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Integrerad analys av biologiska data från cancerceller och närliggande immunceller förbättrar möjligheten att utveckla nya behandlingar Teknikutveckling har nyligen möjliggjort att detaljerad data från enskilda celler i en tumör kan samlas in – detta kallas spatial/rumslig omik. Metoden gör det möjligt att kartlägga till exempel uttrycks nivåer av protein eller gener från specifika celler i en väThe rapid development of high-throughput technologies has made it possible to generate large-scale data such as genomics, transcriptomics, proteomics, and, more recently, spatial omics. A common approach is to analyse each data source individually (single-omics analysis). However, combining these sources of information (multi-omics integration) can create a complete picture of the biological mecha

Syftet med denna avhandling är att utveckla en ny metod för att producera bilder med syntetisk aperturradar (SAR), med utgångspunkt i scenarier med arbiträr rörelse vad gäller radarsensorn. SAR är en väletablerad metod för att skapa 2- eller 3-dimensionella radarbilder, som traditionellt sett antar att radar-sensorns rörelse är linjär och förutsägbar. Därmed är positionerna för varje radardata-punThe purpose of this thesis is to develop a novel approach to producing Synthetic Aperture Radar (SAR) images, assuming the scenario of arbitrary motion in regards to the radar sensor. SAR is a well-researched method for creating 2- or 3-dimensional radar images, traditionally assuming the radar sensor's motion to be linear and highly predictable. Thus the locations where each radar data is sam

Plastic pollution is one of the most severe forms of pollution and the high abundance of microplastics (MP) in aquatic ecosystems is already confirmed. Due to their small size and buoyancy, they are highly bioavailable and have been shown to have a wide range of negative impacts. As a result of their high trophic status and long lifespan, aquatic mammals are susceptible to bioaccumulation and biom

The striatum is the main input nucleus of the basal ganglia. Striatal subregions, which play different roles in motor functions, receive inputs from different cortical regions. Regulation of synaptic plasticity at the level of corticostriatal synapses is believed to underlie habit formation and motor learning. Alteration of plasticity at the level of corticostriatal synapses has been associated wi

Ökning i sydliga lövsångares flyttningsbeteende Fåglars flyttning har länge fascinerat människan och kanske framförallt småfåglars flyttning. Hur kan t. ex. en lövsångare, Phylloscopus trochilus, på 10 gram som föddes för några månader sedan hitta hela vägen ner till övervintringsområdena i Afrika, dessutom helt utan hjälp av andra? Sedan länge är det känt att svaret verkar ligga i deras gener mDifferences in migratory behaviour has long been suggested to potentially drive speciation, but the genetics underlying this process remains a mystery. Studies of hybrid zones between two closely related taxa with contrasting migratory phenotypes, called migratory divides, have played a crucial role for our understanding of how such differences can lead to reproductive isolation. Movements of hybr

TCP-25 Combination Therapy: Boosting the Effects of a Host Defense Peptide Wound infection is defined as the existence of pathogenic bacteria that multiply inside the wound and cause tissue or host damage. The process of wound repair is carried out in multiple steps. These steps restore tissue integrity and function in the majority of cases. Toll-like receptors (TLRs), which are essential for nor

The genome of the Belinda variety of the hexaploid oat (Avena sativa) has recently been sequenced and assembled. This project aims to improve the assembly by clustering the thousands of scaffolds into their three ancestral subgenomes using Principle Component Analysis (PCA) of kmer and repeat-element frequencies. The method was developed using a chromosome level assembly of hexaploid Wheat (Tritiu

Kan Bogong fjärilar dofta sig till en säker plats? Att komma hem från en lång semester och lägger sig i sin egen säng, känna doften av ens egna kudde och lägenhet ger en känsla av säkerhet. Det är en doft av hemma, av trygghet som vi känner igen. Är det möjligt att få samma upplevelse med en doft man aldrig känt förut? Så kan det vara för Bogong fjärilen (Agrotis infusa). De är nattaktiva fjärilaThe Bogong moth Agrotis infusa is a long-distance nocturnal migrant whose navigational ability still remains only partly understood. They travel up to a thousand kilometres to the Australian Alps where they seek out the shelter of isolated cool alpine caves, thereby escaping the approaching summer heat of their breeding grounds. Once in the caves, they enter a state of dormancy over the coming sum

The First Submarine Flotilla is expanding. Four submarines are to become five and a new, larger signal intelligence ship is to replace the current one. At the same time many employees are on the verge of retiring and new ones in need of training arrives. It is therefore of utmost importance that the existing staff want to remain in their workplace. The purpose of this study was, through a survey b

Civil conscription was a way to supply personnel for the civilian part of Swedish total defence. In 2010, the Swedish government chose to replace civil conscription with voluntary service. However in 2023, 13 years after the decision, it seems as reactivation is underway as the Swedish Civil Contingencies Agency (MSB) has been tasked to prepare for the activation of civil conscription for municipa

There is only one answer to why we did not have a referendum on applying for NATO membership. The changed security situation in Europe and the clearly changed threat against Sweden that has arisen from Russia's invasion of Ukraine have changed political views on Sweden's security. Sweden, which has been publicly neutral and non-aligned, is now choosing a clear side and requesting entry int

In recent years, both the price and the security of supply of plannable energy have changed drastically with increasing uncertainty regarding pricing and availability. The political will to ensure access to plannable and safe energy supply nationally has increased significantly during the same period. The study examines the question of whether the lack of cheap planable energy with the threat of e

According to the Swedish defense decision in 2020, the government decided to increase the military organization regarding the number of soldiers that can be put on active duty in case of war, from 60 000 to 90 000 men. The Swedish government came to a decision together with the help of two reports that the Swedish Defense Commission had written. In the decision, they wanted to reestablish a milita

In a recent survey made on behalf of The Swedish Civil Contingencies Agency it shows that 37 per cent of the Swedish population meet the governmental recommendations about civilian readiness during a societal emergency. In a different survey about interpersonal trust the results show that approximately 40 per cent of the people in Sweden do not feel high levels of trust towards others. This st

Divers from the Swedish Navy who specialize in explosive ordnance disposal are renowned for their professionalism and expertise. This study sheds light on the transformation that began at the start of the new millennium in an effort to become more adaptable and compatible with partners. The research was conducted through a qualitative study that comprised of directed open interviews. Multiple Stre

I have long been fascinated by the St. Pauli cemeteries in Malmö and how they relate to the city itself. A large residential area, Norra Sorgenfri, is currently being built around the cemeteries. As the city’s population density increases, more people use these cemeteries as their nearest green space. The work examines the possibilities for developing the use of St. Pauli cemeteries, as the city g

This paper investigates the efficacy of using various concentration strategies during musical performance in order to redirect the mind away from distracting thoughts and back to the present moment. I have recorded myself playing three different musical passages with four different mental focuses: physical sensations, technique, mental imagery, and internal singing. Throughout this research, I hav

The deep-sea may be on the verge of becoming the latest frontier for resource extraction of critical metals and minerals in order to build renewable energy technologies such as electric vehicles. This thesis examines the narratives used by the deep-sea mining company The Metals Company to justify the extraction of polymetallic nodules from the seabed in the Clarion Clipperton Zone in the Pacific O

This Bachelor’s thesis consists of an empirical study using a gravity regression model to determine if Ukrainian bilateral export flows were affected by the 2014 war through an increase in political and social risk functioning as trade resistance. There is an empirical research gap on this issue that this thesis attempts to mitigate. The study was conducted using PPML with fixed effects to solve t