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The complement system plays a pivotal protective role in the innate immune response to many pathogens including flaviviruses. Flavivirus nonstructural protein 1 (NS1) is a secreted nonstructural glycoprotein that accumulates in plasma to high levels and is displayed on the surface of infected cells but absent from viral particles. Previous work has defined an immune evasion role of flavivirus NS1

Pt-TiO2-C composites with different titanium oxide loading were synthesized by photo-deposition and chemical vapor deposition methods. The changes in their electronic properties improve the electrochemical activity toward the oxygen reduction reaction (ORR) compared to the Pt-C catalyst synthesized at the same conditions. The platinum samples were physically characterized by means of Transmission

This thesis aimed to investigate possibilities to utilize death certificates in cancer epidemiology by analyzing nationwide databases from Sweden. Excessive information is available when investigating causes of death in cancer patients, including comorbidities and metastatic patterns. We used the Swedish Family- Cancer Database, which includes data from e.g. the Cause of Death Register and the Can

We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs

Skeletal muscle is a dynamic tissue with a remarkable ability to continuously respond to environmental stimuli. Among its adaptive responses is the widely investigated ability of skeletal muscle to regenerate after loading or injury or both. Although significant basic science efforts have been dedicated to better understand the underlying mechanism controlling skeletal muscle regeneration, there h

The collective wobbling mode, the strongest signature for the rotation of a triaxial nucleus, has previously been seen only in a few Lu isotopes in spite of extensive searches in nearby isotopes. A sequence of transitions in the N = 94 Ta-167 nucleus exhibiting features similar to those attributed to the wobbling bands in the Lu nuclei has now been found. This band feeds into the pi i(13/2) band a

The proportion of hand injuries in Swedish children is the second highest in relation to other parts of the body. The incidence of hand injuries in these children has not yet been estimated. In addition, aetiologies, injury patterns and costs among Swedish children have not been presented on a regional or national level. Also, very few studies have focused on hand injuries within specific ages for

Recent studies on young men from the general population have demonstrated geographic and ethnic differences in semen quality. The aim of this study was to investigate whether reported ethnic differences in semen quality might be associated with the maternally derived CAG and GGN polymorphisms in the androgen receptor gene or paternal ethnicity. In total 114 military conscripts from Latvia were inc

Popular Abstract in Swedish Biologiska organismer har en fantastisk förmåga att anpassa sig till alla möjliga miljöer. Människans aktiviteter på jorden har skapat många nya habitat för olika typer av organismer; t ex kan vissa organismer växa på sten och vertikala klippor och när människor bygger hus så kan dessa organismer flytta över till väggar och tak som blir nya biotoper att leva på. Några aBiological organisms have an incredible ability to adapt to almost any environment and the humans activities on earth have created many new habitats for different kinds of organisms. For example can certain organisms grow on rocks and vertical cliffs, and when humans started building houses with mineral based façades, some organisms found that these were new habitats to live on. Some of these expa

A measurement of event shape variables is presented for large momentum transfer proton-proton collisions using the ATLAS detector at the Large Hadron Collider. Six event shape variables calculated using hadronic jets are studied in inclusive multi-jet events in 35 pb(-1) of integrated luminosity at a center-of-mass energy of root s = 7 TeV. These measurements are compared to predictions by three M

Selection on proteins is typically measured with the assumption that each protein acts independently. However, selection more likely acts at higher levels of biological organization, requiring an integrative view of protein function. Here, we built a kinetic model for de novo pyrimidine biosynthesis in the yeast Saccharomyces cerevisiae to relate pathway function to selective pressures on individu

BACKGROUND AND OBJECTIVES: Transfusion of blood products in particular older products is associated with patient morbidity. Previously, we demonstrated a higher incidence of acute lung injury in lipopolysaccharide-treated sheep transfused with stored blood products. As transfusion following haemorrhage is more common, we aimed to determine whether a 'first hit' of isolated haemorrhage would prec

The basis for this thesis is mainly gathered from Lund University’s Archives of Ecclesiastical History, LUKA. Questionnaires called ”kyrklig sed” are frequently emitted to all Swedish parishes to document different customs within the church. Since 1962 they also contain questions about cribs in the churches. Beside these questionnaires, there are also special questionnaires of different extent. LU

A rotating, two-component Bose-Einstein condensate is shown to exhibit vortices of multiple quantization, which are possible due to the interatomic interactions between the two species. Also, persistent currents are absent in this system. Finally, the order parameter has a very simple structure for a range of angular momenta.

Embryonic development is associated with extensive rearrangements of tissues. The driving force for these rearrangements is generated by a dynamic reorganization of the Actin cytoskeleton of individual cells. In many instances, conserved Rho-family GTPases that are activated by Rho guanine nucleotide exchange factors (RhoGEFs) play an important role in this process. The present thesis investigates

Emerging concepts for on-chip biotechnologies aim to replace microfluidic flow by active, molecular-motor driven transport of cytoskeletal filaments, including applications in bio-simulation, biocomputation, diagnostics, and drug screening. Many of these applications require reliable detection, with minimal data acquisition, of filaments at many, local checkpoints in a device consisting of a poten