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Recombinant adeno-associated viruses (AAVs) are popular in vivo gene transfer vehicles. However, vector doses needed to achieve therapeutic effect are high and some target tissues in the central nervous system remain difficult to transduce. Gene therapy trials using AAV for the treatment of neurological disorders have seldom led to demonstrated clinical efficacy. Important contributing factors are

Context: Both scientific publications and grey literature have widely been employed as sources of empirical evidence in evidence-based software engineering (EBSE). However, there is still a fierce debate about whether or not the pervasive Web content can act as an alternative means to gather evidence for EBSE. Aim: To help ourselves enter this debate, this work aims to obtain some pre-evidence of

A great deal of literature has analyzed the relationship between warfare and state capacity in late-modern and contemporary times. While there is a consensus regarding the significant impact of mass warfare on fiscal expansion during the twentieth century, the interplay between warfare and fiscal capacity in the nineteenth century remains disputed. This paper sheds light on this issue by making us

The flux during membrane filtration can be enhanced by the use of a two-phase gas–liquid flow. This has been shown to be an energy-efficient alternative to increasing the cross-flow velocity. In this work, air sparging was used to increase the flux during ultrafiltration of alkali-extracted wheat bran hemicelluloses. Batch filtration was performed in a pilot unit with a ceramic ultrafiltration mem

In order to increase the use of sustainable energy in Sweden, it is necessary to substitute fossil energy carriers with renewable counterparts. Synthetic natural gas (SNG) produced from renewable resources via biomass gasification and methanation could replace a proportion of the natural gas used in Sweden. In order to facilitate the implementation and expansion of SNG production and use in Sweden

This chapter discusses the Directive on Administrative Cooperation and the Recovery Directive.

This report summarizes unannounced evacuation experiments in a hotel building with evacuation elevators as one of the escape routes. The participants in the experiments were wearing an eye tracking device. The results of the experiments show that there is a high acceptance for using evacuation elevators as an escape route in the evaluated type of high-rise building. The results also show that most

This report summarizes evacuation experiments performed in a Virtual Reality environment. The experiments are performed in a subway station equipped with evacuation elevators. This study is the second step in the process of ensuring the function of new evacuation solutions. The purpose of the study is to investigate if the exit choice in the subway station can be affected by technical way-finding

A search for the exclusive decays of the Higgs and Z bosons to a ϕ or ρ meson and a photon is performed with a pp collision data sample corresponding to an integrated luminosity of up to 35.6 fb−1 collected at s=13 TeV with the ATLAS detector at the CERN Large Hadron Collider. These decays have been suggested as a probe of the Higgs boson couplings to light quarks. No significant excess of events

Inclusive J/ψ production is studied in p-Pb interactions at a centre-of-mass energy per nucleon-nucleon collision sNN=8.16 TeV, using the ALICE detector at the CERN LHC. The J/ψ meson is reconstructed, via its decay to a muon pair, in the centre-of-mass rapidity intervals 2.03 < ycms < 3.53 and −4.46 < ycms < −2.96, where positive and negative ycms refer to the p-going and Pb-going direction, resp

Measurements of anisotropic flow coefficients with two- and multi-particle cumulants for inclusive charged particles in Pb-Pb collisions at sNN=5.02 and 2.76 TeV are reported in the pseudorapidity range |η| < 0.8 and transverse momentum 0.2 < pT < 50 GeV/c. The full data sample collected by the ALICE detector in 2015 (2010), corresponding to an integrated luminosity of 12.7 (2.0) μb−1 in the centr

The European Spallation Source is designed to deliver 5 MW proton beam power on the target while keeping the beam induced losses below 1 W/m throughout the LINAC. This implies the need of accurate models to correctly describethe longitudinal beam dynamics within the multi-cell cavities. In all the previous error studies the cells of a multicell cavity were modelled as a sequence of independent gap

The particle longitudinal dynamics is affected by errors on the phase and amplitude of the electro-magnetic field in each cavity that cause emittance growth, beam degradation and losses. One of the causes of the phase error is the change of the ambience temperature in the LINAC tunnel, in the stub and in the klystron gallery that induces a phase drift of the signal travelling through the cables an

Quinoline-3-carboxamides (Q substances) are small molecule compounds with anti-inflammatory properties. In this study, we used one of these substances, Paquinimod, to treat a novel model for chronic liver inflammation and liver fibrosis, the NOD-Inflammation Fibrosis (N-IF) mouse. We show that treatment of N-IF mice significantly reduced inflammation and resulted in the regression of fibrosis, eve

Nanotechnology and engineered nanomaterials (ENM) empower existing technologies. One of the great examples are III-V semiconductor nanowires (NW), which have a broad application range. The occupational safety and hazard organizations draw attention to ENM, as their physical and chemical characteristics differ from the ones of bulk materials. Additionally, the NW high aspect ratio geometry is of gr