In order to investigate the molecular mechanisms by which the oncogenic mutant KIT/D816V causes transformation of cells, we investigated proteins that selectively bind KIT/D816V, but not wild-type KIT, as potential mediators of transformation. By mass spectrometry several proteins were identified, among them a previously uncharacterized protein denoted XKR5 (XK-related protein 5), which is related

Purpose: A traffic safety analysis that is based on registered crashes often suffers from underreporting, which may result in biased conclusions and lead to misguided crash-prevention strategies. Self-reporting traffic crashes is a complementary method to obtain crash information that is often not available in official databases. By surveying studies from around the world, this paper aims to map t

I argue that Paul Ricœur displaces and decentres established theodicies; the issue of evil is perceived as a practical rather than a speculative matter. It is the view of evil as a productive aporia, which suggests that evil provokes action and obliges human beings to take a stand ethically and politically. Hence, the topic of evil is not necessarily about putting together a jigsaw puzzle. The cen

This chapter starts with the question of how damages for violation through crime are determined by law. Compensation for criminal injuries is the predominant type of non-pecuniary damages in Swedish tort law. Yet, a fundamental uncertainty exists regarding computation of damages and the legal meaning of ‘violation’. The general consensus in the legal profession is that norms for computation of damThis chapter starts with the question of how damages for violation through crime are determined by law. Compensation for criminal injuries is the predominant type of nonpecuniary damages in Swedish tort law. Yet, a fundamental uncertainty exists regarding computation of damages and the legal meaning of ‘violation’. The general consensus in the legal profession is that norms for computation of dama

Syftet med studien är att undersöka det förbättrade upptaget av det radioaktiva spåret Technetium-99m-DTPA (99mTc-DTPA) i råtta Muskelvävnad i Fischer 344 råttor efter applicerade elektriska pulser med olika fältstyrka och pulslängd,Metoder: 99mTc-DTPA (totalt 150 MBq) administrerades intramuskulärt (i.m.) vid axeln som en bolus i flera fraktioner av 50 l vardera i intervaller på 1 minut. Bilder

Three-dimensional (3D) solar maps based on Radiance simulations are presented for a future city district in southern Norway. The surface mapping method provides the commercial developer with a practical tool to evaluate the potential for building integrated photovoltaics (BIPV). The solar maps identify the optimum roof and facade areas available for solar energy utilization. The importance of BIPV

The pT-differential production cross section of prompt Λc + charmed baryons was measured with the ALICE detector at the Large Hadron Collider (LHC) in pp collisions at s=7 TeV and in p-Pb collisions at sNN=5.02 TeV at midrapidity. The Λc + and Λ¯ c ¯ were reconstructed in the hadronic decay modes Λc + → pK−π+, Λc + → pKS 0 and in the semileptonic channel Λc + → e+νeΛ (and charge conjugates). The m

The light-dependent magnetic compass of birds provides orientation information about the spatial alignment of the geomagnetic field. It is proposed to be located in the avian retina, and be mediated by a light-induced, biochemical radical-pair mechanism involving cryptochromes as putative receptor molecules. At the same time, cryptochromes are known for their role in the negative feedback loop in

Background: The United States (US) is currently facing a public health crisis due to the percentage of obesity in adolescents. The Center for Disease Control (CDC) stated the risks for children due to obesity are many. Adolescents obtain a large portion of their daily caloric intake at school; therefore, what foods/drinks they are consuming is so serious. Objective: To identify and analyze literat

Cerebral amyloid angiopathy (CAA) results from amyloid accumulation within arteries of the cerebral cortex and leptomeninges. This condition is age-related, especially prevalent in Alzheimer’s disease (AD), and the main feature of certain hereditary disorders (i.e., HCHWA-I). The vascular smooth muscle cells (VSMCs) appear to play a vital role in the development of CAA, which makes them well suite

Interdisciplinary research in the fields of forestry and sustainability studies often encounters seemingly incompatible ontological assumptions deriving from natural and social sciences. The perceived incompatibilities might emerge from the epistemological and ontological claims of the theories or models directly employed in the interdisciplinary collaboration; or they might be created by other epInterdisciplinary research in the fields of forestry and sustainability studies often encounters seemingly incompatible ontological assumptions deriving from natural and social sciences. The perceived incompatibilities might emerge from the epistemological and ontological claims of the theories or models directly employed in the interdisciplinary collaboration, or they might be created by other ep

Filmrecension.

Background: According to the literature the three stone diseases, sialolithiasis (SL), urolithiasis (UL) and cholelithiasis (CL) share comorbidities. We assess familial and spouse risks between these stone disease and compare them to familial risks for concordant (same) stone disease. Methods: Study population including familiar relationships was obtained from the Swedish Multigeneration Register

B-lymphocyte differentiation is one of the best understood developmental pathways in the hematopoietic system. Our understanding of the developmental trajectories linking the multipotent hematopoietic stem cell to the mature functional B-lymphocyte is extensive as a result of efforts to identify and prospectively isolate progenitors at defined maturation stages. The identification of defined proge