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Background: High-grade glioma (HGG) of the spinal cord constitutes rare tumors in the pediatric population. Knowledge of the molecular profile of this pediatric HGG (pedHGG) subgroup is limited and the clinical outcome is poor. Therefore, the aim of this study is to provide more profound investigations of molecular characteristics and clinical features of these tumors. Methods: Between January 201

Background: The application of international recommendations for paediatric maintenance haemodialysis (HD) could be strengthened by national laws or written recommendations. Our aim was therefore to describe the national rules governing paediatric maintenance HD in European countries. Methods: A national representative, approved by the president of each paediatric nephrology society, was contacted

Predictors for the pharmacological effect of ADHD medication in children and adolescents are lacking. This study examined clinically relevant factors in a large (N = 638) prospective cohort reflecting real-world evidence. Children and adolescents aged 6–17 diagnosed with ADHD were evaluated at baseline and three months following ADHD medication initiation. The outcome was measured as a reduction i

Among different lipid nanoparticle systems, sponge-phase nanoparticles (SPNPs) have recently attracted interest due to their ability to encapsulate large macromolecules along with demonstrated high interfacial activity. The potential application of SPNPs calls for investigations into how buffer conditions affect SPNP structure and interfacial activity. Herein, we systematically investigated how di

Interpretation of data from faint dwarf galaxies is made challenging by observations limited to only the brightest stars. We present a major improvement to tackle this challenge by undertaking zoomed cosmological simulations that resolve the evolution of all individual stars more massive than 0.5 M⊙, thereby explicitly tracking all observable stars for the Hubble time. For the first time, we predi

Background: Community-acquired pneumonia (CAP) was one of the most common causes of death in the European Union in 2017. Severity and mortality of CAP increase with age and an aging European population will require increased planning for prevention, control, and management of CAP. The purpose of this study was to provide an updated population-based estimate of the incidence of CAP requiring hospit

Background: Adverse pregnancy outcomes, such as preterm delivery and hypertensive disorders of pregnancy, may be associated with higher future risks of heart failure (HF). However, the comparative effects of different adverse pregnancy outcomes on long-term risk of HF, and their potential causality, are unclear. OBJECTIVES: The authors sought to examine 5 major adverse pregnancy outcomes in relati

Background Obsessive-compulsive disorder (OCD) is associated with an increased risk of morbidity and mortality due to cardiometabolic disorders. Whether this association is driven by familial factors is unknown. This population-based family study explored the familial co-aggregation of OCD and cardiometabolic disorders. Methods We identified 6 049 717 individuals born in Sweden between 1950 and 20

Background: The aging of the world’s population and the increase in sedentary lifestyles are leading to an increase in walking impairments at older ages. Here, we aimed to comprehensively discuss walking in the context of an aging population; and identify and agree on a list of future research priorities and policy actions. Methods: We followed a participatory approach and held a multidisciplinary

Policy institutes such as central banks need accurate forecasts of key measures of economic activity to design stabilization policies that reduce the severity of economic fluctuations. Therefore, this paper develops a kernel ridge regression estimator in a mixed data sampling framework. Kernel ridge regression can handle many predictors with a nonlinear relationship to the target variable. Consequ

A novel mechanism of sequestering tumor suppressor mRNAs reveals new therapeutic vulnerabilities in leukemic cells.

In dialogical self theory (DST) authenticity has not been a central concern. The humanist notion of a static, higher-order, superordinate, ultimate, and “true” self runs counter to the ontology of DST, and the conceptualization of the dialogical self as unconsolidated, multifaceted, dynamic, and sensitive to situational change. In a climate in which the psychology of authenticity is undergoing rev

We investigate experimentally the quantum coherence of an electronic two-level system in a double quantum dot under continuous charge detection. The charge state of the two-level system is monitored by a capacitively coupled single quantum dot detector that imposes a backaction effect on the system. The measured backaction is well described by an additional decoherence rate, approximately linearly

Vid gravområdet Ormknös på Björkö hittades under 1970-talet en drejad kanna med hank i en av gravarna. Den kan nu bestämmas till en produktion inom khazariskt område vid Azovska sjön. En abbasidisk dirhem funnen i graven anger en nedläggning till 800-talets mitt eller strax därefter. Kannan av tamatarchatyp är ovanlig utanför produktionsområdet. Den anknyter till de östfärder som utgör ett tidigt

BACKGROUND: Proteases are important enzymes in food and pharmaceutical industries, but challenges persist in their recombinant production due to host cell proteome hydrolysis and fitness loss. The development of recombinant expression systems for directed evolution of proteolytic enzymes, and industrial production are desirable. This study evaluated Saccharomyces cerevisiae as expression host for

Airborne depth sounding lidar has proven to be a valuable sensor for rapid and accurate sounding of shallow areas. The received lidar pulse echo contains information of the sea floor depth, but also other data can be extracted. We currently perform work on bottom classification and water turbidity estimation based on lidar data. In this paper we present the theoretical background and experimental

Över tid har stora förskjutningar mellan olika kategorier av nyhetsmaterial ägt rum i en lokaltidning som Ystads Allehanda.I den här artikeln ligger fokus på utrikesnyheternas minskade och det lokala materialets ökade betydelse.Förskjutningen mellan dessa båda kategorier exemplifieras med en jämförelse mellan åren 1939 och 2025.