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Lack of Reactive Oxygen Species Breaks T Cell Tolerance to Collagen Type II and Allows Development of Arthritis in Mice.

The view on reactive oxygen species (ROS) in inflammation is currently shifting from being considered damaging toward having a more complex role in regulating inflammatory reactions. We recently demonstrated a role of ROS in regulation of animal models for the autoimmune disease rheumatoid arthritis. Low levels of ROS production, due to a mutation in the Ncf1 gene coding for the Ncf1 (alias p47pho

Biochemical and physiological mechanisms leading to salt tolerance

We showed that malic enzyme and F-type ATPase isolated from glycophytes and halophytes do not differ significantly in their amino acid composition. Isolated enzymes from both types of plants showed nearly identical salt sensitivity, each, but enzyme activities in fresh homogenates from halophyte leaves apparently were more salt resistant as compared to the ones from glycophytes. These results sugg

Factors influencing the compressive strength of an injectable calcium sulfate-hydroxyapatite cement.

A biphasic injectable bone substitute, suitable for filling bone defects, that sets in the body, based on calcium sulfate and hydroxyapatite (HA), is presented. For applications in bone defects the compressive strength is important to assure support of the defect site during loading when the patient is weight bearing. To control the strength, the influence of four different factors; the liquid-to-

Introduction of terminal alkynes into the 2-and 8-positions of the Troger's base core via Sonogashira reaction of 2,8-diiodo-4,10-dimethyl-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine

Conditions for the introduction of terminal alkynes into the 2- and 8-positions of the Troger's base core via Sonogashira reaction of 2,8-diiodo-4,10-dimethyl-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine were established. Only the use of the bulky and electron-rich phosphine P(t-Bu)(3) as a ligand for the palladium catalyst allowed for the Sonogashira reaction to proceed effectively. In addition,

Increased prevalence of perennial allergic rhinitis in patients with obstructive sleep apnea

Background: Impaired nasal breathing is a risk factor for obstructive sleep apnea syndrome (OSAS). Objectives: The aim of this study was to determine whether atopy to perennial allergens and existence of perennial allergic rhinitis was a risk factor for OSAS. Methods: In a case-control study, we compared the proportions of OSAS patients with atopy to perennial allergens and perennial allergic rhin

Strain in GaP/GaAs and GaAs/GaP resonant tunnelling heterostructures

We studied the morphology of GaP/(001)GaAs and GaAs/(001)GaP heterostructures grown by metal-organic vapour-phase epitaxy and found wire-like surface undulations elongated in the [110] direction. We attribute this elongation to anisotropic lateral growth rates in the [110] and [110] directions, which are due to a different roughness of monolayer surface steps. In III-V materials grown by molecular

The effect of endovascular aortic stents placed across the renal arteries

OBJECTIVES: To investigate renal artery patency and renal function after deployment of aortic stents covering the orifices of renal arteries. DESIGN: Prospective open animal study. SETTING: Department of Experimental Surgery at a university hospital. MATERIALS: Twenty-three pigs were used. METHODS: Ten pigs were observed for 1 h after graft-anchoring aortic stents, Gianturco (5) and Palmaz (5), we

Products of non-stationary random matrices and multiperiodic equations of several scaling factors

Let beta > 1 be a real number and M : R --> GL(C-d) be a uniformly almost periodic matrix-valued function. We study the asymptotic behavior of the product P-n(x) = M(beta(n-1)x)...M(betax) M(x). Under some conditions we prove a theorem of Furstenberg-Kesten type for such products of non-stationary random matrices. Theorems of Kingman and Oseledec type are also proved. The obtained results are appl

Omedelbart samarbete: En rapport om polisers handlingsutrymme vid handräckning enligt LVU och LVM

This report is about the co-operation between the police and the social services in the specific situation when the social services apply for assistance for taking children and drug-abusers in to involuntary care immediately. The police have an authority to use violence that social workers do not have. Therefore social workers need the police to accomplish this task. The report aims to reach adeep

Enhancement of Y-D(center dot) spin relaxation by the CaMn4 cluster in photosystem II detected at room temperature: A new probe for the S-cycle

The long-lived, light-induced radical Y-D(.) of the Tyr161 residue in the D2 protein of Photosystem 11 (PSII) is known to magnetically interact with the CaMn4 cluster, situated similar to 30 angstrom away. In this study we report a transient step-change increase in YD EPR intensity upon the application of a single laser flash to S, state-synchronised PSII-enriched membranes from spinach. This tran

Human endothelin subtype a receptor enhancement during tissue culture via de novo transcription

OBJECTIVE: Endothelin (ET) has, since its discovery, increasingly been considered a key player in the pathophysiological processes of cerebral vasospasm in the course of subarachnoid hemorrhage, although it remains unclear how ET is involved. We present data that indicate an inherent capacity of human cerebral arteries to change their sensitivity to ET. METHODS: Human cerebral arteries were obtain

Evaluation of surgery for acromegaly: role of intraoperative growth hormone measurement?

OBJECTIVE: Intraoperative growth hormone (GH ) measurement has earlier been tried to improve surgery for acromegaly. We calculated GH half-life after adenomectomy and evaluated the possible role of this variable in predicting the final outcome of pituitary surgery in 28 consecutive patients with acromegaly. The sensitivity, specificity and predictive values were determined in relation to the resul