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The majority of breast cancers express estrogen receptor α (ERα), and most patients with ERα-positive breast cancer benefit from antiestrogen therapy. The ERα-modulator tamoxifen and ERα-downregulator fulvestrant are commonly employed antiestrogens. Antiestrogen resistance remains a clinical challenge, with few effective treatments available for patients with antiestrogen-resistant breast cancer.

Environmental exposures to endocrine disrupting chemicals have been suggested as a risk factor for male genital abnormalities such as hypospadias. The aim of this case-control study was to investigate the association between fetal exposure to persistent organochlorine pollutants (POP) and the risk for hypospadias.

AIM: The aim of this study was to investigate early changes in uptake of 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG) in vivo and in vitro in a squamous-cell carcinoma (SCC) cell line originating from a human head and neck SCC during cytotoxic therapy with respect to metabolism in tumor cells and in surrounding stromal tissue. MATERIALS AND METHODS: In 60 nude mice with xenografted SCC, 50 animals were

Objective: To locate components and target proteins of relevance for the cAMP and cGMP signaling networks including cAMP and cGMP phosphodiesterases (PDEs), salt-inducible kinases (SIKs), subunits of Na+, K+-ATPases, and aquaporins (AQPs) in the human saccule. Methods: The human saccule was dissected out during the removal of vestibular schwannoma via the translabyrinthine approach and immediately

Different short-term spectrum estimators for speaker verification under additive noise are considered. Conventionally, mel-frequency cepstral coefficients (MFCCs) are computed from discrete Fourier transform (DFT) spectra of windowed speech frames. Recently, linear prediction (LP) and its temporally weighted variants have been substituted as the spectrum analysis method in speech and speaker recog

Artikel om Jan Karski, polsk motståndsman som informerade polska och amerikanska politiker om förintelsen och som efter andra världskriget var verksam som statsvetare i USA.

MicroRNAs (miRNAs) are a novel class of small noncoding RNA molecules that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. There are more than 500 miRNA genes reported in the human genome, constituting one of the largest classes of regulatory genes. Increasing experimental evidence supports the idea of aberrant miRNA expression in cancer pathogenesis.

Non-governmental organizations (NGOs) are major players in development aid today. It is widely believed they represent civil society and that, for example, the UN and the World Bank would be strengtened if NGOs were given a larger influence over policy formulation and development. As one can hardly speak of an NGO community, the issue of representation is far from easily solved. NGOs often compete

Comparisons were made between two groups of households in a multi-family residential area in order to investigate how oral information through a door-stepping campaign can influence household food waste recycling behaviour from a quantitative as well as qualitative perspective. Source-separation behaviour was assessed both through weakly weighting of all source-separated food waste and dry recycla

Aims: It is well established that the main cause of the development of cardiovascular disease can be found in unhealthy lifestyle habits. In our study, we wanted to explore the long-term predictors of self-reported lifestyle changes in a middle-aged population after screening for cardiovascular risk factors 10 years earlier. Methods: We conducted a 10-year follow-up telephone interview on self-rep

In the US and most European countries, testicular cancer is the most common malignancy in young men aged 20-40 years. Since the introduction of cisplatin-based treatment in the 1970s, more than 95% of the patients are cured. The increasing incidence of testicular cancer and high survival rates, has led to a growing number of testicular cancer survivors (TCSs). As they have a long life expectancy i

We discuss some of the problems involved in homogenization of a composite material built from ferromagnetic inclusions in a nonmagnetic background material. The small signal permeability for a ferromagnetic spherical particle is combined with a homogenization formula to give an effective permeability for the composite material. The composite material inherits the gyrotropic structure and resonant

Anaerobic digestion (AD) of minimal nutrient-supplemented wheat straw and digestate liquor recycle was evaluated in semi-continuous processes using a novel BioReactor Simulator developed for easy accurate online normalised-gas measurement. Three scenarios (i) no recycle (NR), (ii) recycle of soluble nutrient (RSN), and (iii) recycle of nutrient and microbes (RNM) were investigated in order to eval

Popular Abstract in Swedish Sverige har i olika sammanhang beskrivits som ett land som präglas av så kallade mångkulturella sociala relationer. I avhandlingen I historiekanons skugga: Historieämnet och identifikationsformering i 2000-talets mångkulturella samhälle analyseras implikationer av framväxten av det så kallade mångkulturella samhället på historieämnet. Avhandlingens övergripande syfte ärSweden has on various occasions been described as a multicultural society. So-called multicultural social change has resulted in numerous implications regarding attitudes in respect of history as a subject taught at upper secondary schools. The aim of this study is to problematise the relationship between students' (ethnic) identification and their view of history as a subject. The study focuses o

The authors review the most important Spanish contributions to hypnosis during the 19th and 20th centuries, with emphasis on the work of Santiago Ramon y Cajal, winner of the 1906 Nobel Prize in medicine. It is widely accepted that he provided a basic foundation for modern neurosciences with his work on neuronal staining and synaptic transmission. What is missing in most accounts of his work is hi

Reduced transition strengths of the deexciting transitions from the first two excited states in 33Ar were measured in a relativistic Coulomb excitation experiment at the GSI Helmholtz center. The radioactive ion beam was produced by fragmentation of a primary 36Ar beam on a 9Be target followed by the selection of the reaction product of interest via the GSI Fragment Separator. The 33Ar beam hit a

End-to-side (ETS) nerve repair is used in selected clinical cases. The mechanisms, by which regeneration into the attached nerve segment is initiated and occur, are still not fully understood. Based on numerous experimental studies, different mechanisms have been Suggested by which regenerating axons are recruited, such as contamination From the proximal nerve segment, collateral sprouting, and te

The potential energy surfaces of the first excited triplet state of some ruthenium polypyridyl complexes were investigated by means of density functional theory. Focus was placed on the interaction between the geometrical changes accompanying the photoactivity of these complexes when used as antenna complexes in artificial photosynthesis and dye-sensitized solar cells and the accompanying changes

A major challenge for a person with diabetes is to adapt insulin dosage regimens and food intake to keep blood glucose within tolerable limits during daily life activities. The early knowledge about the effects of inputs on glycemia would provide the patients with invaluable information for appropriate on-the-spot decision making concerning the management of the disease. Against this background, i