Calcium-activated chloride channel regulator 1 (CLCA1) belongs to a group of secreted self-cleaving proteins, which activate calcium-dependent chloride channels. CLCA1 has been shown to participate in the pathogenesis of inflammatory airway diseases such as asthma. Recently, additional functions of CLCA1 have been unveiled, including its metalloprotease property and involvement in mucus homeostasi

X-ray imaging using a Talbot-Lau interferometer, consisting of three binary gratings, is a well-established approach to acquire x-ray phase-contrast and dark-field images with a polychromatic source. However, challenges in the production of high aspect ratio gratings limit the construction of a compact setup for high x-ray energies. In this study we consider the use of phase gratings with triangul

BACKGROUND: The majority of out-of-hospital cardiac arrests (OHCAs) occur at place residence, which is associated with worse outcomes in unselected prehospital populations. Our aim was to investigate whether location of arrest was associated with outcome in a selected group of initial survivors admitted to intensive care.METHODS: This is a post-hoc analysis of the Targeted Temperature Management a

After crossing an initial barrier to break the first base-pair (bp) in double-stranded DNA, the disruption of further bps is characterized by free energies up to a few kBT. Thermal motion within the DNA double strand therefore causes the opening of intermittent single-stranded denaturation zones, the DNA bubbles. The unzipping and zipping dynamics of bps at the two zipper forks of a bubble, where

We use a master equation approach based on the Poland–Scheraga free energy for DNA denaturation to investigate the (un)zipping dynamics of a denaturation wedge in a stretch of DNA that is clamped at one end. In particular, we quantify the blinking dynamics of a fluorophore–quencher pair mounted within the denaturation wedge. We also study the behavioural changes in the presence of proteins that se

One of the most important theological questions in the first Origenist controversy was that of the resurrection of the dead. Jerome accused both Origen and contemporary “Origenists” of speaking only of the resurrection of the body, and not of the flesh, and he claimed that an idea of resurrection without the flesh could not guarantee the identity between the body living on earth and the resurrecte

Within cognitive science, narratives are regarded as crucial and fundamental cognitive instruments or tools. As Roger Schank suggests, the identity of (sub-)cultures is to a considerable extent based upon the sharing of narrative structures (Schank. 1995. Tell me a story: Narrative and intelligence. Evanston, IL: Northwestern University Press.). According to Schank, culturally shared stories, as d

Spectral oscillations in 2D molecular spectroscopy of the displaced oscillator system and their phase relationships are analyzed. The phase maps of the dispersive and absolute-valued signals give hints for experimental probing of peak oscillations.

The electromagnetic contribution to the K+-K0 mass difference is calculated in the 1 Nc approach including the SU(3) breaking contributions due to a non-zero strange quark mass. The short-distance contribution can be unambiguously determined in terms of the known parameters of the next-to-leading order chiral Lagrangian. The long distance part is estimated using the 1 Nc approach by Bardeen et al.

The renormalization of chiral perturbation theory is carried out to next-to-next-to-leading order in the meson sector. We calculate the divergent part of the generating functional of Green functions of quark currents to O(p6) for chiral SU(n), involving one- and two-loop diagrams. The renormalization group equations for the renormalized low-energy constants of O(p6) are derived. We compare our res

This study examines the interdependence between research and development (R&D) resources, coopetitive performance, and extent of cooperation in development-related standardization settings that involve network effects. Coopetitive performance is measured as the firm’s influence on the change process of standards. Cooperation is measured as the number of firm technology partners in influencing

Objective: To investigate the association between hospital volume and overall survival (OS), cancer-specific survival (CSS), and quality of care of patients with bladder cancer who undergo radical cystectomy (RC), defined as the use of extended lymphadenectomy (eLND), continent reconstruction, neoadjuvant chemotherapy (NAC), and treatment delay of 3 months after diagnosis. Conclusions: The current

Inflammatory myofibroblastic tumour (IMT) is a soft tissue tumour primarily affecting children and young adults. Approximately 50% of IMTs have gene fusions involving the receptor tyrosine kinase (RTK)-encoding ALK gene, providing a molecular rationale for treating IMT patients with unresectable tumours with tyrosine kinase inhibitors (TKI). However, a subset of IMT instead displays fusions affect

Chemical abundances for 15 elements (C, N, O, Na, Mg, Al, Si, K, Ca, Ti, V, Cr, Mn, Fe, and Ni) are presented for 83 stellar members of the 4 Gyr old solar-metallicity open cluster M67. The sample contains stars spanning a wide range of evolutionary phases, from G dwarfs to red clump stars. The abundances were derived from near-IR (λ1.5-1.7 μm) high-resolution spectra (R ,F= ,F22,500) from the SD