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Geographical and sociodemographic differences in discontinuation of medication for chronic obstructive pulmonary disease – a cross-classified multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA)
Background: While discontinuation of COPD maintenance medication is a known problem, the proportion of patients with discontinuation and its geographical and sociodemographic distribution are so far unknown in Sweden. Therefore, we analyse this question by applying an innovative approach called multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA). Patients and Metho
Seeing the nomads like a state : Sweden and the sámi at the turn of the last century
In modern history, states have typically attempted to eliminate nomadism. Perhaps uniquely, Sweden reinforced nomadism among some of its Sámi population. In this chapter, I argue that the reason for this was twofold. First, reindeer herding necessitated nomadism, and it was thought to be the only economic contribution parts of the traditional Sámi land could provide. Second, a discourse of Boreali
Introduction
The End of History was the title of Francis Fukuyama’s book (Fukuyama 1992), suggesting that with the demise of communism in the Soviet Union and Eastern Europe after the Berlin Wall, the consequence was that The Market had come out victorious after the Cold War, and now there was only one way ahead, and the savior capitalism would relentlessly lead to democracy. Now we know that this is not the c
Social democracy and the fate of the swedish model
Sweden attracted much attention as an interesting socioeconomic role model already in the 1930s, especially after Marquis Childs published his famous and influential book, The Swedish Middle Way (1936). Childs’ main argument was that the “Swedish model” was a successful “socialist” policy with a growing cooperative sector-as a counterbalance to the private sector-and effective crisis management. O
Reflections on socialism in the twenty-first century : Facing market liberalism, rising inequalities and the environmental imperative
In this volume, the authors reflect on the question “what is socialism” as it pertains to today’s economy. There is particular emphasis on democratic socialism models as a potential alternative to classic authoritarian socialism. A number of topical questions are addressed such as: What is democratic socialism and is it feasible, or even viable? What can be learnt from existing democratic socialis
A Nationwide Cohort Study of Outcome after Pediatric Appendicitis
Introduction Children with appendicitis often present with complicated disease. The aim of this study was to describe the clinical management of pediatric appendicitis, and to report how disease severity and operative modality are associated with short- and long-term risks of adverse outcome. Materials and Methods A nationwide retrospective cohort study of all Swedish children (
Developing a mobile activity game for stroke survivors—lessons learned
Persons who have survived a stroke might lower the risk of having recurrent strokes by adopting a healthier lifestyle with more exercise. One way to promote exercising is by fitness or exergame apps for mobile phones. Health and fitness apps are used by a significant portion of the consumers, but these apps are not targeted to stroke survivors, who may experience cognitive limitations (like fatigu
Expression and Purification of Intrinsically Disordered Aβ Peptide and Setup of Reproducible Aggregation Kinetics Experiment
High purity and sequence homogeneity of intrinsically disordered proteins are prerequisites for reproducible studies of the kinetics and equilibrium of their self-assembly reactions. Starting from the pure state enables quantitative studies of intrinsic and extrinsic factors in the process to understand its molecular determinants. Here we outline detailed protocols for recombinant expression and p
A dynamic mutational landscape associated with an inter-regionally diverse immune response in malignant rhabdoid tumour
Malignant rhabdoid tumour (MRT) is a childhood neoplasm of high malignancy characterised by biallelic mutation and/or loss of the epigenetic master regulator SMARCB1, accompanied by no or few other oncogenic drivers. In spite of their generally low mutational burden, an intratumoural T-cell response has been reported in a subset of MRTs, indicating that immune checkpoint inhibition may be consider
Solvability and complex limit bicharacteristics
We shall study the solvability of pseudodifferential operators which are not of principal type. The operator will have complex principal symbol satisfying condition (Ψ) and we shall consider the limits of semibicharacteristics at the set where the principal symbol vanishes of at least second order. The convergence shall be as smooth curves, and we shall assume that the normalized complex Hamilton
