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[4Fe–4S] clusters are essential cofactors in many proteins involved in biological redox-active processes. Density functional theory (DFT) methods are widely used to study these clusters. Previous investigations have indicated that there exist two local minima for these clusters in proteins. We perform a detailed study of these minima in five proteins and two oxidation states, using combined quantu

Den här boken behandlar offentlig upphandling från ett juridiskt och ett nationalekonomiskt perspektiv. Bokens disposition följer i princip upphandlingsprocessen, från behovsidentifiering till avtalsslut. Inledningsvis diskuteras när det är lämpligt att ersätta verksamhet i egen regi med upphandling. Därefter går boken in på hur offentlig upphandling ska genomföras, inom de ramar som ges av regelv

Background & aims: Despite advances in the management of short bowel syndrome related intestinal failure (SBS-IF), large-scale contemporary pediatric studies are scarce. The aim of this multicenter study was to assess key outcomes and clinical prognostic factors in a recent Nordic pediatric SBS-IF population. Methods: Patients with SBS-IF treated during 2010–2019, whose parenteral support (PS)

Ansvaret för att tillhandahålla välfärdstjänster i Sverige ligger i huvudsak på kommuner, landsting och regioner. Det gäller bland annat tillgång till bostäder, hälso- och sjukvård, avfallshantering och utbildning.Utförandet är dock ofta en uppgift för privata aktörer, vilket innebär att det EU-rättsliga regelverket aktualiseras. I den här rapporten diskuterar professor Tom Madell vilken betydelse

The use of municipally owned corporations (MOCs) has a long tradition in Sweden. In this chapter we take the point of departure in this long tradition of MOCs when describing how the use of these corporations has developed over time as well as the conditions under which these MOCs operate has developed. In addition, some of the more problematic features of MOCs, that Swedish local governments stru

Helminth/tuberculosis (TB)-coinfection can reduce cell-mediated immunity against Mycobacterium tuberculosis (Mtb) and increase disease severity, although the effects are highly helminth species dependent. Mtb have long been ranked as the number one single infectious agent claiming the most lives. The only licensed vaccine for TB (BCG) offers highly variable protection against TB, and almost no pro

Introduction We aimed to compare the proportions of patients with newly diagnosed psoriatic arthritis (PsA) and rheumatoid arthritis (RA) remaining on methotrexate (regardless of other disease-modifying antirheumatic drug (DMARD)-changes), and proportions not having started another DMARD (regardless of methotrexate discontinuation), within 2 years of starting methotrexate, as well as methotrexate

MAX IV Laboratory is a Swedish national synchrotron radiation facility that comprises three accelerators with varying characteristics. One of the accelerators, the 3 GeV storage ring, is the world’s first fourth-generation ring and pioneered the use of the multibend achromat lattice to provide access to ultrahigh brightness X-rays. MAX IV aims to stay at the forefront of the current and future res

Temperature is a major determinant of biological process rates, and microorganisms are key regulators of ecosystem carbon (C) dynamics. Temperature controls microbial rates of decomposition, and thus warming can stimulate C loss, creating positive feedback to climate change. If trait distributions that define temperature relationships of microbial communities can adapt to altered temperatures, the

Using electronic health records data and machine learning to guide future decisions needs to address challenges, including 1) long/short-term dependencies and 2) interactions between diseases and interventions. Bidirectional transformers have effectively addressed the first challenge. Here we tackled the latter challenge by masking one source (e.g., ICD10 codes) and training the transformer to pre

In this paper, we present a new framework for improving soil strength using an advanced method of engineering statistics. The materials included clay till collected in Yttre Ringvägen, southern Sweden. Binders included quicklime, slag and ordinary Portland cement used as pure binders and blended mixtures. We first applied the Response Surface Methodology techniques aimed at binder blend optimisati

The Mediterranean lizard Podarcis lilfordi is an emblematic species of the Balearic Islands. The extensive phenotypic diversity among extant isolated populations makes the species a great insular model system for eco-evolutionary studies, as well as a challenging target for conservation management plans. Here we report the first high-quality chromosome-level assembly and annotation of the P. lilfo

Increased scholarly interest in ideas, goods and people that crossed the boundaries between modern empires (c. 1850-1914), known as transimperial history, has directed attention to microhistorical cases of individuals with transimperial careers. Such life trajectories are interesting in themselves, but their representativeness and broader significance for modern imperial history is often unclear.

Cross-correlation spectroscopy is an invaluable tool in the study of exoplanets. However, aliasing between spectral lines makes it vulnerable to systematic biases. This work strives to constrain the aliases of the cross-correlation function to provide increased confidence in the detections of elements in the atmospheres of ultra-hot Jupiters (UHJs) observed with high-resolution spectrographs. We u

Ett konstnärligt och pedagogiskt utvecklingsarbete på tvären av två lektorer vid Musikhögskolan i Malmö. IN I MUSIKENS KOLORERADE UNIVERSVår ambition har varit att lyfta fram det experimentella och improvisatoriska i musiken utifrån en annan synvinkel än den traditionella - det vill säga att arbeta tvärkonstnärligt med färg, form, frekvenser och färglära. Utöver det, färgers och frekvensers påverk

We review the use of science by lawmakers and courts in implementing or rejecting legal rights for nature in Ecuador, India, the United States, and other jurisdictions where some type of rights of nature have been recognized in the legal system. We then use the “right to evolve” to exemplify how interdisciplinary work can (i) help courts effectively define what this right might entail; (ii) inform

In the vicinity of the type-I/type-II crossover in conventional superconductors, vortices exhibit a nonmonotonic interaction, which leads to exotic vortex matter states. We perform molecular dynamics simulations on a model superconductor in the intertype regime. In a field cooled approach, we examine the transition of a homogeneous vortex lattice (VL) into a structure consisting of VL domains and