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Background: Firm recommendations about the way thiopurine drugs are introduced and the use of thiopurine methyltransferase (TPMT) and metabolite measurements during treatment in inflammatory bowel disease (IBD) are lacking. Aim: To evaluate pharmacokinetics and tolerance after initiation of thiopurine treatment with a fixed dosing schedule in patients with IBD. Patients: 60 consecutive patients wi

Enterohemorrhagic Escherichia coli produce an attaching and effacing lesion upon adhering to the intestinal epithelium. Bacterial factors involved in this histopathology include the intimin adhesin and E. coli secreted proteins (Esps) A and B. In this study we investigated the serum antibody responses to recombinant E. coli O157:H7 intimin, EspA, and EspB by immuno-blotting. Canadian patients with

TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) has a potency to induce decreased fertility and structural reproductive anomalies in male and female mammals. While the activity profile of sex steroid hormone production distinctly differs in developing males and females, we wanted to analyze sex-specific effects of TCDD introduced in utero and via lactation on gonadal steroidogenesis and gonadotropin le

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An extended table of Shuurman's bounds on the state complexity of short binary linear codes is presented. Some new lower and upper bounds are obtained. Most of the newly found codes are based on the so-called double zero-tail termination (DZT) construction

The paper describes the influence exercised by professor Kjell Granström in the teaching of psychology. Among pedagogical inventions inspired by Granström are to be found training in small group obesrvation in a laboratory format the use of group diaries, training in consultation. The importance of a close connection between research and teaching is discussed.

Intervju med Roy Andersson om både hans tidigare karriär men främst om hans då aktuella film Sånger från andra våningen

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When ferrochromium is produced at Vargon Alloys AB (Vargon, Sweden), an offgas dust is generated as a byproduct. A leachate that contains hexavalent chromium (Cr6+) is formed when rainwater percolates through the dust deposit. In this study, Cr6+ in the leachate was reduced to trivalent chromium (Cr3+) by biological treatment in a biofilm process operated under anaerobic conditions. The reactor vo

Solitary bees and bumblebees have declined substantially throughout western Europe during the last 100 years. Many species are important pollinators and are associated with particular plant species and habitats. In this study we report the highest number of bee species found at one locality in Sweden (Table 2). In total 87 species of wild bees (74 species of solitary bees and 13 species of bumble

The influence of electron doping, via deposition of small amounts of Cs, on the electronic structure of has been studied by high-resolution photoelectron spectroscopy (PES) and x-ray absorption spectroscopy (XAS), utilizing synchrotron radiation. The changes in the electronic structure were monitored by PES of the valence band and of the O 1s, Bi 4f, Bi 5d, Ca 2p and Sr 3d core levels, and by XAS

Toluidine Blue O (TBO) was covalently bound on silica gel and mixed with graphite powder and paraffin oil to produce modified carbon paste electrodes. The formal potential (E°′) of the covalently bound TBO was found to be −100 mV versus Ag|AgCl (KCl sat.) at pH 7.0 and the E°′ varied less than anticipated for a 2-electron–proton type mediator with pH. The bound TBO was found to act as an efficient