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The role of water coordination in the pH-dependent gating of hAQP10

Human aquaporin 10 (hAQP10) is an aquaglyceroporin that assists in maintaining glycerol flux in adipocytes during lipolysis at low pH. Hence, a molecular understanding of the pH-sensitive glycerol conductance may open up for drug development in obesity and metabolically related disorders. Control of hAQP10-mediated glycerol flux has been linked to the cytoplasmic end of the channel, where a unique

Is road-side fishpond water in Bangladesh safe for human use? An assessment using water quality indices

Pond water is used in everyday life by many people in Bangladesh, however, without sufficient and reliable information regarding water quality and pollution status. For this reason, geospatial analysis and mapping of water quality indices such as metal (MI), contamination (Cd), and physicochemical water quality index (WQI) were assessed to improve the understanding of potential pollution sources.

1H detection and dynamic nuclear polarization–enhanced NMR of Aβ1-42 fibrils

Several publications describing high-resolution structures of amyloid-β (Aβ) and other fibrils have demonstrated that magic-angle spinning (MAS) NMR spectroscopy is an ideal tool for studying amyloids at atomic resolution. Nonetheless, MAS NMR suffers from low sensitivity, requiring relatively large amounts of samples and extensive signal acquisition periods, which in turn limits the questions tha

Long term oncologic and reproductive outcomes after robot-assisted radical trachelectomy for early-stage cervical cancer. An international multicenter study

Objectives: Long term outcomes following fertility sparing robot-assisted radical trachelectomy (RRT). Methods: A retrospective study of consecutive women selected for RRT between 2007 and 2019 at five referral centres. Generally used selection criteria for fertility-sparing surgery were applied. Oncologic, reproductive and long-term clinical data were analysed. Results: Of the 166 included women,

Difference in Performance of EPI Pigs Fed Either Lipase-Predigested or Creon®-Supplemented Semielemental Diet

Pancreatic enzyme replacement therapy (PERT) and fat predigestion are key in ensuring the optimal growth of patients with cystic fibrosis. Our study attempted to highlight differences between fat predigestion and conventional PERT on body composition of young pigs with exocrine pancreatic insufficiency (EPI). EPI and healthy pigs were fed with high-fat diet for six weeks. During the last two weeks

Is cadmium a risk factor for breast cancer - Results from a nested case-control study using data from the malmö diet and cancer study

Background: Some studies have shown that cadmium (Cd) is associated with breast cancer risk. One hypothesis is that Cd has estrogen-like properties. This case-control study investigated the association between breast cancer risk and blood Cd (BCd) levels. Methods: All breast cancers in the Malmö Diet and Cancer cohort were identified through linkage to the Swedish Cancer Registry, baseline (1991-1

Att lämna sitt trossamfund : Några sociologiska perspektiv

I boken görs en analys av intervjuer med personer som lämnat ett trossamfund utan att gå med i ett annat. De intervjuades livsberättelser presenteras och belyses utifrån aktuell religionssociologisk och samhällsvetenskaplig teoribildning.

Prevalence of Facial Pain and Headache in Sweden

Aims: To compare the prevalence of facial pain and headache across various regions in Sweden. Methods: This study involved a comparison of cross-sectional questionnaire studies over a period of 10 years including 128,193 individuals and assessed facial pain, pain on function, and headache. Participants included (1) all Public Dental Service patients aged 16 to 90 years in Västerbotten (n = 57,283)

Prenatal Gyrification Pattern Affects Age at Onset in Frontotemporal Dementia

The paracingulate sulcus is a tertiary sulcus formed during the third trimester. In healthy individuals paracingulate sulcation is more prevalent in the left hemisphere. The anterior cingulate and paracingulate gyri are focal points of neurodegeneration in behavioral variant frontotemporal dementia (bvFTD). This study aims to determine the prevalence and impact of paracingulate sulcation in bvFTD.

Release of carbon nanotubes during combustion of polymer nanocomposites in a pilot-scale facility for waste incineration

Nanocomposites, formed by incorporating nanoparticles into a matrix of standard materials, are increasing on the market. Little focus has been directed towards safe disposal and recycling of these new materials even though the disposal has been identified as a phase of the products' life cycle with a high risk of uncontrolled emissions of nanomaterials. In this study, we investigate if the carbon

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Similarly to many OECD countries, repair has been replaced by purchasing of alternatives which has accrelated production and accompanying environmental impacts. With the re-recognition of the necessity of closure of material loops repair has been receiving renewed policy attention, both at the EU and Swedish level. There are also initiatives such as repair cafe that seek to equip citizens with too

Gudmuntorps romanska kyrka och spåren av en västgötsk separatist? : En vandring med Rikard Holmberg och strövtåg på egen hand

Genom fyndet av delar från en eller två Husabykistor, med en klar anknytning till Väster­götlands medeltida härskargrupp, under gräset på Gudmuntorps kyrkogård aktualiserades en genomgång av Rikard Holmbergs undersökning av den medeltida kyrkan samt de slutsatser han presenterat i en artikel för snart 60 år sedan. Resultatet blir att en kyrka med kunglig prakt och möjligen en oppositionell grupper

En introduktion- i väntan på tåget

Den första bransch som kände industrialiseringens verkningar var lantbruket. I Kävlinge trakten förändrades lantbruket på många sätt genom industrialiseringens innovationer, långt innan järnvägen kom och industrierna etablerades.