OBJECTIVE: To investigate whether genetic susceptibility to type 1 diabetes or maturity-onset diabetes of the young (MODY) increases susceptibility to gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: We studied mutations in MODY1-4 genes, the presence of GAD antibodies, and HLA DQB1 risk genotypes in 66 Swedish women with GDM and a family history of diabetes. An oral glucose toler

Evidence has accumulated that apoptotic cell death contributes to brain damage following experimental seizures. A substantial number of degenerating neurons within limbic regions display morphological features of apoptosis following prolonged seizures evoked by systemic or local injections of kainic acid, systemic injections of pilocarpine and sustained stimulation of the perforant path. Although

Abstract in UndeterminedPlans for the European Proteomics Association (EuPA) were conceived and established during 2004 and 2005, and culminated in the formal inception of the Organisation during the 4th HUPO World Congress held in Munich in 2005. The mission from the outset has been three-tiered and is to: i) strengthen the national Proteomics organizations in their efforts; ii) to co-ordinate an

OBJECTIVE: Leukocytes mediate hepatocellular injury in obstructive cholestasis. The aim of the present study was to define the role of P-selectin glycoprotein ligand-1 (PSGL-1) in cholestasis-induced leukocyte recruitment and liver damage. METHODS: C57BL/6 mice were pre-treated with an anti-PSGL-1 antibody or a control antibody prior to bile duct ligation (BDL) for 12 h. Hepatic recruitment of leu

In the article a simulation model of pricing behaviour on the gasoline market in Sweden is reported. First a brief review of price-changes during a historical period is provided. Next the model is presented in three steps with increasing level of detail for each step. The companies in the model are assumed to have three goals but only one variable for action

Abstract is not available

We present a unified approach for calculating the properties of shallow donors inside or outside heterostructure quantum wells. The method allows us to obtain not only the binding energies of all localized states of any symmetry, but also the energy width of the resonant states which may appear when a localized state becomes degenerate with the continuous quantum well subbands. The approach is non

Today most patients with CF reach adulthood and consequently marry and have children. Health care systems are lacking in knowledge of how these adults cope with the strain of having children. Eight patients were interviewed about their experiences of having children. The study was a qualitative descriptive study and the patients were interviewed with open questions regarding their experiences of p

We investigated the role of the major histocompatibility complex (MHC) region in the specificity of autoimmunity by analysing specifically the development of sialadenitis, but also insulitis, nephritis and autoantibody production in autoimmune-prone nonobese diabetic (NOD) mice where the MHC H2g7 haplotype had been exchanged for the H2q (NOD.Q) or H2p (NOD.P) haplotype. The exchange of H2 haplotyp

Intervju med Paul Verhoeven

Hydrophobic interaction chromatography (HIC) and other capture media are typically produced by grafting different ligands to base matrices at defined surface densities. This often complicates media production. An alternative approach to media involving in situ radical initiated polymerization was used to graft polymer coatings directly at Sepharose(D polymeric base matrices. This method appears su

Feminists, like many others, want to make a difference. They are interested in social change. They are especially interested in the ways this concerns the position of women in our societies. In order to accomplish this, the different actors within the women’s movements of Europe must be present in the political arenas where decisions are made. This concerns white indigenous women, as well as Black

Lifetimes of states in the yrast superdeformed bands of Lu-163 and Lu-164 were determined in a Doppler-shift attenuation-method experiment. From fractional Doppler shifts and line shapes, average transition quadrupole moments, Q(t) = 8.2(-0.6)(+1.0) b and 7.1(-0.6)(+0.5) 1), were deduced for one of the bands in Lu-163 OX -0.6 and Lu-164, respectively. These values are much larger than the quadrupo

We present a statistical analysis of proton resonances in the compound nucleus Tc-93 in terms of random matrix theory (RMT). The fluctuation properties of energy levels and reduced widths from data measured by Bilpuch et al. [Phys. Rev. C 9 (1974) 1589] are studied. We conclude that one T> = 9/2 isobaric analog state does not affect the spectral correlations of a sequence of 124 T< = 7/2 states, a

Background No data exist regarding mortality rate in young patients with a first-time anterior shoulder dislocation. A cohort of 255 patients aged 1240 years had a primary anterior shoulder dislocation during the years 1978 and 1979. After 10 years, 9 of the patients had died-which is a high figure for this cohort of patients. The question thus arose as to whether these patients had an increased m