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Carcinogen-DNA adducts result from the covalent interaction of electrophilic chemical carcinogens with nucleophilic sites in DNA. Some highly reactive genotoxic carcinogens are capable of directly binding to DNA but most carcinogens require metabolic activation. DNA adducts, if not repaired, can lead to mutations, and mutations in critical genes are a characteristic feature of tumors. Thus DNA add
The Swedish system has features both of civil law and of common law. Thus precedents play a more important role than they do in a dear-cut civil law or code system. Sweden has courts of first instance, six courts of appeal and a Supreme Court. Since Sweden is not a federal state, it ha.s - apart from administrative courts and the like - only one court organization. We shall discuss mainly the prac
The recent development of ultrafast extreme ultraviolet (XUV) coherent light sources bears great potential for a better understanding of the structure and dynamics of matter. Promising routes are advanced coherent control and nonlinear spectroscopy schemes in the XUV energy range, yielding unprecedented spatial and temporal resolution. However, their implementation has been hampered by the experim
Hypothesis: Previous works have shown that many-body interactions induced by dispersants with increasing correlation length will generate a diminishing two-phase region [Soft Matter 14, 6921 (2018)]. We conjecture that the attenuation of the depletion attraction due to many-body interactions is a ubiquitous phenomenon in medium-induced interactions. We propose mixtures of colloidal particles and r
This study assesses the effect of some extended Enterprise Resource Planning (ERP) capabilities (Collaboration, Analytics, Web-portals, Add-ons) and ERP use on ERP value. The research conducted, followed a mixed-methods approach using an exploratory study (Delphi) and the resource-based view of the firm to understand the ERP capabilities and develop three competing models surrounding these capabil
Background: Growing evidence suggests that pesticide exposure may influence respiratory health, but data in young children are very limited. We examined the association of prenatal pesticide exposure with lower respiratory tract infections (LRTIs) and wheeze at one year of age in children from the Infants' Environmental Health (ISA) study in Costa Rica. Methods: We measured seven pesticide metabol
Aims: Infectious complications frequently occur in intensive care unit patients admitted after out-of-hospital cardiac arrest. There is debate on the effects of temperature management on the incidence of infections, as well as on the efficacy and choice of antibiotic prophylaxis. In this substudy of the targeted temperature management (TTM) trial, we describe the microbiological profile of infecti
Observations during the Ice in Clouds Experiment-Tropical (ICE-T) field experiment show that the ice particles concentration in a developing deep convective clouds at the level of T = −15 °C reached about 500 L−1, that is, many orders higher than that of ice-nucleating particle. To simulate microphysics of these clouds, the 2-D Hebrew University Cloud model (HUCM) with spectral bin microphysics wa
Background: The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism. However the limited clinical evidence for the role of neurogenic inflammation in asthma or chronic obstructive pulmonary disease raises an alternative possibil
Background Atopic dermatitis (AD) is caused by a complex interplay between immune and barrier abnormalities. Murine models of AD are essential for preclinical assessments of new treatments. Although many models have been used to simulate AD, their transcriptomic profiles are not fully understood, and a comparison of these models with the human AD transcriptomic fingerprint is lacking. Objective We
From its inception, leadership studies has embraced the positivist tradition of hypothesis testing. In this tradition, psychometric instruments are meant to ward off belief from scientific practice by testing theories against empirical facts. While leadership scholars purport to conform to the standards of value-neutral science, this paper tells a different story. Drawing on qualitative interviews
The boreal biome exchanges large amounts of carbon (C) and greenhouse gases (GHGs) with the atmosphere and thus significantly affects the global climate. A managed boreal landscape consists of various sinks and sources of carbon dioxide (CO2), methane (CH4), and dissolved organic and inorganic carbon (DOC and DIC) across forests, mires, lakes, and streams. Due to the spatial heterogeneity, large u
Event-based sampling has been proposed as a general technique for lowering the average communication rate, energy consumption and computational burden in remote state estimation. However, the design of the event trigger is critical for good performance. In this paper, we study the combination of innovation-based triggering and state estimation of nonlinear dynamical systems using the particle filt
Oxidative stress is one of the earliest events in the pathogenesis of Alzheimer's disease (AD) and can markedly exacerbate amyloid pathology. Modulation of antioxidant and anti-inflammatory pathways represents an important approach for AD therapy. Synthetic triterpenoids have been found to facilitate antioxidant response and reduce inflammation in several models. We investigated the effect of the
Introduction: Dystonia-deafness syndrome is a distinct clinical presentation within the dystonia-spectrum. Although several genetic and acquired causes have been reported, etiology remains unknown in the majority of patients. Objectives: To describe two patients with dystonia-deafness syndrome due to a beta-actin gene mutation. Methods: We report on disease course, genetic testing, and management
This thesis work concerns the further developments of dual-broadband rotational coherent anti-Stokes Raman spectroscopy (RCARS) through experimental and theoretical investigations. Rotational CARS is an established technique for gas-phase thermometry and concentration measurement with major applications in combustion diagnostics. The technique has previously mainly been applied on species with lin
This dissertation deals with finite-size effects in a few different quantum many-body phenomena in ultracold atomic systems. The finite-sized systems were simulated numerically using both mean-field methods and methods beyond mean-field, e.g. quadratic configuration interaction and exact diagonalization. The thesis is based on five scientific papers:Paper I is about the finite-size effects in the
