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The SAGA so far : Reading the history of the Galaxy with asteroseismology
Asteroseismology has the capability of delivering stellar properties which would otherwise be inaccessible, such as radii, masses and thus ages of stars. When this information is coupled with classical determinations of stellar parameters, such as metallicities, effective temperatures and angular diameters, powerful new diagnostics for stellar and Galactic studies can be obtained. The ongoing Strö
What makes scholarly works "interesting" in entrepreneurship research? : Learning from the past
Comparison of the Lift-Off Lengths Obtained by Simultaneous OH-LIF and OH∗ Chemiluminescence Imaging in an Optical Heavy-Duty Diesel Engine
The presence of OH radicals as a marker of the high temperature reaction region usually has been used to determine the lift-off length (LOL) in diesel engines. Both OH Laser Induced Fluorescence (LIF) and OH∗ chemiluminescence diagnostics have been widely used in optical engines for measuring the LOL. OH∗ chemiluminescence is radiation from OH being formed in the exited states (OH∗). As a conseque
High-Speed Particle Image Velocimetry Measurement of Partially Premixed Combustion (PPC) in a Light Duty Engine for Different Injection Strategies
It has been proven that partially premixed combustion (PPC) has the capability of high combustion efficiency with low soot and NOx emissions, which meet the requirements of increasingly restricted emission regulations. In order to obtain more homogenous combustion and longer ignition delay in PPC, different fuel injection strategies were employed which could affect the fuel air mixing and control
Automated Multi-Objective Control for Self-Adaptive Software Design
While software is becoming more complex everyday, the requirements on its behavior are not getting any easier to satisfy. An application should offer a certain quality of service, adapt to the current environmental conditions and withstand runtime variations that were simply unpredictable during the design phase. To tackle this complexity, control theory has been proposed as a technique for managi
Involvement of End Users in a Navigation Aid Design Project
This paper describes the involvement of end users in a project aimed to create a navigation aid for older persons who have memory decline, which affects navigation skills, and thus their independence. Interviews, focus groups with “stick man scenarios” and shorter usability tests seemed to work well. An extended test where the users themselves were expected to use the system independently was not
The role of communication professionals in the digital age - old paradoxes, new distinctions?
Social intranets and internal communication : Dreaming of democracy in organisations
Perception of Highlight Disparity at a Distance in Consumer Head-Mounted Displays
Stereo rendering for 3D displays and for virtual reality headsets provide several visual cues, including convergence angle and high- light disparity. The human visual system interprets these cues to estimate surface properties of the displayed environment. Naïve stereo rendering effectively doubles the computational burden of image synthesis, and thus it is desirable to reuse as many computa- tion
Global leadership - sustaining classic managerialism
This chapter critically discusses the currently celebrated and seemingly successful trend of global leadership. We claim that part of the answer to why global leadership has become so successful lies in how it is framed and presented as an all-embracing and intuitively good discourse closely aligned with the traditional leader-centred view on leadership in general. While this makes the discourse o
Migratory common blackbirds have lower innate immune function during autumn migration than resident conspecifics
Animals need awell-functioning immune systemto protect themselves againstpathogens. The immune system, however, is costlyand resource trade-offs withother demands exist. For migratory animals several (not mutually exclusive)hypotheses exist. First, migrants reduce immune function to be able to allocateresources to migration. Second, migrants boost immune function to cope withmore and/or novel path
Physiological role of TNF in mucosal immunology : Regulation of macrophage/dendritic cell function
Intestinal mononuclear phagocytes, comprising macrophages (MΦs) and dendritic cells (DCs), play important roles in the generation and the regulation of immune responses to intestinal antigens, and alterations in the development and/or the function of these cells are thought to contribute to the pathogenesis of inflammatory bowel disease. In this review, we discuss the role of tumor necrosis factor
Exploring the roles of university spin-offs in business networks
This paper identifies different university spin-off (USO) roles related to resource interaction among business parties. It does so by mapping how USOs become part of business networks in terms of their roles relative to other parties. The theoretical frame of reference focuses on roles and resource interaction based on an industrial network approach to business markets. The empirical research is b
The spleen dictates platelet destruction, anti-platelet antibody production, and lymphocyte distribution patterns in a murine model of immune thrombocytopenia
For many years, splenectomy has been used to treat immune thrombocytopenia (ITP), and this procedure benefits approximately two-thirds of the treated patients. Although splenectomy may raise platelet counts, antibody-coated platelets and cytotoxic T lymphocytes appear to persist or can change over time. To better understand how the spleen may affect anti-platelet immune responses, we used a murine
The nonhemostatic immune functions of platelets
Platelets are megakaryocyte-derived cellular fragments, which lack a nucleus and are the smallest circulating cells and are classically known to have a major role in supporting hemostasis. Apart from this well-established role, it is now becoming evident that platelets are also capable of conveying other important functions, such as during infection and inflammation. This paper will outline these
Move over Tregs, MDSCs are here
In this issue of Blood, Hou et al show the involvement of myeloid-derived suppressor cells (MDSCs) in the pathogenesis of immune thrombocytopenia (ITP) and identify a novel mechanism by which high-dose dexamethasone (HD-DXM) promotes MDSC expansion and function and correlates with increased platelet counts.
Microparticles as biomarkers of lung disease : enumeration in biological fluids using lipid bilayer microspheres
Extracellular vesicles, specifically microparticles (MPs), are rapidly gaining attention for their capacity to act as biomarkers for diagnosis, prognosis, or responsiveness to therapy in lung disease, in keeping with the concept of precision medicine. However, MP analysis by high-sensitivity flow cytometry (FCM) is complicated by a lack of accurate means for MP enumeration. To address this gap, we
CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder with a complex pathogenesis, which includes both antibody- and T-cell-mediated effector mechanisms. Rituximab (an anti-human CD20 monoclonal antibody [mAb]) is one of the treatments for ITP and is known to deplete B cells but may also work by affecting the T-cell compartments. Here, we investigated the outcome of B-cell depletion (Bd
Acute Lung Injury Causes Asynchronous Alveolar Ventilation That Can Be Corrected by Individual Sighs
RATIONALE: Improved ventilation strategies have been the mainstay for reducing mortality in acute respiratory distress syndrome. Their unique clinical effectiveness is, however, unmatched by our understanding of the underlying mechanobiology, and their impact on alveolar dynamics and gas exchange remains largely speculative.OBJECTIVES: To assess changes in alveolar dynamics and associated effects