During the last decade the variation in the human genome has been mapped in fine detail. Next generation sequencing has made it possible to cheaply and rapidly aquire vast amounts of biomolecular information on large cohorts of people. This have enabled large-scale epidemiological studies to investigate the relationships between environmental and genetic factors and human biomolecular traits. It i

The neurodegenerative Huntington's disease (HD) is caused by a polyglutamine (polyQ) amplification in the huntingtin protein (HTT). Currently there is no effective therapy available for HD; however, several efforts are directed to develop and optimize HTT-lowering methods to improve HD phenotypes. To validate these approaches, there is an immediate need for reliable, sensitive, and easily accessib

Background: Although reduced lung function is associated with both COPD and coronary events (CE), the pattern of lung function impairment could be different for the two outcomes. We examined different measures of lung function in relation to incident COPD events and CE in a population-based cohort. Methods: Baseline spirometry and lung clearance index (LCI) were assessed in 672 men aged 55 years.

We have investigated the photoionization and photofragmentation yields of gas-phase multiply protonated melittin cations for photon energies at the K-shell absorption edges of carbon, nitrogen, and oxygen. Two similar experimental approaches were employed. In both experiments, mass selected [melittin+qH]q+ (q=2–4) ions were accumulated in radiofrequency ion traps. The trap content was exposed to i

BACKGROUND: Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are recommended as part of first-line treatment for HIV-1 in Africa. However, NNRTI-based regimens are more prone to resistance development than protease inhibitors (PIs) in a context in which drug interruptions are frequent. The aim of this study was to compare the efficacy and tolerability of NNRTIs with PIs in HIV-1-infected pa

We have developed a compact hyperspectral lidar system based on a continuous-wave (CW) 445 nm diode laser and a double Scheimpflug imaging arrangement. The light-weight construction allows the integration of the system on a commercial drone. Airborne, range-resolved spatial imaging of vegetation fluorescence is demonstrated.

OBJECTIVE: To evaluate speech in 5-year-olds with cleft palate with or without cleft lip (CP±L) treated with primary palatal surgery in 1 stage with muscle reconstruction according to Sommerlad at about 12 months of age.DESIGN: Retrospective study.SETTING: Primary care university hospital.PARTICIPANTS: Eight 5-year-olds with cleft soft palate (SP), 22 with cleft soft/hard palate (SHP), 33 with uni

Background: Admission lactate and lactate clearance are implemented for risk stratification in sepsis and trauma. In out-of-hospital cardiac arrest, results regarding outcome and lactate are conflicting. Methods: This is a post-hoc analysis of the Target Temperature Management trial in which 950 unconscious patents after out-of-hospital cardiac arrest were randomized to a temperature intervention

This study re-examines standard econometric approaches for detecting adverse and advantageous selection in insurance contracts based on variables that are not used for calculating the insurance premium. We formally demonstrate that existing strategies for detecting selection based on such ‘unused characteristics’ can lead to incorrect conclusions if the estimated coefficients of interest are drive

We propose and analyze distributed computation algorithms for finite-horizon optimal control problems in transportation networks. We model traffic flow dynamics by the cell-transmission model and focus on two problems: system-optimum dynamic traffic assignment (where the routing is part of the optimization) and freeway network control (where the routing is exogenous and the optimization is confine

Magmatism of the Povungnituk Group of the Cape Smith Belt, northern Superior craton, was formed in three stages: (i)early alkaline magmatism and associated carbonatites (undated), (ii) a main flood basalt sequence (Beauparlant Formation) (constrained between 2040 and 1991 Ma), and (iii) a late stage alkaline pulse (Cecilia Formation) (ca. 1959 Ma). We suggest that the main stage of magmatic activi

Measurement of biosphere-atmosphere exchange of various greenhouse gases requires different techniques. In case of carbon dioxide, the net ecosystem exchange (NEE) is usually measured by the eddy covariance method. In the lack of these measurements in forests, the carbon dioxide uptake can be estimated by detecting changes in sequestrated carbon stocks or by using tree growth (dendrometric) measur

The optimal follow-up (FU) strategy for patients treated for localised renal cell carcinoma (RCC) remains unclear. Using the RECUR database, we studied imaging intensity utilised in contemporary FU to evaluate its association with outcome after detection of disease recurrence. Consecutive patients with nonmetastatic RCC (n = 1612) treated with curative intent at 12 institutes across eight European

Gösta Werner (1908–2009) var en svensk filmpionjär som i rollen som redaktör, regissör och forskare gjorde starkt avtryck på den offentliga debatten om filmen som konstform. Genom att studera denna framträdande filmpersonlighets texter och filmer belyser avhandlingen ett antal viktiga kulturpolitiska strider inom den framväxande svenska konstfilmsinstitutionen, däribland om filmstudiets formering,

The seasonal phenology of the leaf area index (LAI) is a major determinant of net ecosystem production in deciduous forest ecosystems. This study describes seasonal and inter-annual differences in LAI in a boreal aspen-hazelnut forest in central Saskatchewan, Canada, between 1994 and 2003, and relates the differences in LAI to annual net ecosystem production (FNEP). A robust method is developed to

Three different, state-of-the-art biogeochemical models are adapted in order to quantify the carbon dioxide (CO2), nitrous oxide (N 2O), and methane (CH4) exchanges between arable lands and the atmosphere. Biome-BGC and MOD17 are validated using the long-term measurement results from Hegyhátsál tall tower site (Western Hungary). After a simple bias correction, it was found that Biome-BGC is capabl

Background: Oxygen is liberally administered in intensive care units (ICUs). Nevertheless, ICU doctors’ preferences for supplementing oxygen are inadequately described. The aim was to identify ICU doctors’ preferences for arterial oxygenation levels in mechanically ventilated adult ICU patients. Methods: In April to August 2016, an online multiple-choice 17-part-questionnaire was distributed to 10

OBJECTIVES: To evaluate knowledge translation after publication of the target temperature management 33°C versus 36°C after out-of-hospital cardiac arrest trial and associated patient outcomes. Our primary hypothesis was that target temperature management at 36°C was rapidly adopted in Australian and New Zealand ICUs. Secondary hypotheses were that temporal reductions in mortality would be seen an