Frontotemporal dementia (FTD)-causing mutations in the CHMP2B gene lead to the generation of mutant C-terminally truncated CHMP2B. We report that transgenic mice expressing endogenous levels of mutant CHMP2B developed late-onset brain volume loss associated with frank neuronal loss and FTD-like changes in social behaviour. These data are the first to show neurodegeneration in mice expressing mutan

Lignin is the second most abundant naturally produced organic polymer on earth. Lignin‐modifying enzymes (LMEs) are produced by the white‐rot fungi as products of secondary metabolism, since lignin degradation does not provide any energy to the fungus. The main oxidative enzymes include the peroxidases‐lignin peroxidase (LiP) (diarylpropane: oxygen, hydrogen peroxide oxidoreductase), manganese per

An academic journal is a special place – even more so an online journal. On the one hand, it is surely one of the main stages of professional qualification, presentation and academic discourse, though regulated through its gatekeeping structures of peer review, official invitation, of academic critique and corrections: it represents an open and accessible, yet not unregulated public space in the b

Surgical patients are at high risk of developing postoperative cognitive dysfunction (POCD) and postoperative delirium (POD). POCD and POD are associated with increased morbidity and mortality and worsening functional outcomes leading to severe socioeconomic consequences for the patient and the society in general. Magnetic resonance imaging (MRI) offers a unique opportunity to study the anatomy an

OBJECTIVES:The aim of this study was to apply a previously published method for evaluating radiographic progression, namely, predicted vs. observed radiographic progression in early rheumatoid arthritis (POPeRA), to the Swedish pharmacotherapy (SWEFOT) trial.METHOD:In SWEFOT, 487 patients with eRA were given methotrexate (MTX), and non-responders were randomized to group A [triple therapy: MTX+sul

Twenty-one of 25 consecutive primary fibromyalgia or fibrositis patients, identified during a 5-year period in a tertiary care day-ward for pain syndromes, were re-examined. Fifteen fulfilled criteria for fibromyalgia but unexpectedly, all cases had either psychiatric disturbance or thyroid dysfunction. Of the four patients not seen at follow-up, two had developed neurological diseases, another rh

In this paper we investigate the typical behaviour of minimum distance and ML word error probability of a serial turbo concatenation with random interleaver, when the interleaver length N goes to infinity. Our main result shows that the word error probability P(e) goes to zero subexponentially in N with probability one. While it is known that 10glE[P(e)]/logN converges to a constant, we prove that

We extend Burnashev's [5] classic result for the error exponent of discrete memoryless channels with feedback to the case of Markov channels with ISI and feedback. This is a nontrivial extension of our previous work [6] where we treated the case of Markov channels with feedback but without ISI. Tools from stochastic control theory are used to treat the case with ISI.

Vietnam is one of the countries most vulnerable to climate change impacts, especially from extreme weather events such as storms and floods. Thus, climate change adaptation is crucial, especially for natural resource-dependent farmers. Based on a qualitative research approach using a feminist political ecology lens, this article investigates gendered patterns of rural agrarian livelihoods and clim