Context Inpatients with nonvalvular atrial fibrillation, warfarin prevents ischemic stroke, but dose adjustment, coagulation monitoring, and bleeding limit its use. Objective To compare the efficacy of the oral direct thrombin inhibitor ximelagatran with warfarin for prevention of stroke and systemic embolism. Design, Setting, and Participants Double-blind, randomized, multicenter trial (20002001)

Cartilage oligomeric matrix protein (COMP) is a pentameric glycoprotein present in cartilage, tendon and ligament. Fragments of the molecule are present in the diseased cartilage, synovial fluid and serum of patients with knee injuries, osteoarthritis and rheumatoid arthritis. Although COMP is a substrate for several matrix metalloprotemases (MMPs), the enzymes responsible for COMP degradation in

The immune system has evolved specialized cellular and molecular mechanisms for targeting and regulating immune responses at epithelial surfaces. Here we show that small intestinal intraepithelial lymphocytes and lamina propria lymphocytes migrate to thymus-expressed chemokine (TECK). This attraction is mediated by CC chemokine receptor (CCR)9, a chemoattractant receptor expressed at high levels b

Luthers kombination av Guds-ords-mystik och kallelsemedvetande blir så tydlig att den just därför varit svår att förstå. Stolt gör upp med vanföreställningar som att retorik skulle utesluta spontanitet. Hon utgår från språkvetenskapliga iakttagelser: Luthers latinska och tyska språkanvändning står i intensivt beroende av varandra, och hans nyskapande insatser för det tyska språket kan inte isolera

Hosts can in principle employ two different strategies to defend themselves against parasites: resistance and tolerance. Animals typically exhibit considerable genetic variation for resistance (the ability to limit parasite burden). However, little is known about whether animals can evolve tolerance (the ability to limit the damage caused by a given parasite burden). Using rodent malaria in labora

In order to evaluate the success of simple heuristics we need to know more about how a relevant heuristic is chosen and how we learn which cues are relevant. These meta-abilities, we believe, are at the core of ecological rationality, rather than the individual heuristics.

Twenty-one boys (age range 5 months to 16 years) were followed during their stay at hospital. Total observation time was 120 h. Field notes were made immediately after each observation. These were then transcribed into a narrative text, which was analysed by content analysis. Six categories of needs were identified during non-threatening situations at the hospital: the need for activity, the need

A dynamic beam system loaded harmonically in the axial direction and constrained in the transverse direction is modelled using different theoretical descriptions. Results from an experimental set-up are compared to calculations using Bernoulli as well as Timoshenko beam theories. Some results from investigations of this beam system unveiling its chaotic nature have earlier been presented, but here

Different strategies for reducing emissions of nitrogen oxides and carbon dioxide from the Swedish transportation sector are evaluated by making scenarios for the year 2015, using a bottom-up approach. Methods for reducing emissions of carbon monoxide, hydrocarbons, and sulphur dioxide are discussed more briefly. The scenarios are based on official forecasts of future passenger and goods transport

Abstract in Danish Afhandlingens hovedproblemstillinger er: Hvilken betydning har det for danske socialarbejderes vurderinger og handlinger i børnefamiliearbejdet, at et barn og dets familie ikke er etniske danskere? Denne problemstilling undersøges gennem tre empiriske undersøgelser: Familieplejeundersøgelsen består af en journalundersøgelse af 44 anbragte etniske minoritetsbørns journaler samt The dissertation studies how social workers ensure continuity in relation to the individual child's background when placing and working with children of ethnic minority background in care. This is studied through 44 sets of case study notes from a foster-care association and interviews with 10 foster-care consultants. These two types of data are analysed through three perspectives: a continuity pe

This working paper on Tongan names for plants and animals is intended as a contribution to the documentation of environmental knowledge in one of the most traditional societies of Polynesia. The list contains over 1 400 folk taxa: seaweeds 18 names, terrestrial plants 801 names, marine invertebrates 203 names, terrestrial invertebrates 72 names, fishes 231 names, reptiles and amphibians 15 names,