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Anti-rheumatic treatment and prosthetic joint infection : An observational study in 494 elective hip and knee arthroplasties

Background: Surgical site infections are more frequent among patients with rheumatic disease. To what extent this is related to immunosuppressive antirheumatic drugs is unclear, as is the value of discontinuing medication perioperatively. The aim of study was to assess the rate of surgical site infections after knee and hip replacement in patients with inflammatory joint disease, with an emphasis

Countergradient Variation in Reptiles : Thermal Sensitivity of Developmental and Metabolic Rates Across Locally Adapted Populations

Environmental temperature is a key driver of variation in developmental physiological rates in reptiles. Cooler temperatures extend development time and can increase the amount of energy required to achieve hatching success, which can pose fitness consequences later in life. Yet, for locally-adapted populations, genetic variation can oppose environmental variation across ecological gradients, know

Experimental methods for measuring the breakup frequency in turbulent emulsification : A critical review

The growing interest in using population balance modeling to describe emulsification processes has spurred an interest in experimentally measuring the breakup frequency. This contribution classifies, compares, and critically reviews the different methods that have been suggested for measuring the breakup frequency, applicable to emulsification devices. Two major approaches can be seen in previous

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Critical discussion of proposed Dutch real estate tax exemption for first time home buyers and the negative effects for the housing market and equality of the existing gift tax exemption related to residential real estate.

Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells

Growing evidence demonstrates that human mesenchymal stromal cells (MSCs) modify their in vivo anti-inflammatory actions depending on the specific inflammatory environment encountered. Understanding this better is crucial to refine MSC-based cell therapies for lung and other diseases. Using acute exacerbations of cystic fibrosis (CF) lung disease as a model, the effects of ex vivo MSC exposure to

Epigenome-wide gene-age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients

DNA methylation changes during aging, but it remains unclear whether the effect of DNA methylation on lung cancer survival varies with age. Such an effect could decrease prediction accuracy and treatment efficacy. We performed a methylation-age interaction analysis using 1,230 early-stage lung adenocarcinoma patients from five cohorts. A Cox proportional hazards model was used to investigate lung

A Novel Major Output Target for Pheromone-Sensitive Projection Neurons in Male Moths

Even though insects have comparably small brains, they achieve astoundingly complex behaviors. One example is flying moths tracking minute amounts of pheromones using olfactory circuits. The tracking distance can be up to 1 km, which makes it essential that male moths respond efficiently and reliably to very few pheromone molecules. The male-specific macroglomerular complex (MGC) in the moth anten

Non-homogeneous magnetic permeability and magnetic steps within the Ginzburg–Landau model

We study the Ginzburg–Landau model in the frame of non-homogeneous magnetic permeabilities and non-homogeneous applied magnetic fields. We establish a continuity result with respect to the applied magnetic field and the magnetic permeability coefficient, thereby motivating the consideration of a discontinuous magnetic field/permeability within the sample. We then study the model in the regime of a

Tracing KEGR

As a researcher, I have spent countless hours hunting for tags. Recently, I started thinking about ways to represent not just my physical search, but also the thought process taking place alongside the visible bodily activities: remembering – for example – the style, medium, size and placement of previous tags of interest in order to better spot similar tags and their likely locations.This video i

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The treatment of rheumatoid arthritis is currently based on pathogenesis and pathophysiology, being the etiology still unknown. At cognition and activation phase of rheumatoid arthritis, there is a number of potential therapeutic approaches, still in development and in early trials. At inflammation and even more at invasive phase of rheumatoid arthritis, the treatment should take into consideratio

Contrast sensitivity and the detection of moving patterns and features

Theories based on optimal sampling by the retina have been widely applied to visual ecology at the level of the optics of the eye, supported by visual behaviour. This leads to speculation about the additional processing that must lie in between-in the brain itself. But fewer studies have adopted a quantitative approach to evaluating the detectability of specific features in these neural pathways.

Evolutionary consequences of multidriver environmental change in an aquatic primary producer

Climate change is altering aquatic environments in a complex way, and simultaneous shifts in many properties will drive evolutionary responses in primary producers at the base of both freshwater and marine ecosystems. So far, evolutionary studies have shown how changes in environmental drivers, either alone or in pairs, affect the evolution of growth and other traits in primary producers. Here, we

After 25 Years as Faithful Members of the EU. Public Support for the Euro and Trust in the ECB in Austria, Finland and Sweden

Austria, Finland and Sweden became members of the EU in 1995. This paper examines how support for the euro and trust in the European Central Bank (ECB) have evolved in these three countries since their introduction at the turn of the century. Support for the euro in the two euro-area members Austria and Finland has remained high and relatively stable since the physical introduction of the new curr

Experimental and numerical investigations on the hybrid dowel and bonding steel plate joints for timber structures

This paper summarizes the experimental and numerical investigations on an innovative hybrid joint for timber structures. A total of 12 hybrid dowel and bonding steel plate joints divided in four subgroups were investigated. Different parameters such as the presence of self-tapping screws and the surface treatment of the bonding steel plate, were studied. For two subgroups, a vulcanized rubber laye