Hypoxic-Ischemic Encephalopathy Evaluated by Brain Autopsy and Neuroprognostication after Cardiac Arrest
Importance: Neuroprognostication studies are potentially susceptible to a self-fulfilling prophecy as investigated prognostic parameters may affect withdrawal of life-sustaining therapy. Objective: To compare the results of prognostic parameters after cardiac arrest (CA) with the histopathologically determined severity of hypoxic-ischemic encephalopathy (HIE) obtained from autopsy results. Design,
Impact of beam angle choice on pencil beam scanning breath-hold protontherapy for lung lesions
Introduction:The breath-hold technique inter alia has been suggested to mitigate the detrimental effect of motion on pencil beam scanned (PBS) proton therapy dose distributions. The aim of this study was to evaluate the robustness of incident proton beam angles to day-to-day anatomical variations in breath-hold.Materials and methods: Single field PBS plans at five degrees increments in the transve
Visual outcome, endocrine function and tumor control after fractionated stereotactic radiation therapy of craniopharyngiomas in adults : findings in a prospective cohort
Background: The purpose of this study was to examine visual outcome, endocrine function and tumor control in a prospective cohort of craniopharyngioma patients, treated with fractionated stereotactic radiation therapy (FSRT). Material and methods: Sixteen adult patients with craniopharyngiomas were eligible for analysis. They were treated with linear accelerator-based FSRT during 1999–2015. In all
Patterns of failure for patients with glioblastoma following O-(2-[18F]fluoroethyl)-L-tyrosine PET- and MRI-guided radiotherapy
Background and purpose To evaluate the patterns of failure following clinical introduction of amino-acid O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-PET-guided target definition for radiotherapy (RT) of glioblastoma patients. Materials and methods The first 66 consecutive patients with confirmed histology, scanned using FET-PET/CT and MRI were selected for evaluation. Chemo-radiotherapy was delivered
Liquid fiducial marker applicability in proton therapy of locally advanced lung cancer
Background and purpose We investigated the clinical applicability of a novel liquid fiducial marker (LFM) for image-guided pencil beam scanned (PBS) proton therapy (PBSPT) of locally advanced lung cancer (LALC). Materials and methods The relative proton stopping power (RSP) of the LFM was calculated and measured. Dose perturbations of the LFM and three solid markers, in a phantom, were measured. P
Prognostic value of 18F-FET PET imaging in re-irradiation of high-grade glioma : Results of a phase I clinical trial
Background and purpose Positron emission tomography (PET) provides quantitative metabolic information and potential biomarkers of treatment outcome. We aimed to determine the prognostic value of early 18F-fluoroethyl-tyrosine (18F-FET) PET scans acquired during re-irradiation for recurrent high-grade glioma (HGG). Material and methods A phase I clinical trial of re-irradiation of HGG was carried o
Prospective assessment of the quality of life before, during and after image guided intensity modulated radiotherapy for prostate cancer
Background: Radiotherapy (RT) in combination with androgen deprivation therapy (ADT) for prostate cancer (PCa) carries a risk of gastrointestinal (GI) and genitourinary toxicity, which might affect the quality of life (QoL). The purpose of this study was to assess the QoL in patients with PCa before, during and after radiotherapy (RT) and to compare the QoL 1 year after RT to a normal population.
Robustness of the Voluntary Breath-Hold Approach for the Treatment of Peripheral Lung Tumors Using Hypofractionated Pencil Beam Scanning Proton Therapy
Purpose The safe clinical implementation of pencil beam scanning (PBS) proton therapy for lung tumors is complicated by the delivery uncertainties caused by breathing motion. The purpose of this feasibility study was to investigate whether a voluntary breath-hold technique could limit the delivery uncertainties resulting from interfractional motion. Methods and Materials Data from 15 patients with
A generative model for segmentation of tumor and organs-at-risk for radiation therapy planning of glioblastoma patients
We present a fully automated generative method for simultaneous brain tumor and organs-at-risk segmentation in multi-modal magnetic resonance images. The method combines an existing whole-brain segmentation technique with a spatial tumor prior, which uses convolutional restricted Boltzmann machines to model tumor shape. The method is not tuned to any specific imaging protocol and can simultaneousl