Laminin α2 chain-deficient muscular dystrophy, or LAMA2-CMD, is a very severe disease caused by mutations in the LAMA2 gene. Skeletal muscle is the most affected tissue, with patients presenting symptoms such as hypotonia at birth, joint contractures and progressive muscle wasting. Changes in the central nervous system include white matter abnormalities, delayed motor milestones and compromised ac

Energy intensive industries (EIIs), producing the basic materials and products needed in society, contribute significantly to global emissions of greenhouse gases (GHGs). Motivated by the fear of carbon leakage, climate policy has so far treated the EIIs leniently with e.g. low carbon prices and/or free allocation of emission allowances. This has not resulted in more than marginal emission abatemeEnergy intensive industries (EIIs), producing the basic materials and products needed in society, contributesignificantly to global emissions of greenhouse gases (GHGs). Motivated by the fear of carbon leakage, climatepolicy has so far treated the EIIs leniently with e.g. low carbon prices and/or free allocation of emissionallowances. This has not resulted in more than marginal emission abatement.

We introduce a memory model for robots that can account for many aspects of an inner world, ranging from object permanence, episodic memory, and planning to imagination and reveries. It is modeled after neurophysiological data and includes parts of the cerebral cortex together with models of arousal systems that are relevant for consciousness. The three central components are an identification net

The need to decrease emissions from the transport sector is getting urgent and public transport can play an important role in the transition to low emission fuels. To a large extent, public transport in Europe is provided by regional authorities who controls the traffic to a varying degree, from complete public monopoly to competitive tendering. Therefore, the aim of this paper is to analyse how t

Pain and depressive symptoms are common reasons for adolescents to contact the school nurse. The aim was to describe the prevalence of pain (headache, abdominal pain, and back pain) and depressive symptoms among adolescents and to examine whether there is an association between pain and depressive symptoms. This cross-sectional survey included students (N = 639) in Sweden (median age: 16 years). O

A series of 3-triazole-thiogalactosides and 3,3′-triazole-thiodigalactosides substituted with different five-membered heterocycles at the C-4 triazole position were found to have high selectivity for galectin-1. Initial studies on the 3-triazole-thiogalactosides indicated that five membered heterocycles in general gave increased affinity for galectin-1 and improved selectivity over galectin-3. The

Living labs for sustainability, low carbon and smart cities that have emerged in Europe have different goals and ways of working, they are initiated by various actors, and they form different types of partnerships. There is clearly no uniform definition of living labs. Some scholars and organisations define them as partnerships between sectors (often between public, private and people) where unive

Industrial processes currently account for a significant share (25–35 %) of the world’s total energy demand and related emis- sions. During recent years, the amount of low-carbon electric- ity from renewable energy sources (such as wind and solar) has increased continuously. There is therefore an increasing inter- est in electrification of industrial processes in order to achieve long-term decarboIndustrial processes currently account for a signifcant share (25–35 %) of the world’s total energy demand and related emissions. During recent years, the amount of low-carbon electricity from renewable energy sources (such as wind and solar) has increased continuously. Tere is therefore an increasing interestin electrifcation of industrial processes in order to achieve long-term decarbonisation g

The Scandinavian heart transplant everolimus de novo study with early calcineurin inhibitors avoidance (SCHEDULE) trial was a 12 month, randomized, open-label, parallel-group trial that compared everolimus (EVR; n=56) to conventional CsA (n=59) immunosuppression. Previously, we reported that EVR outperformed CsA in improving renal function and coronary artery vasculopathy, despite a higher rejecti

Presently, there is no single, coherent theory on the causality between cities and economic growth, only a fragmented set of theories. Current patterns and trends for the relationship between cities and economic growth, however, suggest that a full understanding of contemporary processes will not be achieved by relying on the tools of one discipline alone, or by focusing on a single level of analyPresently, there is no single, coherent theory on the causality between cities and economic growth, only a fragmented set of theories. Current patterns and trends for the relationship between cities and economic growth, however, suggest that a full understanding of contemporary processes will not be achieved by relying on the tools of one discipline alone, or by focusing on a single level of analy

Why are female children still at risk in India despite progress in education, increasing participation of women in economic and political activities, and an overall improvement in the status of women? Is there any significant shift from 'son preference' to 'daughter discrimination'? Based on a study of two villages from low-fertility regions of Karnataka and Tamil Nadu, this paper attempts to unde

The importance of school climate in schooling has been demonstrated consistently over the last 50 years. In this study, we investigate how individual student norms and opinions shape and affect school climate. Through the use of secondary survey data collected within two research projects at eight schools throughout Sweden in two different years, we demonstrate how individual student norms develop

In this paper, we present a study for the identification of authors’ national variety of English in texts from social media. In data from Facebook and Twitter, information about the author’s social profile is annotated, and the national English variety (US, UK, AUS, CAN, NNS) that each author uses is attributed. We tested four feature types: formal linguistic features, POS features, lexicon-based