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Although many nations in Sub-Saharan Africa (SSA) have recently recorded impressive economic growth, and several countries could attain middle-income status in the next decade, there is no or little concurrent advance in health biotech with little capabilities for manufacturing of medicines, medical supplies, and health commodities in the region. They import majority of medicines, medical supplies

Immunotherapy in cancer takes advantage of the exquisite specificity, potency, and flexibility of the immune system to eliminate alien tumor cells. It involves strategies to activate the entire immune defense, by unlocking mechanisms developed by tumor cells to escape from surrounding immune cells, as well as engineered antibody and cellular therapies. What is important to note is that these are t

An economic model for determining the optimal automation level for discrete batch manufacturing is presented. The model describes how the costs of parts varies between manufacturing systems of different types at differing automation levels, the part costs often being highly dependent upon the automation level selected. The optimal automation level in a given case can be determined using a relative

Background and Purpose: The EFFECTS (Efficacy of Fluoxetine - a Randomised Controlled Trial in Stroke) recently reported that 20 mg fluoxetine once daily for 6 months after acute stroke did not improve functional outcome but reduced depression and increased fractures and hyponatremia at 6 months. The purpose of this predefined secondary analysis was to identify if any effects of fluoxetine were ma

In the intermittent turning and milling processes, during the entry phase the cutting edges are subjected to high impact loads that can give rise to dynamical and strength issues which in general cause tool life reduction. In this study the effect of geometrical features of the cutting tool on the force generation during the entry phase is investigated. Cutting forces are measured by a stiff dynam

Tracking the tricuspid valve (TV) in magnetic resonance imaging (MRI) long-axis cine images has the potential to aid in the evaluation of right ventricular dysfunction, which is common in congenital heart disease and pulmonary hypertension. However, this annotation task remains difficult and time-demanding as the TV moves rapidly and is barely distinguishable from the myocardium. This study presen

Dynamic behavior and stability of system 'tool-workpiece' when machining HCCI with pCBN tools are determined by the processes which occur in cutting zone. The cutting process is characterized by formation of tool protection layer (TPL) on the chip contact area but its stability depends on the workpiece material composition, tool material and cutting conditions. The higher content of Si in the HCCI

Background: A histamine skin prick test (SPT) generally evokes a wheal and a flare. The present study was initiated by an observation that histamine did not evoke a flare around a wheal in the skin of an 86-year-old man. Could that be of relevance to the findings that old men are prone to a more severe COVD-19 infection with a higher mortality than young ones?. Materials and methods: Histamine SPT

Internal traverse grinding with electroplated cBN wheels using high-speed process conditions combines high material removal rates and a high surface quality of the workpiece in one single grinding stroke. In order to capture the macroscopic and mesoscopic thermo-mechanical loads onto the workpiece during internal traverse grinding, numerical simulations are conducted at the two scales. This result

Galectin-8 has gained attention as a potential new pharmacological target for the treatment of various diseases, including cancer, inflammation, and disorders associated with bone mass reduction. To that end, new molecular probes are needed in order to better understand its role and its functions. Herein we aimed to improve the affinity and target selectivity of a recently published galectin-8 lig

This paper analyzes the adoption of Additive Manufacturing (AM) technologies in Sweden. The dataset consists of a recent and representative sample of Swedish AM users (companies, universities, and research institutes). The authors investigate two questions. Firstly, what are the current applications of AM in Sweden (e.g. Rapid Prototyping (RP), production)? Secondly, what are the factors that can

Purpose: To compare the specificity of diagnosing posterior vitreous detachment (PVD) using preoperative optical coherence tomography (OCT) versus intraoperative triamcinolone acetonide (TA) staining in patients undergoing vitrectomy. Patients and Methods: This retrospective cohort study included patients undergoing pars plana vitrectomy for diverse retinal pathologies. Intraoperatively, surgeons

Semi-supervised learning (SSL) uses unlabeled data during training to learn better models. Previous studies on SSL for medical image segmentation focused mostly on improving model generalization to unseen data. In some applications, however, our primary interest is not generalization but to obtain optimal predictions on a specific unlabeled database that is fully available during model development

Over the past decade, as ruling Justice and Development Party (AKP) initiated Turkey’s authoritarian populist turn, it sought to derive legitimacy through extra-institutional avenues, notably the emotional appeal to the repressed “people”, advancing the party’s socio-political vision, countering the arguments of its political opponents and reaching out to, and inspiring its constituency. Turkey’s

Background: Coronary physiology is a routine diagnostic tool when assessing whether coronary revascularization is indicated. The iFR-SWEDEHEART trial demonstrated similar clinical outcomes when using instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) to guide revascularization. The objective of this analysis was to assess a cost-minimization analysis of iFR-guided compared with F

In recent years a concept gaining much traction amongst both economic and policy communities is that of Entrepreneurial Ecosystems (EE). We are interested in this concept because it has clear roots in innovation system thinking and can be argued to represent a contemporary iteration of ideas around systemic understandings and policy approaches to economic development, innovation, and entrepreneurs

Order-batching is an important methodology in warehouse material handling. This paper addresses three identified shortcomings in the current literature on order-batching optimization. The first concerns the overly large dependence on conventional warehouse layouts. The second is a lack of proposed optimization methods capable of producing approximate solutions in minimal computational time. The th

Two new protocols have been developed for bicycle exercise testing in chronic obstructive pulmonary disease (COPD) with an individualized cardiopulmonary exercise test (ICPET) and subsequent customized endurance test (CET), which generate less interindividual spread in endurance time compared with the standard endurance test. Main objectives of this study were to improve the prediction algorithm f

The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and results of a successful placebo-controlled clinical trial are presented.