomena, recent work has proposed not only the existence of monocular microsaccades, but also that they serve functional purposes. We take a critical look at the detection of monocular microsaccades from a signal perspective, using raw data and a state-of-the-art, video-based eye tracker. In agreement with

Biochemistry and adaptive colouration of an exceptionally preserved juvenile fossil sea turtle

The holotype (MHM-K2) of the Eocene cheloniine Tasbacka danica is arguably one of the best preserved juvenile fossil sea turtles on record. Notwithstanding compactional flattening, the specimen is virtually intact, comprising a fully articulated skeleton exposed in dorsal view. MHM-K2 also preserves, with great fidelity, soft tissue traces visible as a sharply delineated carbon film around the bon

Response to radiotherapy after breast-conserving surgery in different breast cancer subtypes in the Swedish Breast Cancer Group 91 radiotherapy randomized clinical trial

Purpose: To evaluate the effect of adjuvant radiotherapy (RT) after breast conservation surgery in different breast cancer subtypes in a large, randomized clinical trial with long-term follow-up. Patients and Methods: Tumor tissue was collected from 1,003 patients with node-negative, stage I and II breast cancer who were randomly assigned in the Swedish Breast Cancer Group 91 Radiotherapy trial be

Ion Migration Heals Trapping Centers in CH3NH3PbBr3 Perovskite

We investigate the local changes in photophysics at different microregions of a methylammonium lead bromide (MAPbBr3) perovskite crystal under illumination. Our results show that the emission from the structurally homogeneous region is blue-shifted compared to the emission from the inhomogeneous regions. The yield and spectrum of the emission from the structurally homogeneous region do not vary wi

Measurement of quarkonium production in proton–lead and proton–proton collisions at 5.02TeV with the ATLAS detector

The modification of the production of J/ ψ, ψ(2 S) , and Υ(nS) (n= 1 , 2 , 3) in p+Pb collisions with respect to their production in pp collisions has been studied. The p+Pb and pp datasets used in this paper correspond to integrated luminosities of 28nb-1 and 25pb-1 respectively, collected in 2013 and 2015 by the ATLAS detector at the LHC, both at a centre-of-mass energy per nucleon pair of 5.02

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Despite widely acknowledged problems of aggression, presumptions on its constructive and destructive possibilities, its role in psychic health and development, aggression still remains scarcely explored phenomenon. In-depth gender sensitive understanding of aggression might not just broaden our scientific scope, but might also become a vehicle for social as well as personal change. The aim of this

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Anger, its development, differentiation, expression and control are important themes in psychotherapy process. Psychotherapists have developed different hypotheses about anger dynamics and have related it to effectiveness of psychotherapy. The study explores a subjective experience of long-term psychotherapy process. Seven women with experience in analytical, psychodynamic or existential therapy p

Business Model Experimentation for Circularity: Driving sustainability in a large international clothing retailer

Business model experimentation for sustainability is an intentional and systematic approach to identify, test and learn about value creation strategies that could be adopted by a business in response to current unsustainable trajectories. For businesses such as large clothing retailers the need to alter course is acute as pressure builds from economic, environmental and social angles. The circular