The relationship between leukocyte migration and parenchymal cell death in vivo remains poorly documented. Accordingly, cell killing in the rat mesentery, as recorded by propidium iodide staining, was investigated with an intravital approach. Superfusion of platelet-activating factor (PAF, 10(-8) M) or N-formyl-methionyl-leucyl-phenylalanine (fMLP, 10(-8) M) led to extensive leukocyte extravasatio

A potentially important indirect effect of export processing zones (EPZs) is the catalyst effect. The foreign affiliates attracted to the EPZs could stimulate local firms to begin to export by showing them how to produce, market, sell and distribute manufactured goods on the world market. Our results indicate a significant catalyst effect in Malaysia.

The majority of aggressive forms of the childhood tumor neuroblastoma can with current treatment protocols not be cured and possess a major challenge in pediatric oncology. After initial rounds of chemotherapy, surgery and irradiation, which in most cases result in tumor regression, these aggressive neuroblastomas relapse and frequently develop drug resistance. As approximately 50% of the children

When an animal has to meet increased demands on its working capacity, for example, for thermoregulation or parental care, two strategies are available. The animal can reallocate energy from costly maintenance processes-such as immunological defence or DNA repair systems (compensation hypothesis)-or it may try to increase the rate of energy intake or efficiency of digestion by increasing the size o

The scientific community has gratefully embraced floating-point arithmetic to escape the close attention for accuracy and precision required in fixed-point computational styles. Though its deficiencies are well known, the role of the floating-point system as standard has kept other number representation systems from coming into practice. The paper discusses the relation between fixed and floating-

A new sampling method, termed negligible depletion hollow fiber-protected liquid-phase microextraction, was developed for sensing the freely dissolved concentration (C free) and evaluating the availability of atrazine (ATR), desethyl atrazine (DEA), and simazine (SIM) in water. The sampling device was prepared by impregnating 1-octanol to both the pores and the lumen of a piece of polypropylene mi

PURPOSE: To evaluate altered protein expression with tissue microarray methodology for 15 different markers with potential prognostic significance in invasive bladder cancer. MATERIALS AND METHODS: Invasive tumor was sampled with the tissue-arraying instrument in 133 consecutive patients who underwent radical cystectomy, and at least 3, 0.6-mm tissue cores were obtained. With immunohistochemistry,

A dream of many pharmaceutical companies is to be able to register a large design space with the regulatory agencies. The problem is that this will require both time and money, so an intelligent method of validating a design space is needed. The design space should only cover operating points at which the process runs optimally. This means that the process should be optimized for different process

An integrated nanoelectronic circuit is fabricated from a high-mobility In0.75Ga0.25As/InP heterostructure. The manufactured device comprises two double in-plane gate transistors with a current channel of 1.1 mu m in length and 100 nm in width. The two transistors are coupled to each other in a configuration that the source of one transistor is directly connected with one in-plane gate of the othe

We examine an effectively repulsive Bose-Einstein condensate of atoms that rotates in a quadratic-plus-quartic trapping potential. We investigate the phase diagram of the system as a function of the angular frequency of rotation and of the coupling constant, demonstrating that there are phase transitions between multiply and singly quantized vortex states. We also show that states of different cir

BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in women after menopause. In essence major risk factors for CVD are similar in women as for men inclusive of serum lipid perturbations. The effects of estrogens and hormone replacement therapy on lipid metabolism is widely discussed and warrant further evaluation especially when combined with other lipid lowering drugs. STUDY D

Exclusively synthesized by normal neutrophil and monocyte precursor cells, myeloperoxidase (MPO) functions not only in host defense by mediating efficient microbial killing but also can contribute to progressive tissue damage in chronic inflammatory states Such as atherosclerosis. The biosynthetic precursor, apoproMPO, is processed slowly in the ER, undergoing cotranslational N-glycosylation, tran

Possible consequences of the production of small black holes at the LHC for different scenarios with large extra dimensions are investigated. The effects from black hole production on some standard jet observables are examined, concentrating on the reduction of the QCD cross section. It is found that black hole production of partons interacting on a short enough distance indeed seem to generate a

The dic( 7; 9)( p11 similar to 13; p11 similar to 13) is a recurrent chromosomal abnormality in acute lymphoblastic leukemia (ALL), mainly of B-lineage. Although more than 20 dic(7; 9)-positive ALLs have been reported to date, the molecular genetic consequences of this aberration are unknown. We performed tiling resolution (32K) genome-wide array-based comparative genomic hybridization ( array CGH

Climate change and endeavours towards a sustainable society have brought the interest of wood-based biorefineries to the fore. Lignin is the main energy carrier in chemical pulp mills. Today, the heat value of lignin is commonly recovered in the recovery boiler of the mill. However, interest in the extraction of lignin for use as an external biofuel and in speciality chemicals is growing. Lignosul

Rheumatoid arthritis (RA) affects millions of people world wide causing considerable human suffering and large socioeconomic costs. Increased knowledge of pathological pathways involved in RA will enable development of modern drugs, with reduced side effects. The mouse models offer an attractive approach to dissect the genetic and molecular mechanisms of RA.

A density functional theory for polymer solutions is generalized to cases where the monomers have a different diameter to the solvent. An appropriate free energy functional is obtained by integration of the generalized Flory equation of state for such systems. This functional predicts that entropic demixing may occur in polymer solutions in which the solvent particles are smaller than the monomers