Noncoding variants at human chromosome 9p21 near CDKN2A and CDKN2B are associated with type 2 diabetes(1-4), myocardial infarction(5-7), aneurysm(8), vertical cup disc ratio(9) and at least five cancers(10-16). Here we compare approaches to more comprehensively assess genetic variation in the region. We carried out targeted sequencing at high coverage in 47 individuals and compared the results to

All commercially available upper limb prosthesis controllers only allow the hand to be commanded in an open and close fashion without any sensory feedback to the user. Here the evaluation of a multi-degree of freedom hand controlled using a real-time EMG pattern recognition algorithm and incorporating a sensory feedback system is reported. The hand prosthesis, called SmartHand, was controlled in r

In this study, two experiments were conducted to evaluate the impact of substrate concentrations on methane potential and degradation kinetics of substrate. The biochemical methane potential (BMP) tests in Experiment I were performed at a constant inoculum to substrate ratio (ISR), whereas, different ISRs were applied in Experiment II. Results obtained from Experiment I revealed that methane poten

In a previous study, we found urinary excretion of Tamm-Horsfall protein (THP) to be persistently decreased in 25% of patients during the first year after diagnosis of diabetes mellitus. We thus wanted to study another marker for distal tubular function, pi glutathione S-transferase (pi-GST) and compare this and THP with proximal tubular function evaluated with alpha-GST and alpha-1-microglobulin

Background: Novel peritoneal dialysis solutions are characterized by a minimal content of glucose degradation products and a neutral pH. Many studies have shown the biocompatibility of neutral lactate-buffered solutions; however, until now, the effect of purely bicarbonate-buffered solutions has not been intensively studied in vivo. Methods: This study was an open label, prospective, crossover mul

Contributing to a growing literature on democracy beyond the nation-state, this article draws on aspects of national democratization theory in order to analyse empirical processes of democracy. By combining insights from transition theory and the theory of political opportunity structures, the article examines the case of the Asian Development Bank (ADB). While the ADB for a long time has been des

Large scientific projects present new technological challenges, such as the distributed control over a communication network. In particular, the middleware Experimental Physics and Industrial Control System (EPICS) is the most extended communication standard in particle accelerators. The integration of modern control architectures in these EPICS networks is becoming common, as for example for the

Supported by a virtual plethora of impact evaluations, conditional cash transfers (CCTs) have been widely promoted for their ability to simultaneously pursue short-term poverty alleviation through income support and long-term poverty reduction through human capital investments. In particular, their claim to fame lies in their perceived capacity to enable a break in intergenerational transmission o

Abstract in Undetermined The editorial introduces the special issue on film workshops, situating the workshops as minor cinemas, and discussing the revised historiography of film.

Inom psykologi och etnologi studeras företeelser ur perspektiv som återfinns hos den enskilda individen samt i det lokala eller sociala sammanhanget. I studien har olika styrmedel bedömts från ett etnologiskt och psykologiskt perspektiv. Studien har därvid inneburit nya arbetsmetoder – i varken psykologi eller etnologi brukar man arbeta med att förutsäga hur olika medel (t.ex. styrmedel) påverkar

Highest resolution imaging in astronomy is achieved by interferometry, connecting telescopes over increasingly longer distances and at successively shorter wavelengths. Here, we present the first diffraction-limited images in visual light, produced by an array of independent optical telescopes, connected electronically only, with no optical links between them. With an array of small telescopes, se

Laminar burning velocities of acetone + air mixtures at initial gas mixture temperatures of 298, 318, 338 and 358 K are reported. Non-stretched flames were stabilized on a perforated plate burner at 1 atm, and laminar burning velocities were determined using the heat flux method, at conditions where the net heat loss from the flame to the burner is zero. The overall accuracy of the burning velocit

The annealing-induced formation of (Mn, Ga)As nanocrystals in (Ga, Mn)As/GaAs superlattices was studied by x-ray diffraction, transmission electron microscopy and magnetometry. The superlattice structures with 50 Å thick (Ga, Mn)As layers separated by 25, 50 and 100 Å thick GaAs spacers were grown by molecular beam epitaxy at low temperature (250 ° C), and then annealed at high temperatures of 400

Background: To investigate hand bone loss (HBL) measured by digital X-ray radiogrammetry (DXR) in patients with early rheumatoid arthritis (RA) receiving different treatment regimens, and to evaluate if DXR change rates during the first 12 months correlate with radiological damage after 24 months. Methods: From the total SWEFOT trial population, 159 patients had hand radiographs correctly timed an

The aim of this study was to investigate the possibility to produce novel powder materials based on chemically modified starch granule stabilized Pickering oil-in-water (O/W) emulsions. This study also investigated the effect of partial starch gelatinization in situ, dispersed phase type (two oil types with different melting points), freezing method and thawing, and freeze-drying and rehydrating o