A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited relatives of the identified carriers and showed that protection was associated with better insulin secretion due to enhanced glucose responsiveness and proinsulin conversion, particularly when compared with individual

The aim of this study was to explore patients’ experiences of using the Integrated Palliative care Outcome Scale (IPOS) during specialized palliative home care. The study adopted a qualitative approach with an interpretive descriptive design. Interviews were performed with 10 patients, of whom a majority were diagnosed with incurable cancer. Our findings suggest that the use of IPOS as a basis for

There is a scarcity of information on mineral and phytate content in plant-based foods in Bolivia. This study aimed to analyze iron, zinc, calcium, and phytate content and estimate the mineral bioavailability of foods consumed in Chapare, Bolivia. Minerals and phytate were analyzed, and bioavailability was estimated in 17 food samples. Leafy vegetables and green legumes had the highest mineral con

Introduction: Lower limb revascularization with inguinal incisions is a common vascular surgical procedure. Due to risk of injury to lymphatic vessels and a diverse bacterial flora in the groin, surgical site infections (SSI) represent a common and sometimes life-threatening complication. While transverse incisions in endovascular aneurysm repair has a low SSI rate, vertical incisions in thrombend

In recent decades, obesity has gone from being a problem of first world countries to a global one. It is considered one of the main risk factors for many serious medical conditions. In order to treat and/or prevent obesity different strategies have been considered, one of the most common being the inhibition of lipase, the enzyme that is mainly responsible for lipid digestion. Even though there is

Objective: To examine cause-specific mortality beyond cardiovascular diseases (CVDs) in patients with gout compared to the general population. Methods: We included all residents of Skåne (Sweden) age ≥18 years in the year 2002. Using the Skåne Healthcare Register, we identified subjects with a new diagnosis of gout (2003–2013) and matched each person with gout with 10 comparators free of gout, by

During periods of predation risk, prey adopt antipredator behaviours to maximise chances of survival, such as increased vigilance, reduced foraging time, shifting to safe habitat, and group formation. To effectively balance resource acquisition and antipredator behavior, prey animals make use of cues within their environment that provide them accurate information about the realistic threat of pred

Purpose: To investigate incidence and location of locoregional recurrence (LRR) in patients who have received postoperative locoregional radiation therapy (LRRT) for primary breast cancer. LRR-position in relation to applied radiotherapy and the primary tumor biological subtype were analyzed with the aim of evaluating current target guidelines and radiation therapy techniques in relation to tumor

Knowledge bases are largely developed and utilized in academic and industrial fields, such as DBPedia, VIAF, LoC, Getty, and which are published in the Linked Data format. However, if you want to view different resources on these knowledge bases, you have to switch between different web pages from these resources. Therefore, we proposed a decentralized data hub named SinoPedia, which consists of s

Purpose: The purpose of this paper is to explain the “evaluation deadlock” or “stasis” diagnosed by many authors. The explanation relies on a thought experiment. Design/methodology/approach: The paper is conceptual and builds on a thought experiment inspired by qualitative research such as interviews with communication consultants in Sweden. It makes use of principal–agent theory and Akerlof’s the

Lack of water resources is a common issue in many countries, especially in the Middle East. Flood spreading project (FSP) is an artificial recharge technique, which is generally suggested for arid and semi-arid areas with two major aims including (1) flood mitigation and (2) artificial recharge of groundwater. This study implemented three state-of-the-art popular models including frequency ratio (

Gender assignment in languages with a gender system is a complex issue, as this can be influenced by both semantic, morphological, and phonological factors (Corbett, 1991, 2013; Corbett & Fraser, 2000). Many Indo-European languages possess a three-gender system, which distinguishes masculine, feminine, and neuter gender. Whereas this system is preserved in several Indo-European branches, it ha

Migration can influence host–parasite dynamics in animals by increasing exposure to parasites, by reducing the energy available for immune defense, or by culling of infected individuals. These mechanisms have been demonstrated in several comparative analyses; however, few studies have investigated whether conspecific variation in migration distance may also be related to infection risk. Here, we a

The application of the Chao-Raimondi emittance adapter to the SOLEIL storage ring is studied theoretically in terms of linear and nonlinear beam dynamics. This unique scheme recently proposed elsewhere using a pair of emittance adapters and a solenoid in between them allows a local conversion of an electron beam in a third generation light source to an ultralow emittance beam of the fourth generat

Inspired by the recently-reported strong electric-dipole (E1) transition between the weakly-bound first and second excited states, 3/2- at 765 keV and 1/2+ at 885 keV, in the nucleus Ne171027, the E1 transition is estimated in a model by properly taking into account the effect of both deformation and weakly-bound neutrons. In addition to both the spin-parities, 1/2+ and 3/2-, and observed nearly d

A free port for art is a location in a country with purpose-built art facilities where imported works of art may be stored without taxes such as value added tax (VAT), goods and services tax (GST), consumption tax, transaction taxes and customs duties. As long as the art does not leave the free port, such taxes are not imposed, hence the word “free”. These free ports could be regarded as special t