The prevalence of obesity has reached pandemic proportions, and now approximately 25% of adults in Westernized countries have obesity. Recognized as a major health concern, obesity is associated with multiple comorbidities, particularly cardiometabolic disorders. In this Review, we present obesity as an evolutionarily novel condition, summarize the epidemiological evidence on its detrimental cardi

Although masculinity is a powerful concept in both sociology and gender studies, previous research forgot to analyse sex work under this perspective. Even though the actors involved are men, and previous studies have highlighted the importance of masculinity not only in the relation manto- woman but also in the “gay world”, there is a lack of attention in male sex working. Then, the aim of this pa

This chapter analyses an unexplored field of study: male sex workers. Indeed, while their female counterparts have been widely researched, there is a lack of attention on men who sell sex. For this reason, we aim to (re)shape the representations, theories, rhetoric, organisation, and types of male sex work as a complex, uncomfortable, and controversial phenomenon. First we engage with a social his

Aggrecan (ACAN) is localized in the intervertebral disc (IVD) in unique compartment-specific patterns where it contributes to the tissue structure and mechanical function together with collagens. The extracellular matrix (ECM) of the IVD undergoes degenerative changes during aging, misuse or trauma, which inevitably alter the biochemical and biomechanical properties of the tissue. A deeper underst

Introduction: Venous thromboembolism (VTE) is a complex disease that aggregates in families. Both acquired and genetic risk factors are important. Proper recognition and management of high-risk individuals are important. Areas covered: The genetic risk factors for VTE, the clinical consequences, and future perspectives are summarized. Classical thrombophilia i.e., factor V Leiden (rs6025), the pro

SF3B1 is the most mutated splicing factor (SF) in myelodysplastic syndromes (MDSs), which are clonal hematopoietic disorders with variable risk of leukemic transformation. Although tumorigenic SF3B1 mutations have been extensively characterized, the role of “non-mutated” wild-type SF3B1 in cancer remains largely unresolved. Here, we identify a conserved epitranscriptomic program that steers SF3B1

The physiological performance of organisms depends on their environmental context, resulting in performance–response curves along environmental gradients. Parasite performance–response curves are generally expected to be broader than those of their hosts due to shorter generation times and hence faster adaptation. However, certain environmental conditions may limit parasite performance more than t

Purpose: To demonstrate the feasibility and accuracy of chemical shift–encoded imaging of the fatty acid composition (FAC) of human bone marrow adipose tissue at 7 T, and to determine suitable image-acquisition parameters using simulations. Methods: The noise performance of FAC estimation was investigated using simulations with a range of inter-echo time, and accuracy was assessed using a phantom

Background: Community-based day centres (DC) in Sweden provide support to people with severe mental health problems. The role of DC motivation for outcomes in terms of occupational engagement and personal recovery is yet unknown. Aims: To compare two groups who received DC services, one of which also received the 16-week Balancing Everyday Life (BEL) intervention. The focus was motivation for DC s

The aim was to explore existential loneliness in different long-term care contexts as narrated by older people. A qualitative secondary analysis was performed of 22 interviews with older people in residential care, home care, and specialized palliative care. The analysis started with naive reading of interviews from each care context. As these readings showed similarity with Eriksson’s theory of t

Despite aggressive treatment, the 5-year event-free survival rate for children with high-risk neuroblastoma is

Antibodies play a central role in the immune defense against SARS-CoV-2. Emerging evidence has shown that nonneutralizing antibodies are important for immune defense through Fc-mediated effector functions. Antibody subclass is known to affect downstream Fc function. However, whether the antibody subclass plays a role in anti-SARS-CoV-2 immunity remains unclear. Here, we subclass-switched eight hum

We coordinate interconnected agents where the control input of eachagent is limited by the control input of others. In that sense, the sys-tems have to share a limited resource over a network. Such problems canarise in different areas and it is here motivated by a district heating ex-ample. When the shared resource is insufficient for the combined needof all systems, the resource will have to be s

Införandet av människoexploateringsbrottet i 4 kap. 1 b § BrB aktualiserar ett antal frågor som tidigare inte behandlats i praxis. Bestämmelsen prövades för första gången av Högsta domstolen i NJA 2022 s. 23, vilket är det avgörande denna artikel kommenterar. Författaren visar att domstolen ställt upp en ordning för hur prövningen ska gå till, diskuterar innebörden av rekvisitet exploatering samt

INTRODUCTION Worldwide every third women is exposed to physical and/or sexual violence and pregnancy is no safe period for the women. The aim was to elucidate midwives experience of violence-exposed pregnant women who had been referred to a prenatal ward and were hospitalized. METHODS An inductive qualitative method was used with four focus-group interviews performed with sixteen midwives working

Dental professionals and dental patients are exposed to the same sensitizers, but the outcome is very different. Dental professionals suffer predominantly from irritant contact dermatitis and to a lesser degree from allergic contact dermatitis to acrylates and rubber products. Dental patients rarely have allergic contact stomatitis. In this chapter, the reader will learn about the multiple factors