Aims/hypothesis: Some studies find an increased risk of type 1 diabetes in children exposed to antibiotics. We investigated if exposure to antibiotics increases the risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes. Methods: We used data from a Swedish case–control study (Epidemiological Study of Risk Factors for LADA and Type 2 Diabetes [ESTRID]: LADA, n=597; type 2 diabetes

Quasi-two dimensional (2D) perovskites have emerged as a promising class of materials due to their remarkable photoluminescence efficiency, which stems from their exceptionally high exciton binding energies. The spatial confinement of excitons within smaller grain sizes could enhance the formation of biexcitons leading to higher radiative recombination efficiency. However, the synthesis of high-qu

Climate warming is driving changes in species distribution, but habitat characteristics can interact with warming temperatures to affect populations in unexpected ways. We investigated wintering waterbird responses to climate warming depending on habitat characteristics, with a focus on the northern boundary of their non-breeding distributions where winter climatic conditions are more extreme. At

Included in 'Peter Sheppard Skærved’s Knowledge Exchange Violin'. A project that brings together historic instruments, composers, nature , painting, ecologists, architecture, and much more.

We aimed to investigate the genetic associations of neuropathic pain in a deeply phenotyped cohort. Participants with neuropathic pain were cases and compared with those exposed to injury or disease but without neuropathic pain as control subjects. Diabetic polyneuropathy was the most common aetiology of neuropathic pain. A standardised quantitative sensory testing protocol was used to categorize

The NMDA receptors are natural glutamate binders that play critical roles in the function of the central nervous system, with their dysfunction implicated in serious psychiatric disorders and neurodegenerative conditions. Understanding their roles in the brain and developing treatments will benefit from the existence of small molecules specifically targeting different NMDA receptor subtypes. This

Ground-level ozone (O3), formed via complex photochemistry involving nitrogen oxides (NOx) and volatile organic compounds (VOCs), is a critical secondary pollutant and oxidant. Therefore, understanding whether the formation of O3 is NOx- or VOC-limited is essential for effective air quality management. Recently, we demonstrated that the distribution of highly oxygenated organic molecules (HOMs) ca

This study delves into the landscape of health applications within online markets. These applications, offering health-related functionalities, have become integral to the lives of European citizens. The transformation of healthcare delivery, accelerated by the pace of modern life and accentuated by the COVID-19 pandemic, has elevated health applications from conveniences to essential tools capabl

The Rieger syndrome, an autosomal dominant disorder involving ocular, dental, and umbilical defects is caused bymutations in PITX2, a Bicoid type homeobox protein. Moreover, Pitx2 is involved in the Nodal/Sonic hedgehogpathway that determines left/right polarity. Mouse Pitx2 mRNA is expressed in eye, tooth and umbilicus consistent withthe human Riegers phenotype. It is also asymmetrically expresse

Rieger syndrome is an autosomal dominant human disorder affecting eye, tooth and umbilical development, andwhose primary morbidity is the 50% occurrence of glaucoma in affected individuals. The identification of etiologicmutations in the PITX2 gene and its encoded protein, solurshin, inspired the development of a transgenic animal thatmight serve as a model for this disorder. In addition, the more

The Axenfeld-Rieger syndrome is autosomal dominant and affects the development of eyes, teeth, and gut. The eyemanifestations include cloudy corneas, tearing, glaucoma, iris hypoplasia, irido-corneal adhesion, and occasionallymegalocornea. Mutations have been found in the genes for transcription factors PITX2 and FOXC1. Mice homozygousfor disruption of PITX2 are embryonic lethal from heart malform

Cesarean section (CS) is a life-saving procedure when performed for the right indication but carries substantial risks, specifically during subsequent pregnancies. The aim of this study was to evaluate obstetric outcomes for women 5 years after a CS performed by medical doctors and associate clinicians. This was a prospective multi-center observational study of women who had a CS at any of nine ho

Background and aimsSeveral studies have confirmed the presence of bacterial DNA in atherosclerotic plaques, but its contribution to plaque stability and vulnerability is unclear. In this study, we investigated whether the bacterial plaque-profile differed between patients that were asymptomatic or symptomatic and whether there were local differences in the microbial composition within the plaque.

The Bell-state measurement (BSM) is the projection of two qubits onto four orthogonal maximally entangled states. Here we first propose how to appropriately define more general BSMs, which have more than four possible outcomes, and then study whether they exist in quantum theory. We observe that nonprojective BSMs can be defined in a systematic way in terms of equiangular tight frames of maximally

Purpose: To develop a deep learning-based algorithm that automatically and accurately classifies patients as either having pulmonary emboli or not in CT pulmonary angiography (CTPA) examinations. Materials and methods: For model development, 700 CTPA examinations from 652 patients performed at a single institution were used, of which 149 examinations contained 1497 PE traced by radiologists. The n

Quantitative flow ratio (QFR) represents a physiological index derived from angiography through three-dimensional (3D) quantitative coronary analysis. When compared to coronary angiography, QFR showed better performance both for guiding percutaneous coronary intervention (PCI) in case of intermediate coronary lesions and for optimising PCI results. In addition, QFR showed good diagnostic agreement

A major development in international schools since the first decade of the 21st century is the growth of global firms operating revenue-oriented schools. Whereas international schools were once community organizations serving the needs of expatriate communities, the landscape has been transformed into an education industry. Transnational corporations and revenue-oriented nonprofits have acquired s

Shape-controlled precursors enable grain alignment without using an applied magnetic field in the permanent magnet material strontium hexaferrite. The effect is investigated by conducting four series of experiments using different compaction methods: two cold and two hot compactions. The hypothesis is that magnetic short-circuiting will diminish the grain alignment (texture) in cold compacted samp

Background and Non–HDL-C provides an estimate of lipid-associated risk and is a secondary treatment target after myocardial infarction Aims (MI). The aim was to study the relationship between non–HDL-C levels after MI and risk of adverse outcomes. Methods From the SWEDEHEART registry, 56 262 patients with MI were included. Outcomes were major adverse cardiovascular event (MACE: death, MI, and isch