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The Expansion of Colonial State Healthcare in Twentieth Century British Africa

We chart and assess the scope and utilisation of government-provided hospital infrastructure in British Africa, c. 1900-1960. Using various archival sources, we examine the heterogeneity in colonial administrations’ investment into curative healthcare provision across various regions of British Africa. Our research highlights significant disparities in healthcare provision during the colonial peri

Prevalence and size of pelvic sentinel lymph node metastases in endometrial cancer

Aim of the study: To assess the association of prevalence and size of pelvic sentinel node (SLN) metastases with risk factors in endometrial cancer (EC). Patients and Methods: Between June 2014 and January 2024 consecutive women with a uterine confined EC undergoing robotic surgery including detection of pelvic SLNs at a University Hospital were included. An anatomically based algorithm utilizing

Screening and management of hypertensive patients with chronic kidney disease referred to Hypertension Excellence Centres among 27 countries. A pilot survey based on questionnaire

Objective: Real-life management of hypertensive patients with chronic kidney disease (CKD) is unclear. Methods: A survey was conducted in 2023 by the European Society of Hypertension (ESH) to assess management of CKD patients referred to ESH-Hypertension Excellence Centres (ESH-ECs) at first referral visit. The questionnaire contained 64 questions with which ESH-ECs representatives were asked to e

Tracking of charged particles with nanosecond lifetimes at LHCb

A method is presented to reconstruct charged particles with lifetimes between 10ps and 10ns, which considers a combination of their decay products and the partial tracks created by the initial charged particle. Using the Ξ- baryon as a benchmark, the method is demonstrated with simulated events and proton-proton collision data at s=13TeV, corresponding to an integrated luminosity of 2.0fb-1 collec

PET-CT imaging of neuroendocrine tumours - Beyond diagnostics

Background: Neuroendocrine tumours (NETs) typically overexpress somatostatin receptors. By radiolabelling somatostatin analogues with a positron-emitting radionuclide (68Ga-DOTATOC or 68Ga-DOTATATE), these tumours can be detected with high sensitivity and specificity using somatostatin receptor positron emission tomography-computed tomography (PET-CT).Aim: To enhance knowledge about NETs imaged wi

Deep learning analysis of serial digital breast tomosynthesis images in a prospective cohort of breast cancer patients who received neoadjuvant chemotherapy

Purpose: Different imaging tools, including digital breast tomosynthesis (DBT), are frequently used for evaluating tumor response during neoadjuvant chemotherapy (NACT). This study aimed to explore whether using artificial intelligence (AI) for serial DBT acquisitions during NACT for breast cancer can predict pathological complete response (pCR) after completion of NACT. Methods: A total of 149 wo

Obesity and its association with self-efficacy and metabolic risk factors by region of birth among 40-year-olds participating in the Swedish targeted health dialogues

Objective: Targeted Health Dialogues (THD) is a public health intervention program that aims at preventing cardiovascular disease. THDs were implemented in the Swedish region Scania, in 2020, with the novelty of being conducted in a metropolitan area with a multiethnic population. This study investigated the prevalence of obesity among 40-year-old THD participants in Scania by region of birth, and

The Early Perfusion Image Is Useful to Support the Visual Interpretation of Brain Amyloid-PET With 18F-Flutemetamol in Borderline Cases

Purpose Visual interpretation of brain amyloid-β (Aβ) PET can be difficult in individuals with borderline Aβ burden. Coregistration with individual MRI is recommended in these cases, which, however, is not always available. This study evaluated coregistration with the early perfusion frames acquired immediately after tracer injection to support the visual interpretation of the late Aβ-frames in PE

Iron-rich Ca–Mg skarns from the SW East European Craton (Lithuania) : Microstructural study, mineral reactions and direct age constraints of ore-forming events using LA-ICPMS

The Varena Iron Ore deposit in the SW East European Craton is a significant ore body that occurs within metamorphosed and hydrothermally reworked Paleoproterozoic dolostones. We have performed microstructural investigations supplemented with mineral chemistry and geochronological investigations (LA-ICP-MS) to obtain age constraints on the ore-forming event(s) and improve the understanding of the c

Gender and Care between Bonus/step-grandparents and bonus/step-grandchildren

Almost half of all divorced Swedes are aged 60+ and many of them are, or have been, part of a reconstituted family. This increases the probability of having (or to be a) bonus/step-grandchild and raises the question: How does the caregiving dynamic between bonus-grandparents and bonus-grandchildren intersect with gender and life situation, unraveling the intricate threads that weave through familiAlmost half of all divorced Swedes are aged 60+ and many of them are, or have been, part of a reconstituted family. This increases the probability of having (or to be a) bonus/step-grandchild and raises the question: How does the caregiving dynamic between bonus-grandparents and bonus-grandchildren intersect with gender and life situation, unraveling the intricate threads that weave through famili

Neuronal and glial responses to dopaminergic denervation

Parkinson's disease (PD) is characterised by severe degeneration of dopamine (DA) neurons innervating the striatum. Spiny projection neurons (SPNs), are the principal type of striatal neuron and belong to either of two classes: the D2 receptor-positive indirect pathway SPNs (iSPNs) and the D1 receptor-positive direct pathway SPNs (dSPNs). The thesis aims at investigating dynamic changes of SPNs an