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Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and push
Background: This study investigates a broad spectrum of psychiatric disorders, substance use disorders, gambling, and internet gaming disorders in Swedish 18-year-old boys and girls with the aim of estimating the prevalence of disorders and comorbidity. Methods: We used a two-phase design with screening to detect candidates for clinical interviews. Screening included 949 adolescents (55.6% girls),
Många unga missgynnas av synen på kreativitet som en form av gudomlig inspiration.
the genus Diglyphomorphomyia Girault is newly reported from the Neotropical region, with the majority of material and species from Costa rica. It is represented by nine species in the region, and all are new species described here: D. albiclava, D. albicoxa, D. carinifer, D. costulata, D. cristata, D. metallica, D. parva, D. pedunculata, D. pilosa. An identification key for the species is included
Bacteria have evolved diverse immunity mechanisms to protect themselves against the constant onslaught of bacteriophages1-3. Similar to how eukaryotic innate immune systems sense foreign invaders through pathogen-associated molecular patterns4 (PAMPs), many bacterial immune systems that respond to bacteriophage infection require phage-specific triggers to be activated. However, the identities of s
The central aim of this thesis is to derive, implement and test new methods to calculate various types of spectroscopies of compounds containing heavy elements in an aqueous environment. Methods that can target such systems have to consider the following:(i) It is crucial to take relativistic effects into account.(ii) Modeling of larger systems is expensive in quantum chemistry. Thus, cheaper opti
Collective collapse occurs when a majority of the players in a team suddenly perform below expected level in a match, in spite of a satisfactory start, or when a team underperforms right from the start. Research results from a study on 146 male players and 15 coaches in various team sports at the elite level, and a study on a team involved in a collective collapse, and the opposite, a winning turn
Drawing from interviews with posters and an analysis of a dozen discussion threads on the Swedish online discussion forum Flashback, this article sets out to investigate the dramatization of crime news from the point of view of the participants themselves. Analyzing both the online discussions and the articulated motivations and activities of the posters, this article focuses on how participants i
Here, we report, for the first time, a microsporidian infection in laboratory-reared larvae of the damselfly Ischnura elegans. Infected larvae originated from field-collected adult females, which were caught in southern Poland in August 2020 (the second half of the flight season). Higher rearing temperatures and the presence of predator cues from the invasive alien signal crayfish (Pacifastacus le
One of the most recent definitions for a sandwich panel is the one used in the European product standard EN 14509. This product standard defines a sandwich panel as a building product consisting of two metal faces positioned on either side of a core that is a rigid thermally insulating material, which is firmly bonded to both faces so that the three components act compositely when under load. In m
Collaboration has the potential to strengthen both professional learning and well-being for teachers. However, it can also bring problematic aspects, such as increased workload and conflicts. The purpose of this study was to explore biology teachers’ experiences of collaboration to better understand how upper secondary school organisations can support teachers to obtain valuable collaborations. By
Optimization problems occur in many areas in science and engineering. When the optimization problem at hand is of large-scale, the computational cost of the optimization algorithm is a main concern. First-order optimization algorithms—in which updates are performed using only gradient or subgradient of the objective function—have low per-iteration computational cost, which make them suitable for t
This paper constructs a new chronology of the business cycle in the United Kingdom from 1700 on an annual basis and from 1920 on a quarterly basis to 2010. The new chronology points to several observations about the business cycle. First, the cycle has significantly increased in duration and amplitude over time. Second, contractions have become less frequent but are as persistent and costly as at
Remote sensing observations of variables related to vegetation at microwave and optical/infrared wavelengths are presented over three regions in Europe in the Iberian peninsula, northern Finland and central Europe. They include the instrumented sites of Las Majadas, Sodankyla and Reusel. The final goal is to better constrain land carbon cycle models using the complementarities of vegetation optica
Soil moisture (i.e., the changes in the gravimetric soil water content) redistribution is closely linked with root distribution and preferential flow in soils. This study aimed at exploring the soil water content distribution in the presence of root-enhanced preferential flow in deciduous (Quercus variabilis BI.) and coniferous forests (Platycladus orientalis (L.)).
A novel calculation methodology containing modeling and statistics was developed to assist the experimental process for the investigation of organics treatment process. A continuous-flow photo-electro treatment of Norfloxacin (NOR) was chosen as a target subject. The methodology is based on a new synergistic work of reaction energy calculation, full-scanned neural network (NN) simulation and new p
