The receptor tyrosine kinase FLT3 is expressed almost exclusively in the hematopoietic compartment. Binding of its ligand, FLT3 ligand (FL), induces dimerization and activation of its intrinsic tyrosine kinase activity. This leads to autophosphorylation of FLT3 on several tyrosine residues which constitute high affinity binding sites for signal transduction molecules. Recruitment of these signal t

1.INTRODUCTIONBefore the phase-out of incandescent lamps in the EU, interior lighting was responsible for approximately 20% of average household electricity use in Sweden. To save energy and reduce greenhouse gas emissions, a major societal goal is to switch from light sources with low lm/W to ones with higher luminous efficacy and to reduce wasteful energy behaviour, while still meeting end user

The elegant cyclist: Cycling, fashion and femininity in Swedish and Danish women’s magazines at the turn of the 20th century.At the turn of the 20th century the new sport of cycling was endowed with femininity in Scandinavian ladies’ magazines. An analysis of the magazines Idun, Svensk Damtidning, Damernes Blad and Hjemmet between 1890 and the 1910s show that both Swedish and Danish magazines appe

Different presynaptic neuromodulation systems have been explored as possible targets to manage neurodegenerative diseases. However, most studies used young adult animals whereas neurodegenerative diseases are prevalent in the elderly. Thus, we now explored by Western blot analysis how the density of different presynaptic markers and receptors changes with aging in rat hippocampal synaptosomes (pur

The aim of the study was to identify changes in agricultural practices and periods of agricultural expansion and regression during the last 1,300 years in the South-Swedish Uplands. Sediments from the small lake of Skärpingsgölen (1.2 ha) were used to quantify land-cover at a local scale (c. 1 km radius) in 50-year intervals based on pollen analysis and the LOVE model (Local Vegetation Estimates).

The aim of this study was to clarify how positive and negative emotions are related to the common attitude-change effect in cognitive dissonance research. Drawing on appraisal theories of emotion, and emotion-regulation research, we predicted that negative emotions would be inversely related to attitude change, whereas positive emotions would be positively related to attitude change in the inducedThe aim of this study was to clarify how positive and negative emotions are related to the common attitude-change effect in cognitive dissonance research. Drawing on appraisal theories of emotion, and emotion-regulation research, we predicted that negative emotions would be inversely related to attitude change, whereas positive emotions would be positively related to attitude change in the induced

Alzheimer's disease (AD) is characterized by pathological aggregation of β-amyloid peptides and MAP-Tau protein. β-Amyloid (Aβ) is a peptide responsible for extracellular Alzheimer's plaque formation. Intracellular MAP-Tau aggregates appear as a result of hyperphosphorylation of this cytoskeletal protein. Small, oligomeric forms of Aβ are intermediate products that appear before the amyloid plaque

Dendrimers are branched polymeric structures that have been shown to have a promising antiamyloidogenic potential by interfering with the polymerization process leading to the formation of the amyloid aggregates related to conformational diseases, such as Alzheimer's and prion diseases. It has been established that there is a relationship between the morphology of the amyloid aggregates and the am

Aims/hypothesis: Growth differentiation factor 15 (GDF-15) is an anti-inflammatory cytokine of the transforming growth factor-β superfamily. Circulating levels of GDF-15 are associated with hyperglycaemia among people with obesity or diabetes, but longitudinal evidence on the association between GDF-15 levels and diabetes risk is scarce. Our aim was to explore whether circulating levels of GDF-15

Efter det fredliga regimskiftet under april 2018 var alla parter överens om att man behövde hålla tidiga val för att bättre återge den rådande allmänna opinionen i landet. Den 9 december höll man extra val som blev historiska i landets moderna historia, både i utförande men också utgång. Denna artikel ger bakgrund och en kort analys av valet och dess innebörd.

Research was conducted to examine the transient performance of a final settler. Dynamical models of minimal order were derived based on effluent data collected from a pilot scale settler. Parameter values for the models were adjusted until satisfactory fits to the observed data were obtained. Results were compared to select those models with the simplest structures and the ability to predict the m

A recursive algorithm for parametric identification of discrete-time systems known as Panuska's method, the approximate maximum likelihood method or the extended matrix method, is analyzed. Making use of recently developed theory for asymptotic analysis of recursive stochastic algorithms, dynamic systems, and autoregressive moving average (ARMA) processes are constructed for which this algorithm d

The trajectories of politically activist and socially committed interpretations of Islam in (late)modern societies continue to spur heated debate and academic discussion. A recurrent theme is the compatibility of Islamic ideological/legal foundations vis-à-vis secular state institutions and liberal democracy. Other debates concern rights and identity politics, problematizing the recognition of relThe trajectories of politically activist and socially committed interpretations of Islam in (late)modern societies continue to spur heated debate and academic discussion. A recurrent theme is the compatibility of Islamic ideological/legal foundations vis-à-vis secular state institutions and liberal democracy. Other debates concern rights and identity politics, problematizing the recognition of rel

In 18 untreated adult patients (median age 62.5 yr) with advanced non‐Hodgkin's lymphoma of unfavourable histology, thymidine labelling indices (LIs) of the lymphoma cells were assessed. The patients were treated with combination chemotherapy and have been followed for 29–60 (median 52) months or until death. The survival curve had a steep fall during the first 2 yr. Between 2–5 yr after treatment