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Quantitative analysis of mass spectrometry proteomics data : Software for improved life science

The rapid advances in life science, including the sequencing of the human genome and numerous other techiques, has given an extraordinary ability to aquire data on biological systems and human disease. Even so, drug development costs are higher than ever, while the rate of new approved treatments is historically low. A potential explanation to this discrepancy might be the difficulty of understand

Purchasing in Construction Companies

A significant part of the cost of a construction project, up to 90%, consists of purchased goods and services. Suppliers thereby have a large impact on the quality, price and time of projects. Purchasing management is therefore important for the outcome of a project. The aim of research covered by this thesis is to describe and analyse purchasing management and its interrelation with the supplier

‘Why not make films for New York?’ : The interaction between cultural, political and commercial perspectives in Swedish Film Policy 1963-2013

During the last two decades or so, film support, film policy and the public financing of audiovisual production in Scandinavia and particularly Sweden have undergone extensive transformation. In diverse ways, these changes can be seen as responses to globalization, to increased sub-national regional independence as well as to the emerging idea of nurturing ‘creative industries’ taking hold. They m

Nonlinguistic vocalizations from online amateur videos for emotion research : A validated corpus

This study introduces a corpus of 260 naturalistic human nonlinguistic vocalizations representing nine emotions: amusement, anger, disgust, effort, fear, joy, pain, pleasure, and sadness. The recognition accuracy in a rating task varied greatly per emotion, from 70% for amusement, pleasure, fear, and sadness. In contrast, the raters’ linguistic–cultural group had no effect on recognition accuracy:

Walking as a transport mode : Examining the role of preconditions, planning aspects and personal traits for the urban pedestrian

The overall aim of this thesis is to examine how walking as a transport mode is constructed in the planning realm, affected by the built environment and perceived by the individual. This aim is related to the following research questions: (1) How are pedestrians and walking understood, constructed and perceived in the planning context? (2) How does individual traits and the built environment affec

A framework for understanding purchasing in building construction

Purchasing on the part of a building construction company involves actors inside and outside the organization. These actors are driven by different motives that influence purchasing decisions in different situations. An explicit framework that assists in understanding the different purchasing situations would be of benefit to companies and researchers. Through a study of purchasing theory and pracPurchasing on the part of a building construction company involves actors inside and outside the organization. These actors are driven by different motives that influence purchasing decisions in different situations. An explicit framework that assists in understanding the different purchasing situations would be of benefit to companies and researchers. Through a study of purchasing theory and prac

Formation of Iduronic Acid during Chondroitin/Dermatan Sulfate Biosynthesis

All animals and some bacteria can synthesize linear polysaccharides with a backbone of repeating disaccharideunits, called glycosaminoglycans (GAGs). The GAGs are either attached to a protein core, as in proteoglycans (PGs), or exist as free polymer chains, as in hyaluronan. One of the most common types of GAGs is chondroitin/dermatan sulfate (CS/DS), where the repeating disaccharide backbone consAll animals and some bacteria can synthesize linear polysaccharides with a backbone of repeating disaccharideunits, called glycosaminoglycans (GAGs). The GAGs are either attached to a protein core, as in proteoglycans (PGs), or exist as free polymer chains, as in hyaluronan. One of the most common types of GAGs is chondroitin/dermatan sulfate (CS/DS), where the repeating disaccharide backbone cons

Editors’ Introduction : Conceptual Spaces at Work

This introductory chapter provides a non-technical presentation of conceptual spaces as a representational framework for modeling different kinds of similarity relations in various cognitive domains. Moreover, we briefly summarize each chapter in this volume.

Applications of Conceptual Spaces : the Case for Geometric Knowledge Representation

This volume provides an overview of applications of conceptual spaces theory, beginning with an introduction to the modeling tool that unifies the chapters. The first section explores issues of linguistic semantics, including speakers negotiation of meaning. Further sections address computational and ontological aspects of constructing conceptual spaces, while the final section looks at philosophi

Lakatos's challenge? : Auxiliary hypotheses and non-monotonous inference

Gerhard Schurz [2001, Journal for General Philosophy of Science, 32, 65-107] has proposed to reconstruct auxiliary hypothesis addition, e.g., postulation of Neptune to immunize Newtonian mechanics, with concepts from non-monotonous inference to avoid the retention of false predictions that are among the consequence-set of the deductive model. However, the non-monotonous reconstruction retains the

Monotonicity and reasoning with exceptions

A proposal by Ferguson [2003, Argumentation 17, 335-346] for a fully monotonic argument form allowing for the expression of defeasible generalizations is critically examined and rejected as a general solution. It is argued that (i) his proposal reaches less than the default-logician's solution allows, e.g., the monotonously derived conclusion is one-sided and itself not defeasible. (ii) when appli