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Strategies for cessation of caffeine administration in preterm infants

Background: Apnea and intermittent hypoxemia (IH) are common developmental disorders in infants born earlier than 37 weeks' gestation. Caffeine administration has been shown to lower the incidence of these disorders in preterm infants. Cessation of caffeine treatment is based on different post-menstrual ages (PMA) and resolution of symptoms. There is uncertainty about the best timing for caffeine

Towards automated inclusion of autoxidation chemistry in models : from precursors to atmospheric implications

In the last few decades, atmospheric formation of secondary organic aerosols (SOA) has gained increasing attention due to their impact on air quality and climate. However, methods to predict their abundance are mainly empirical and may fail under real atmospheric conditions. In this work, a close-to-mechanistic approach allowing SOA quantification is presented, with a focus on a chain-like chemica

Pregnancy Planning and Genetic Testing: Exploring Advantages, and Challenges

Pregnancy planning and genetic testing (PPGT) has emerged as a tool in reproductive healthcare, offering parents-to-be insight in their risks of having a child with a genetic disorder. This paper reviews the advantages, drawbacks and challenges associated with PPGT, providing some practical guidance for health care professionals. Advantages include identification of genetic risks, a possibility to

Mortality Rate by Diagnosis in ANCA-Associated Vasculitis Across FAIRVASC Registries

Background/ Objectives: Research into ANCA-associated vasculitis (AAV) is hampered by the rarity of the disease and thesubsequent small sample sizes of observational cohorts. This is further aggravated by the observational cohorts being containedin fragmented data pools and lacking standardisation to allow for interoperability. FAIRVASC is a Europe-wide research project,which has developed an infr

Drug exposure and subsequent diagnosis with ANCA-associated vasculitis – A population-based case- control study

Objective: To determine if prior exposure to certain drugs is associated with increased risk of ANCA associated vasculitis(AAV).Patients and Method: We performed a population-based case–control study including patients with AAV diagnosed between2006 and 2019 from a defined geographic area in southern Sweden. For each case, we identified 10 controls randomly sampledfrom the background general popul

Temporal clustering of ANCA-associated vasculitis occurrence

Background: We hypothesised that observed annual incidence rates of ANCA-associated vasculitis (AAV) are driven bysporadic short-term, high-intensity rates characterised as clusters of diagnosis events in time. Using data from Ireland, Swedenand Spain, we performed a changepoint analysis to discover time intervals with high and low rates of vasculitis diagnosis.Methods: We recruited 417 patients f

Diatom dynamics during the last six centuries in Lake Odensjön: a new varved sediment record from southern Sweden

Varved lake sediments offer valuable insight into past environmental conditions with high temporal resolution and precise chronological control. A combination of diatom and geochemical analyses of the recently deposited sediments of Odensjön, a small dimictic lake in southern Sweden, shows alternating light and dark laminae composed of greater amounts of biogenic silica and organic matter, respect

Lake ecosystem responses to large volcanic eruptions in recent centuries: diatom and geochemical evidence from varved sediments

Volcanic eruptions are documented throughout geological history and are frequently observed and experienced in the modernworld. Strong eruptions in recent decades have resulted in air and water pollution, acid snowfall, disruption in aerial transport and variousillnesses in humans and livestock. Despite their consequences, these recent events are incomparable to eruptions of a much largermagnitude

Freedom and Moral Sentiment : Hume's Way of Naturalizing Responsibility

This book presents a critical examination of Hume's views on the subject of freedom and moral responsibility. It is widely held that Hume's discussions “Of liberty and necessity,” as presented in both the Treatise and first Enquiry, constitute the classical statement of the “compatibilist” position – the view that freedom and moral responsibility cannot only be reconciled with causation but actual

The Riddle of Hume's Treatise : Skepticism, Naturalism, Irreligion

Although it is widely recognized that David Hume's A Treatise of Human Nature (1739‐40) belongs among the greatest works of philosophy, there is little agreement about the correct way to interpret his fundamental intentions. Among almost all commentators it is an established orthodoxy that skepticism and naturalism are the two dominant themes in this work. The difficulty has been, however, that Hu

Responsibility, Naturalism, and “The Morality System”

Even those who follow the general strategy of P. F. Strawson’s enormously influential “Freedom and Resentment” accept that his strong naturalist program needs to be substantially modified, if not rejected. An important effort to revise the Strawsonian program has been provided by R. Jay Wallace. This chapter argues that Wallace’s narrow construal of reactive attitudes, as they are involved in hold

Responsibility After ‘Morality’ : Strawson’s Naturalism and Williams’s Genealogy

Although P.F. Strawson and Bernard Williams have both made highly significant and influential contributions on the subject of moral responsibility, they never directly engaged with the views of each other. On one natural reading their views are directly opposed. Strawson seeks to discredit scepticism about moral responsibility by means of naturalistic observations and arguments. Williams, by contr