PURPOSE OF REVIEW: Immune thrombocytopenia (ITP) is a bleeding disorder in which both antibody and cell-mediated autoimmune responses are directed against an individual's own platelets and/or megakaryocytes, leading to either enhanced platelet destruction and/or reduced platelet production, respectively. The cause of this platelet-specific autoimmunity remains unknown, but there has been a constan

With regards to research animal models related to immune thrombocytopenia (ITP), there is an extensive literature of over 300 publications published since 1959. It appears that many of these models either confirm what has been found in human ITP or, in some instances, are the first to describe a phenomenon related to ITP that is still of relevance today in human medicine. These models will undoubt

Immune thrombocytopenia (ITP) is a bleeding disorder characterized by antibody-opsonized platelets being prematurely destroyed in the spleen, although some patients with ITP may have a cell-mediated form of thrombocytopenia. Although several animal models of ITP have been developed, few mimic primary chronic ITP nor have any shown cell-mediated platelet destruction. To create this type of model, s

A study of tonality and modality in contemporary dance music and the thoughts on aural training related to said genre.

Background Environmental barriers increase risk for mobility difficulties in old age. Mobility difficulty is preceded by a phase where people try to postpone a difficulty through mobility modification. We studied whether perceived environmental mobility barriers outdoors correlate with mobility modification and mobility difficulty, predict development of mobility difficulty over a two-year follow-

This text is an attempt to approach fundamental layers in the formation ofmusical meaning in learning processes where musicians work with musicfrom cultures other than their own. The point of departure is my personalexperience as a musician from two distinct perspectives:• my double roles as a teacher of the zither đàn tranh in the VietnamNational Academy of Music as well as in the Malmö Academy o

UNLABELLED: Staphylococcus aureus is a ubiquitous opportunistic human pathogen and a major health concern worldwide, causing a wide variety of diseases from mild skin infections to systemic disease. S. aureus is a major source of severe secondary bacterial pneumonia after influenza A virus infection, which causes widespread morbidity and mortality. While the phenomenon of secondary bacterial pneum

Companies are constantly being pressured to innovate in order to stay competitive in the short run and have new offerings in the long run. One way of boosting innovation is to develop idea support systems that go beyond the traditional methods and tools. Through a qualitative study, this paper explores the lessons learned from developing an online platform for idea generation, and discusses it in

In this paper the linearized equations of motion in multibody dynamics are derived. Explicit expressions for the coefficient matrices are presented and given their physical interpretations. The equations of motion are presented in terms of the mechanical stiffness, its adjoint and the associated differential operators. It is demonstrated how the adjoint matrix may be used to find solutions to the

Power electronics systems such as converters are increasingly being used to connect small scale power generation systems to distribution networks. One result of such converter systems is the introduction of harmonics into the distribution system. This paper develops a generic converter and converter controller model that allows the investigation of the effect of converter controlled systems on dis

Inom fysik försöker vi beskriva naturfenomen med matematiska modeller. Beroende på vilket system som ska beskrivas är olika modeller relevanta. På väldigt långa avstånd är gravitation den viktigaste kraften. Till exempel så beskrivs solsystemets dynamik av gravitation. På de kortaste avstånd som människan lyckats studera är det istället den elektromagnetiska, den svaga och den starka kraften som äIn this thesis we use effective field thory methods and models for low energy QCD in two different contexts. One is direct calculation of contributions to the anomalous magnetic moment of the muon, muon g-2. The other is estimates of systematic sources of uncertainty in lattice QCD simulations. The work is presented in five papers. Papers II, IV and V describe calculations for muon g-2 and papers

It is well-known that [S(x)]^n and [F(x)]^n are the survival function and the distribution function of the minimum and the maximum of n independent, identically distributed random variables, where S and F are their common survival and distribution functions, respectively. These two extreme order statistics play important role in countless applications, and are the central and well-studied objects

We propose a functional version of the Hodrick–Prescott filter for functional data which take values in an in nite-dimensional separable Hilbert space. We further characterize the associated optimal smooth- ing operator when the associated linear operator is compact and the underlying distribution of the data is Gaussian.

Photosensitization, an exaggerated sensitivity to harmless light, occurs genetically in rare diseases, such as porphyrias, and in photodynamic therapy where short-term toxicity is intended. A common feature is the experience of pain from bright light. In human subjects, skin exposure to 405 nm light induced moderate pain, which was intensified by pretreatment with aminolevulinic acid. In heterolog

The key steps in cellular signaling and regulatory pathways rely on reversible noncovalent protein-ligand binding, yet the equilibrium parameters for such events remain challenging to characterize and quantify in solution. Here, we demonstrate a microfluidic platform for the detection of protein-ligand interactions with an assay time on the second timescale and without the requirement for immobili

Background: Migraine and Cluster Headache (CH) are two primary headaches with severe disease burden. The disease expression and the mechanisms involved are poorly known. In some attacks of migraine and in most attacks of CH, there is a release of vasoactive intestinal peptide (VIP) originating from parasympathetic cranial ganglia such as the sphenopalatine ganglion (SPG). Patients suffering from t