Popular Abstract in English Huntingtons sjukdom (HS), även kallad danssjukan, är en ärftlig och dödlig sjukdom som leder till ofrivilliga motoriska rörelser. Personer med HS får vanligtvis symtom i medelål- dern och avlider efter 15–20 år. Diagnosen ställs klinisk när de första ofrivilliga rörelserna uppträder. Dessa symtom kan kopplas till celldöd i de delar av hjärna som styr vår rörelse. SjukdoHuntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of the CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances and metabolic dysfunction are also part of the disease manifestation. These symptoms often precede the motor symptoms by decades. The hypothalamus is an area in the brain involved in the regulation of emotions and m

PURPOSE. The authors recently showed that the retinal circulation can be accessed by transfemoral endovascular catheterization. The purpose of this study was to examine whether endovascular coiling can be used to induce different degrees of ischemic injury. The possibility of creating occlusions at different sites in the vasculature to cause retinal ischemia with different degrees of severity was

In the present work we show the capabilities of the new protocol called cryo-fracture TEM recently developed in our laboratory. The systems selected to test the protocol were C12E8-water and P84-water, and the phases imaged were lamellar (L-alpha), hexagonal (H-1) and cubic (I-1). This protocol is a natural extension of the capabilities of conventional cryo-TEM, which enables direct imaging of vis

The aim of the present study is to explore interpersonal dimensions of the presence of older patients at team meetings. The theoretical foundation of the study is grounded in caring science and lifeworld phenomenology. The results from two empirical studies, that indicated the need for a more in-depth examination of the interpersonal relationships when an older patient is present at a team meeting

A population-based observational study investigated the contribution of obstetric factors to the survival and postnatal development of extremely preterm infants.

The paper argues that policy-oriented educational research, specifically large-scale quantitative research, has produced a new kind of knowledge, which is herein termed third order knowledge. This expect knowledge distinquishes itself from tacit knowledge, everyday knowledge and social science knowledge through its purposes and sources. Third order knowledge is defined as knowledge of and for expe

Most studies of the relation between psychological performance in the elderly and deficiencies of cobalamin and folate have used methods that determine the blood concentrations of these vitamins, which might not reflect the vitamin status in the tissues. Recently, two new markers, plasma homocysteine and methylmalonic acid, have attracted growing interest since they are considered to reflect the s

The influence of aerosols, both natural and anthropogenic, remains a major area of uncertainty when predicting the properties and behaviour of clouds and their influence on climate. In an attempt to better understand warm cloud formation in a tropical marine environment, a period of intensive measurements took place in December 2004 in Puerto Rico, using some of the latest developments in online i

Hydrolysis of cellulose by Trichoderma cellulases often results in a mixture of glucose, cellobiose, and low-mol-wt cellodextrins. Cellobiose is nonfermentable for most yeasts, and therefore it has to be hydrolyzed to glucose by beta-glucosidase prior to ethanol fermentation. In the present study, the beta-glucosidase production of one Penicillium and three Aspergillus strains, which were previous

This paper discusses current Swedish international development policies on gender and violence. It deals with the relationship between development policies, global health, promotion of gender equality, and violence against women in a global perspective. The focus is on intimate partner violence and the highly promoted gender mainstreaming policy. Theoretically, our point of departure lies within a

The specific insertion of a divalent metal ion into tetrapyrrole macrocycles is catalyzed by a group of enzymes called chelatases. Distortion of the tetrapyrrole has been proposed to be an important component of the mechanism of metallation. We present the structures of two different inhibitor complexes: (1) N-methylmesoporphyrin (N-MeMP) with the His183Ala variant of Bacillus subtilis ferrochelat

Objective. The prevalence of anemia in inflammatory bowel disease (IBD) has been broadly described. The recurrence, type and burden of anemia remain unenlightened. The primary objective was to describe this. The secondary objective was to evaluate the implementation of European guidelines. Materials and methods. This longitudinal follow-up study included 300 IBD outpatients from six centers in Sca

Presumed effects of global warming on occupational heat stress aggravate conditions in many parts of the world, in particular in developing countries. In order to assess and evaluate conditions, heat stress must be described and measured correctly.

Study design:Register study.Objectives:To design and implement a validation process to check the completeness of the Hospital Discharge Register (HDR) held by the Swedish National Board of Health and Welfare.Setting:Sweden.Methods:An accurate traumatic spinal cord injury prevalence group (n=495) was acquired from the Swedish Spinalis Clinic. A register control was performed on the group by raising

It appears to be relatively common to assume that negative apparent chargeability data in time-domain induced polarisation (IP) surveying is a sign of bad data quality. Negative IP data can however occur as a consequence of the distribution of chargeable zones in the ground, which is well documented in literature. A general mechanism behind negative IP data is proposed as follows; if the chargeabl

OBJECTIVE: Our aim was to investigate exposure to polybrominated diphenyl ethers (PBDEs) in a young urban population in a developing country, with focus on potentially highly exposed children working informally as scrap scavengers at a large municipal waste disposal site. We also set out to investigate whether hydroxylated metabolites, which not hitherto have been found retained in humans, could b

We consider the problem of constructing linear precoders for quasi-stationary multiple-input multiple-output channels. Maximum-likelihood detection is assumed and the objective of the precoding is to maximize the minimum Euclidean distance of the signaling. Since the channel remains constant for some time, the precoding is performed spatially as well as across time. As will be shown, the precoder