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α1-microglobulin (A1M) is a 26 kDa plasma and tissue protein with reductase activity and radical- and heme-binding anti-oxidative functions. In addition, exposure of A1M to hemoglobin has been shown to induce proteolytic elimination of a C-terminal tetrapeptide yielding a heme-degrading form, truncated A1M (t-A1M). Myeloperoxidase (MPO), a heme-containing enzyme that catalyzes the production of fr

Popular Abstract in Swedish Den vanligaste barncancerformen är akut leukemi, en form av blodcancer som uppstår i immunförsvarets celler och som drabbar cirka 75 barn i Sverige varje år. Även om de flesta av barnen idag botas får en av fem återfall och då minskar överlevnaden drastiskt trots intensiv behandling. Vad det är som gör leukemin mer motståndskraftig när den återkommer vet man ännu inte iAcute lymphoblastic leukemia (ALL) is characterized by an accumulation of immature lymphoid cells in the bone marrow and is the most common cancer type in children. It is an immunophenotypically, morphologically, clinically, and genetically heterogeneous disorder that comprises several distinct subtypes. Proper classification is important because determining the correct subtype plays a vital role

BACKGROUND AND PURPOSE: Computed tomography (CT) is used to study coronary artery plaques, but little is known about its potential to characterize plaque composition. This study assesses the relation between carotid calcium score (CCS) by CT and plaque composition, namely extracellular matrix, inflammatory mediators, and calcium metabolites. METHODS: Thirty patients with significant carotid sten

It has been suggested that speakers with an L1 with lexical tones may have an advantage when it comes to perceptually discriminating between different tones in another tone language (Kaan, Wayland, Bao & Barkley, 2007). Other studies in L2-learning show that this is not entirely the case (van Dommelen & Husby 2009, So & Best 2010). A model of typological pitch prominence (Schaefer &

Abstract in UndeterminedThe objective of the report is to analyse simulation results coming from the use of a policy evaluation method that encompasses a wider set of determinants for technology choice. To that end, we use the EEB_Sweden model v1.0. Still in an early stage of development, the model offers an opportunity to capture or integrate critical modelling aspects that justify our research p

Equilibrium fluctuation analysis of single binding events has been used to extract binding kinetics of ligand interactions with cell-membrane bound receptors. Time-dependent total internal reflection fluorescence (TIRF) imaging was used to extract residence-time statistics of fluorescently stained liposomes derived directly from cell membranes upon their binding to surface-immobilized antibody fra

In the Nordic countries machine strength grading of structural timber is becoming increasingly important. A new standard, EN 14081, which allows CE-marking of strength graded structural timber was recently accepted. This standard allows both machine

control and output control as methods for controlling the graded timber. Machine control is most commonly used in Europe. The project reporte

Background: Exercise facilities may have the potential to promote physical activity among residents, and to support an active lifestyle throughout the year. We investigated the association between objectively assessed availability of exercise facilities and objectively assessed physical activity outcomes, and whether time of year had a modifying effect on these associations. Methods: A total of 2,

To increase the accuracy of molecular force fields a systematical and balanced improvement of the various terms included is needed. In this work, we have followed this strategy to improve the quality of the NEMO potential for the formaldehyde dimer by introducing local quadrupole moments and higher-order polarizabilities. It is found that inclusion of the quadrupole moment significantly improves t

Alzheimer's Disease (AD) is the most prevalent form of dementia worldwide, yet the development of therapeutics has been hampered by the absence of suitable biomarkers to diagnose the disease in its early stages prior to the formation of amyloid plaques and the occurrence of irreversible neuronal damage. Since oligomeric A beta species have been implicated in the pathophysiology of AD, we reasoned

Background: In adults, impaired myocardial repolarization and increased risk of arrhythmia are known consequences of open heart surgery. Little is known, however, about post-operative consequences of cardiopulmonary bypass surgery in children. The aim of this study was to assess ventricular repolarization and coronary perfusion after bypass surgery for atrial septal defect (ASD) repair in children

The value of family history as a risk factor for kidney failure has not been determined in a nationwide setting.

The flavocytochrome cellobiose dehydrogenase (CDH) is secreted by wood-decomposing fungi, and is the only known extracellular enzyme with the characteristics of an electron transfer protein. Its proposed function is reduction of lytic polysaccharide mono-oxygenase for subsequent cellulose depolymerization. Electrons are transferred from FADH(2) in the catalytic flavodehydrogenase domain of CDH to

Background: The metabolism of amyloid precursor protein (APP) and beta-amyloid (A beta) is widely studied in Alzheimer's disease, where A beta deposition and plaque development are essential components of the pathogenesis. However, the physiological role of amyloid in the adult nervous system remains largely unknown. We have previously found altered cerebral amyloid metabolism in other neuroinflam

The cost efficiency of the biorefining process can be improved by extracting high-molecular-mass hemicelluloses from lignocellulosic biomass prior to ethanol production. These hemicelluloses can be used in several high-value-added applications and are likely to be important raw materials in the future. In this study, steam pretreatment in an alkaline environment was used to pretreat the lignocellu

Study objectives: The aim of this study was to develop quality criteria for further development and use in the Medicines Management(MM) process in European hospitals. Methods: Criteria for MM were developed in three steps using a modified two-stage Delphi-technique. In the first step a literature search was performed and 300 topics were listed. These topics were grouped into three dimensions, e

Background. Giant cell tumor of bone (GCTB) is an aggressive primary osteolytic tumor. GCTB often involves the epiphysis, usually causing substantial pain and functional disability. Denosumab, a fully human monoclonal antibody against receptor activator of nuclear factor. kappa beta ligand (RANKL), is an effective treatment option for patients with advanced GCTB. This analysis of data from an ongo

Det finns en ganska stor samstämmighet bland forskare och också bland många planerare att en rad åtgärder behövs för att transportsystemet skall kunna anpassas till miljömålen. I den här studien har vi undersökt hur olika bebyggelseparametrar påverkar resandet och energianvändningen. Flertalet studier inom området har fokuserat på stora städer. I vår studie har vi analyserat orter i Skåne. Syftet