Purpose of review To discuss the rationale for various treatment strategies in rheumatoid arthritis with extra-articular manifestations, and to review advances in understanding the impact of extra-articular rheumatoid arthritis and its management. Recent findings Recent epidemiologic studies of extra-articular rheumatoid arthritis manifestations have emphasized their major role as predictors of pr

Background: A veld fire disaster in the Tlokwe Local Municipality on 23 August 2011, resultedin an estimated monetary loss of over R43 million. The veld fire disaster was characterised by a lack of strategic management and a subsequent lack of planned, coordinated communication between all role players involved. The lack of strategic communication management indirectly contributed to the losses su

The proinflammatory mediator leukotriene D(4) (LTD(4)) binds to the seven-transmembrane receptor CYSLT(1). Although this leukotriene plays an important biological role, its intracellular signaling pathways are only partly known. In previous experiments, we found that LTD(4) induced tyrosine phosphorylation and translocation of phospholipase (PLC)-gamma1 to a plasma membrane fraction in a human epi

Orglet er et af de musikinstrumenter, som stadig anvendes i dag, der er at finde længst tilbage i den vesteuropæiske musiktradition. Allerede i det 3. århundrede f.Kr. findes versioner af instrumentet hos grækerne, som med tiden blev så populære, at de blev et fast element under de romerske gladiatorkampe. I middelalderen flyttede orglet ind i kristne kirkerum, først som flytbare orgler og siden 1

In laser-wakefield acceleration (LWFA), a femtosecond laser pulse is tightly focused in a gas to intensities exceeding 1018 W/cm2 . The laser radiation ionizes the medium and excites a plasma wave that travels behind the laser pulse. Electrons can be trapped in the oscillations in the plasma density, where electric fields of the order of several hundreds of GV/m accelerate them to relativistic ene

Objective. The aim of this study was to examine the occurrence of repair in a cohort of conventionally treated patients with early rheumatoid arthritis over 8 years.Methods. There were 395 patients included in the BARFOT study having radiographs of hands and feet at inclusion, and at 1, 2, 5, and 8 years, which were chronologically scored for erosions by the Sharp/van der Heijde method. An erosion

Patients with alkaptonuria lack homogentisate 1,2-dioxygenase leading to retention of homogentistic acid (HGA) in body fluids and eventually to tissue deposition of oxidation products, giving rise to the clinical picture of ochronosis. Ascorbic acid is a known inhibitor of the enzyme which catalyses the oxidation of homogentisic acid (HGA) to the polymer with affinity for collagen and was used in

For high-resolution massive MIMO and very large antenna arrays, wireless channel models have to scrutinize the detailed space features of the surrounding environment. Existing models such as WINNER and 3GPP are not appropriate for validating and evaluating new concepts for 4G/5G as they do not consider the spatial characteristics of the real environment. The simplified 3D shapes of simulated objec

Föreliggande rapport beskriver forskningsarbetet inom projektet: ”Utveckling av MMC för högpresterande aluminiumkomponenter – Vinnova 2015–05072 som leds av Marie Fredriksson vid Swerea SWECAST i Jönköping. Redovisade resultat bygger också på tidigare kunskaper och tidigare projekt som forskargruppen vid Lunds universitet genomfört. Resultaten från detta arbete visar att det kan vara fullt möjligt

Background.In some regions, including the Baltic Sea, fatty fish such as salmon and herring contain high levels of polychlorinated dibenzodioxins and dibenzofurans. We investigated human exposure to these potentially toxic substances in relation to the consumption of fish from the Baltic Sea.Methods.Plasma levels of 10 different dibenzofurans and 7 dioxins were analyzed in three groups of Swedish

Swedish Central Bank Policy in the Post-War Period: Some CommentsThis article discusses the nature of the actions taken by the Swedish central bank - the Riksbank - in the post-war period and examines some of the consequences of these measures. In this context the views of the critics of the Riksbank are presented. Further, a review of the Riksbank’s measures is given. A distinction between moneta