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The Role of Maf Transcription Factors in Islet Inflammation and Βeta Cell Function

Endocrine disorders that lead to a state of chronic high blood glucose levels are collectively referred to as diabetes. This metabolic disease is mainly categorized into type 1 (T1D) and type 2 diabetes (T2D). These diabetic forms originate from distinct triggering environmental, genetic, and altered mechanisms. T2D is a consequence of metabolic load, peripheral insulin resistance, and failure of

Leishmaniasis in Sweden. Molecular, diagnostic and epidemiological studies of the parasite Leishmania in a non-endemic country.

Avhandlingen omfattar fyra delarbeten av olika slag, där två är rent laborativa studier av odlade Leishmaniaparasiter och deras interaktion med humant immunsvar, och två berör epidemiologi och diagnostik av sjukdomen leishmaniasis i ett svenskt patientmaterial.This doctoral thesis consists of four separate papers, in which we; investigate epidemiological and clinical aspects of leishmaniasis in Sweden in order to increase awareness of the disease, elucidate some aspects of the interaction of the parasite and the human immune system and validate serological tools as a complement for diagnosis of leishmaniasis.

Genetic predisposition, parity, age at first childbirth and risk for breast cancer

Background: Recent studies have identified several single-nucleotide polymorphisms (SNPs) associated with the risk of breast cancer and parity and age at first childbirth are well established and important risk factors for breast cancer. The aim of the present study was to examine the interaction between these environmental factors and genetic variants on breast cancer risk. Methods: The Malmö Die

Distribution of CGRP and CGRP receptor components in the rat brain

Background: Calcitonin gene-related peptide and its receptor, consisting of receptor activity-modifying protein 1 and calcitonin receptor-like receptor, are of considerable interest because of the role they play in migraine and recently developed migraine therapies. Methods: To better understand the function of this neuropeptide, we used immunohistochemistry to determine a detailed distribution of

Formation and growth of atmospheric nanoparticles in the eastern Mediterranean : Results from long-term measurements and process simulations

Atmospheric new particle formation (NPF) is a common phenomenon all over the world. In this study we present the longest time series of NPF records in the eastern Mediterranean region by analyzing 10 years of aerosol number size distribution data obtained with a mobility particle sizer. The measurements were performed at the Finokalia environmental research station on Crete, Greece, during the per

Management of congenital ichthyoses : European guidelines of care, part two

These guidelines for the management of congenital ichthyoses have been developed by a multidisciplinary group of European experts following a systematic review of the current literature, an expert conference held in Toulouse in 2016, and a consensus on the discussions. These guidelines summarize evidence and expert-based recommendations and intend to help clinicians with the management of these ra

Water Supply Challenges in Rural Areas : A Case Study from Central Kazakhstan

Rural water supplies have traditionally been overshadowed by urban ones. That must now change, as the Sustainable Development Goals calls for water for all. The objective of the paper is to assess the current access to and the perceived water quality in villages with various types of water supply. The survey was carried out during July⁻December 2017 in four villages in central Kazakhstan. Overall,

The (Im)Possibilities Of The Politics Of Solidarity: Human Rights Defenders Discourse, Humanitarian Aid Dynamics and Transmigrants Experiences In Mexico's Transit Assistance-Based Places.

Mexico has the most transited migratory corridor in the world . The complex migratory flows transiting the country—mainly Mexican, Central and South Amer- ican—have historically been perceived as economic and male . Scholars have not- ed as problematic the categorisation of the ‘labour migrant’ as being exclusive- ly voluntary. It has been demonstrated that framing agency through simplified unders

Single-center evaluation of a next generation fully repositionable and retrievable transcatheter aortic valve replacement

Background: The mechanically expandable Lotus Valve System is a fully repositionable and retrievable valve with an adaptive seal to minimize paravalvular leak (PVL). The aim of this study was to evaluate the short- and long-term safety and efficacy of the new device with focus on a new implantation technique to reduce the need for a permanent pacemaker (PPM) post procedure. Methods: We performed

The (Im)Possibilities of the Politics of Solidarity. Humanitariain Aid and Integral Support for Undocumented Transmigrants in Shelters in Mexico

Mexico is the most transited corridor in the world. Beyond borderlands, human rights abuses committed against migrants pervade across transit communities and routes. In the interior of Mexico, not only at borders, the criminalization of migration has occurred having as a backdrop violence, xenophobia and insecurity in transit communities. Transit communities have developed complex relationships wi

The clinical value of ERCP-guided cholangiopancreatoscopy using a single-operator system

Background: Single-operator, per-oral cholangiopancreatoscopy (SOPCP) enables direct biliopancreatic ductal visualization, targeted tissue sampling, and therapeutic intervention. At Karolinska University Hospital, SOPCP was introduced early and has since been extensively utilized according to a standardized protocol. We analysed the clinical value of SOPCP in the diagnosis and treatment of biliopa

REgistry-based randomized controlled trial of treatment and Duration and mortality in long-term OXygen therapy (REDOX) study protocol 11 Medical and Health Sciences 1102 Cardiorespiratory Medicine and Haematology

Objective: Long-term oxygen therapy (LTOT) during 15 h/day or more prolongs survival in patients with chronic obstructive pulmonary disease (COPD) and severe hypoxemia. No randomized controlled trial has evaluated the net effects (benefits or harms) from LTOT 24 h/day compared with 15 h/day or the effect in conditions other than COPD. We describe a multicenter, national, phase IV, non-superiority,

Shape and shell structure of lighter (N?90) neutron-rich nuclei based on a phenomenological Woods-Saxon potential

By using a phenomenologically successful Woods-Saxon potential, I study the shape and shell structure of (A) neutron drip line nuclei with 10≤N≤60, (B) neutron-rich nuclei related to the r process with 40≤N≤90, and (C) one-particle spectra in the potential provided by the nucleus Fe70 as a representative of so-called N=40 "island of inversion" (IoI) nuclei. First, the shell structure that is uniqu

Occupational exposure to inorganic particles during pregnancy and birth outcomes : A nationwide cohort study in Sweden

Objectives The aim of this study was to investigate if occupational exposure to inorganic particles or welding fumes during pregnancy is associated with negative birth outcomes. Design A prospective national cohort study. Setting All single births from 1994 to 2012 in Sweden. Information on birth weight, preterm birth, small for gestational age, smoking habits, nationality, age, occupation, absenc

2 breaking effects in 2-loop RG evolution of 2HDM

We investigate the effects of a ℤ 2 symmetry in the CP-conserving Two-Higgs-Doublet-Model (2HDM); which is often imposed to prevent Flavor-Changing-Neutral-Currents (FCNCs) at tree-level. Specifically, we analyze how a breaking of the ℤ 2 symmetry spreads during renormalization group evolution; employing general 2-loop renormalization group equations that we have derived. Evolving the model fro