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In comparison to other human cancer types, malignant melanoma exhibits the greatest amount of heterogeneity. After DNA-based detection of the BRAF V600E mutation in melanoma patients, targeted inhibitor treatment is the current recommendation. This approach, however, does not take the abundance of the therapeutic target, i.e., the B-raf V600E protein, into consideration. As shown by immunohistoche

Upprinnelsen till detta specialnummer är frågan om hur dagens forskning om läsning och skrivning kan möta framtidens behov av undervisning för individen och i klassrummet. Både läsning och skrivning är komplexa aktiviteter, och för att vi till fullo ska förstå dem och kunna bidra till utveckling av skolans praktiker krävs att kunskaper från (ett antal) olika forskningsfält integreras.

Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF i

We evaluated the performance of CSF biomarkers for predicting risk of clinical decline and conversion to dementia in non-demented patients with cognitive symptoms. CSF samples from patients in two multicentre longitudinal studies (ADNI, n = 619; BioFINDER, n = 431) were analysed. Aβ(1–42), tTau and pTau CSF concentrations were measured using Elecsys CSF immunoassays, and tTau/Aβ(1–42) and pTau/Aβ(

The last decade has seen a range of studies using non-invasive neutron and X-ray techniques to probe the ultrastructure of a variety of photosynthetic membrane systems. A common denominator in this work is the lack of an explicitly formulated underlying structural model, ultimately leading to ambiguity in the data interpretation. Here we formulate and implement a full mathematical model of the sca

Passerine birds belong to the most species rich bird order and are found in a wide range of habitats. The extremely polymorphic adaptive immune system of passerines, identified through their major histocompatibility complex class I genes (MHC-I), may explain some of this extreme radiation. Recent work has shown that passerines have higher numbers of MHC-I gene copies than other birds, but little i

This work reports a method to select the optimal working frequency in transversal bulk resonator acoustophoretic devices by electrical impedance measurements. The impedance spectra of acoustophoretic devices are rich in spurious resonance peaks originating from different resonance modes in the system not directly related to the channel resonance, why direct measurement of the piezoelectric transdu

Background: Epilepsy patients commonly exercise less than the general population. Animal studies indicate beneficial effects of physical activity in established epilepsy, while its effect on the development is currently less known. Methods: Here, we investigated the incidence of epilepsy during 20 years in a cohort of participants from the long-distance Swedish cross-country ski race Vasaloppet (n

In epilepsy patients, drug-resistant seizures often originate in one of the temporal lobes. In selected cases, when certain requirements are met, this area is surgically resected for therapeutic reasons. We kept the resected tissue slices alive in vitro for 48 h to create a platform for testing a novel treatment strategy based on neuropeptide Y (NPY) against drug-resistant epilepsy. We demonstrate

Background: Computed tomography (CT) scans are routinely performed in positron emission tomography (PET) and single photon emission computed tomography (SPECT) examinations globally, yet few surveys have been conducted to gather national diagnostic reference level (NDRL) data for CT radiation doses in positron emission tomography/computed tomography (PET/CT) and single photon emission computed tom

In this paper, we study event-based PID control from an optimal stochastic control perspective. The purpose is to better understand what implementation features are critical for achieving good event-based PID performance. For this end, we formulate an LQG control design problem for a double integrator process with an integral disturbance, where the solution is an ideal PID controller. We then cons

A technique for scalable spray coating of colloidal CdSeTe quantum dots (QDs) for photovoltaics and photodetector applications is presented. A mixture solvent with water and ethanol was introduced to enhance the adhesive force between QDs and the substrate interface. The performance of the detector reached the highest values with 40 spray coating cycles of QD deposition. The photodetectors without

Groundwater is an important source to supply drinking water demands in both arid and semi-arid regions. Nevertheless, locating high quality drinking water is a major challenge in such areas. Against this background, this study proceeds to utilize and compare five decision tree-based data mining algorithms including Ordinary Decision Tree (ODT), Random Forest (RF), Random Tree (RT), Chi-square Auto

Humans learn new concepts extremely fast. One or two examples of a new concept are often sufficient for us to grasp its meaning. Traditional theories of concept formation, such as symbolic or connectionist representations, have problems explaining the quick learning exhibited by humans. In contrast to these representations, I advocate a third form of representing categories, which employs geometri

Linguistic awareness is seen as a development of linguistic abilities beyond what is needed for speech perception and production. According to another way of thinking, linguistic awareness is closely tied to cognitive development and reflects the change in cognitive functioning that is observed in children during middle childhood, approximately from four to eight years of age. Several suggestions