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Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study

Aims Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype data to identify mechanisms of AS. Methods and results A genome-wide meta-analysis of 11.6 million variants in 10 cohorts involving 653 867 European

Farmland practices are driving bird population decline across Europe

Declines in European bird populations are reported for decades but the direct effect of major anthropogenic pressures on such declines remains unquantified. Causal relationships between pressures and bird population responses are difficult to identify as pressures interact at different spatial scales and responses vary among species. Here, we uncover direct relationships between population time-se

Collegial midwifery assistance during the active second stage of labour

AbstractSevere perineal trauma (SPT) is a serious complication following vaginal birth. To reduce its incidence rate, various preventive strategies have been implemented in Swedish obstetric units. Collegial midwifery assistance (CMA), involving an additional midwife being present during the active second stage of labour, is a clinical practice that was evaluated in the Oneplus trial, which proved

Ecological barriers mediate spatiotemporal shifts of bird communities at a continental scale

Species’ range shifts and local extinctions caused by climate change lead to community composition changes. At large spatial scales, ecological barriers, such as biome boundaries, coastlines, and elevation, can influence a community's ability to shift in response to climate change. Yet, ecological barriers are rarely considered in climate change studies, potentially hindering predictions of biodiv

From shadows to light: The role of latent networks in mainstreaming solar PV practices

Practice theories have generated interest in sustainability transitions research as a means to study shared expectations, conventions and routines that maintain unsustainable consumption within the dominant regime. However, collective action to change practices, which is crucial for innovation, is seldom examined in practice theory research. This article applies practice theories to conceptualize

Co-creating holistic injury prevention training for youth handball: Development of an intervention targeting end-users at the individual, team, and organizational levels.

BackgroundInterventions that are co-created with end-users, and that are informed by behavior change or implementation theories, support implementation in real world settings. However, injury prevention programs for youth athletes have typically been developed by experts with no, or insufficiently described, end-user involvement and without guidance by theories. The aim of the current study was to

Machine Learning Models for Prediction of Diabetic Microvascular Complications

IMPORTANCE AND AIMS: Diabetic microvascular complications significantly impact morbidity and mortality. This review focuses on machine learning/artificial intelligence (ML/AI) in predicting diabetic retinopathy (DR), diabetic kidney disease (DKD), and diabetic neuropathy (DN).METHODS: A comprehensive PubMed search from 1990 to 2023 identified studies on ML/AI models for diabetic microvascular comp

An Operatic Game-Changer : The Opera Maker as Game Designer and the Potentials of Ludo-Immersive Opera

How can live-performed chamber operas be conceptualized as immersive games with interactive features? This artistic study has resulted in a system model through which degrees of immersion may be generated and analyzed from physical, social, and psychical stimuli. A differentiation of immersive modes has been made possible by the framing of opera-making as game design. The findings indicate that so

Unfinished Business

How can microsocial rituals connected to a specific site be used as interaction templates for artistic purposes? And how can we distort such rituals artistically in order to make them memorable events? As artists, we regard distortion as the process that gives character and distinction to things and situations, as well as something that confuses and enriches information and interpretation. Through

Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients.

Introduction: Chronic pain negatively impacts a range of sensory and affective behaviors. Previous studies have shown that the presence of chronic pain not only causes hypersensitivity at the site of injury but may also be associated with pain-aversive experiences at anatomically unrelated sites. While animal studies have indicated that the cingulate and prefrontal cortices are involved in this ge

The Artificial Lyricist : Prototyping an Interactive Opera for Humans and Machines

To probe into the artistic possibilities of Artificial Intelligence (AI) generating operatic elements, we have engaged in a practice-led inquiry as designers and artists. We took the process of prototyping a chamber opera with interactive features as our starting point, exploring how AI could work as a source of stimuli in opera productions, and how prototyping might add to the design and evaluati

Why nature matters : A systematic review of intrinsic, instrumental, and relational values

In this article, we present results from a literature review of intrinsic, instrumental, and relational values of nature conducted for the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services, as part of the Methodological Assessment of the Diverse Values and Valuations of Nature. We identify the most frequently recurring meanings in the heterogeneous use of different v

Finding the dispersing siblings of young open clusters : Dynamical traceback simulations using Gaia DR3

Context. Stars tend to form in clusters, but many escape their birth clusters very early. Identifying the escaped members of clusters can inform us about the dissolution of star clusters, but also about the stellar dynamics in the galaxy. Methods capable of finding escaped stars from many clusters are required to fully exploit the large amounts of data in the Gaia era. Aims. We present a new metho

Quantum dot source-drain transport response at microwave frequencies

Quantum dots are frequently used as charge-sensitive devices in low-temperature experiments to probe electric charge in mesoscopic conductors where the current running through the quantum dot is modulated by the nearby charge environment. Recent experiments have operated these detectors using reflectometry measurements up to gigahertz frequencies rather than probing the low-frequency current throu