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In vivo gene therapy for neurodegenerative disorders has turned out to be a formidable challenge. It is a field not much older than twenty years, but we were many who would have predicted a much easier path towards the clinic using this treatment modality. For Parkinson's disease patients, this has meant a frustrating wait, seeing many promising therapies being forgotten after a few pre-clinical p
This paper presents the evaluation of a method supporting the integration of packaging development into product development through the use of an assessment framework for methodologies under development. While the evaluation of the integration method itself is critical for its further development the main objective is to use this evaluation as a further testing of the assessment framework. The ass
In an earlier paper, I set out to apply to animal mimicry the definition of the sign, and, more specifically, of the iconic sign, which I originally elaborated in the study of pictures, and which was then extended by myself and others to language, gesture, and music. The present contribution, however, while summarizing some of the results of those earlier studies, is dedicated to the demonstration
The research framework of eco-evolutionary dynamics is increasing in popularity, as revealed by a steady stream of review articles and a recent and influential book, but primary empirical research is lagging behind. Moreover, the few empirical case studies demonstrating eco-evolutionary dynamics might not be entirely representative. Much current research on eco-evolutionary dynamics is focused on
These guidelines for the management of congenital ichthyoses have been developed by a multidisciplinary group of European experts following a systematic review of the current literature, an expert conference held in Toulouse in 2016 and a consensus on the discussions. They summarize evidence and expert-based recommendations and are intended to help clinicians with the management of these rare and
PURPOSE: To increase knowledge about pain and general health in adults with myelomeningocele, a health condition with several risk factors for pain such as musculoskeletal deformities, shunt dysfunctions, bowel problems, and urinary tract infections/stones. METHODS: Descriptive correlational pilot study (N= 51, 53% males). Chi-square tests were used to test associations among presence, impact, sev
The sparsity of the isotope Helium-3, ongoing since 2009, has initiated a new generation of neutron detectors. One particularly promising development line for detectors is the multilayer gaseous detector. In this paper, a stochastic process approach is used to determine the neutron energy from the additional data afforded by the multilayer nature of these novel detectors. The data from a multilaye
Background: A consistent proportion of individuals at risk for Alzheimer's disease show intact cognition regardless of the extensive accumulation of amyloid-β (Aβ) peptide in their brain. Several pieces of evidence indicate that overactivation of brain regions negative for Aβ can compensate for the underactivation of Aβ-positive ones to preserve cognition, but the underlying synaptic changes are s
Objective: Glucose dysregulation is an independent risk factor for cardiovascular and neurodegenerative disease development through synaptic dysfunction resulting in cognitive decline. The aim of this study was to study the interplay between impaired glycaemic metabolism (hyperglycaemia and insulin resistance), cardiac stress (cardiac troponin T and N-terminal brain natriuretic peptide) and execut
Aims: Lewy body diseases are neuropathologically characterized by the abnormal accumulation of α-synuclein (α-syn) protein within vulnerable neurons. Although studies have evaluated α-syn in post mortem brain tissue, previous findings have been limited by typically employing pan-α-syn antibodies that may not recognize disease-relevant forms of protein. We investigated the presence of α-syn species
CEQ-resultaten för en del projektbaserade kurser visar att studenterna upplever att kursens mål inte är tydliga (skalan "Tydliga mål", TM, i CEQ). Studenterna verkar således vara ganska osäkra på vad lärarna förväntar sig av dem. Detta är ett problem som kräver uppmärksamhet, eftersom otydliga mål och förväntningar kan vara en anledning till frustration, oro och onödig stress hos studenterna, även
Neck-banded Greylag Geese Anser anser from a population breeding in southwest Scania, southern Sweden, were studied to assess changes in the breeding population and breeding performance during 1984–2013. The population increased ten-fold during this period, only to decrease again in the later years of the study. Greylag Geese arrived on the breeding grounds about 3–4 weeks earlier by 2007–2009 com
Objective: To analyze the midterm result of in situ fenestration (ISF) of the left subclavian artery (LSA) during thoracic endovascular aneurysm repair (TEVAR). Methods: In this clinical study, between 2014 and 2016, ISF for LSA revascularization was attempted during TEVAR in 10 patients (7 males; median age, 68 years). An excimer laser, placed from the left brachial artery, was used to create a f
Neuropsychiatric symptoms (NPS) are increasingly recognized as a core element of Alzheimer's disease (AD); however, clinicians still consider AD primarily as a cognitive disorder. We describe a case in which the underrecognition of NPS as part of AD resulted in substantial delay of an AD diagnosis, a wrong psychiatric diagnosis, and the organization of inappropriate care. The aim of this paper is
