Search results

Background: Rare disease clinical trials are notorious for complexities that frequently result in study-start delays. However, there is limited knowledge about how participants and researchers perceive these delays and what factors shape their experiences. A clinical trial in the rare, progressive disorder Pantothenate Kinase-Associated Neurodegeneration—the PKAN trial—encountered an unexpected de

Homelessness has increased significantly in Sweden since the early 1990s. A national survey of homelessness in 2023 showed that 27,383 people were in one of the four homelessness situations that are used in Sweden, namely 1) Acute homelessness, 2) Institutional and supported housing, 3) Long-term housing organised by the municipality and 4) Short-term accommodation arranged on one’s own. These homHomelessness has increased significantly in Sweden since the early 1990s. A national surveyof homelessness in 2023 showed that 27,383 people were in one of the four homelessnesssituations that are recognised in Sweden, namely: (a) acute homelessness; (b) institutional orsupported housing; (c) long-term housing organised by a municipality; and (d) short-termaccommodation arranged by people themselv

Background: Autoantibodies against β-cell components in the pancreatic islets of Langerhans are characteristic of type 1 diabetes (T1D). The genetic and autoimmune determinants of type 1 diabetes (T1D) in Ethiopians are not yet thoroughly characterized, with studies indicating a lower occurrence of autoantibodies related to T1D compared to Caucasians. The study aimed to determine the occurrence of

Background: The study aimed to analyze thyroid-stimulating hormone (TSH) levels quantitatively and investigate their potential correlation with the risk of incident atrial fibrillation (AF) in differentiated thyroid cancer (DTC) patients. Methods: DTC cases diagnosed between 1995 and 2015 in Stockholm, Sweden, were identified from the Swedish Cancer Registry. Medical records were scrutinized, and

Relational memory retrieval entails a dynamic interplay between eye movements and neural activity, yet the temporal coordination of these processes remains unclear. We examined how theta- and alpha-band EEG activity relates to sequential fixations during relational memory retrieval. Participants performed a two-alternative forced-choice associative memory task while eye movements and EEG were reco

A major target of the Marxist critique of “post-theory”—a broad term encompassing post-structuralism, post-Marxism, and postcolonial theory—has been its notorious deconstruction of the subject. The affirmation of marginal, excluded, and deviant subject positions within the same corpus has been noted less frequently. To recalibrate the Marxist critique of post-theory to also encompass its affirmati

Real-time 3D reconstruction is crucial for immersive AR/VR but is hard to achieve with traditional photogrammetry and mesh-based pipelines due to latency and limited scalability. Neural Radiance Fields (NeRF) enable high-quality novel view synthesis but suffer from long training and slow rendering, while Gaussian Splatting (GS) achieves real-time rendering at the cost of heavy preprocessing and me

Få aspekter av våra liv bidrar lika mycket till vår identitet och som källa till men- ing som arbetet. Samtidigt är behovet av mänsklig arbetskraft för att tillfredsställa grundläggande mänskliga behov mindre än någonsin, en tendens som kan komma att accelereras ytterligare de närmaste årtiondena till följd av ny teknologi. I mitt examensarbete försöker jag ta mig an frågan vad arbete egentligen äFew aspects of our lives contribute as much to our identity and sense of meaning as work. At the same time, the need for human labour to satisfy basic human needs is lower than ever—a trend that may accelerate further in the coming decades due to new technologies. In my thesis, I attempt to explore the question of what work actually is, the role it plays in our lives and in society, how it has bee

Energy transfer within various LH2 antenna complexes of the photosynthetic purple bacteria Rhodobacter sphaeroides and Rhodopseudomonas acidophila has been studied at 77 K using tunable femtosecond and subpicosecond infrared pulses. The complexes examined include the wild-type B800-850 as well as three different specifically mutated complexes. The site-directed mutant strains were altered at posit

Energy transfer within the peripheral light-harvesting antenna of the purple bacteria Rhodobacter sphaeroides and Rhodopseudomonas palustris was studied by one- and two-color pump-probe absorption spectroscopy with approximately 100-fs tunable pulses at room temperature and at 77 K. The energy transfer from B800 to B850 occurs with a time constant of 0.7 +/- 0.05 ps at room temperature and 1.8 +/-

Great progress in the study of structure and dynamics of photosynthetic light-harvesting pigment-protein complexes has recently resulted in detailed understanding of the light-harvesting and light-conversion processes of photosynthesis. We review and discuss recent results on the elementary excitation transfer dynamics of the purple bacterial LH2 peripheral complex. When combining the information

Triple-negative breast cancer (TNBC) accounts for 10-20% of primary breast cancers and often has early relapses and aggressive progression. An activated tumour immune response can be prognostic in treatment-naive and chemotherapy-treated TNBC patients and may be assessed using gene expression data. We derived a stand-alone predictor for a proposed immunomodulatory transcriptional TNBC subtype in a

Biomarkers for evaluating response to neoadjuvant chemotherapy (NACT) in ER+/HER2- breast cancer remain limited. This study explores the impact of NACT on tumor proliferation dynamics and its association with relapse-free interval (RFI) among 175 patients with early ER+/HER2- breast tumors. Proliferation was assessed at baseline, after completing two NACT cycles, and in the residual tumor using Ki

This essay examines whether ontological vagueness can coherently resolve Peter Unger’s "The Problem of the Many" — the dilemma that ordinary objects like clouds or stones must either not exist or exist in overwhelming multiplicity due to their indeterminate boundaries. While Unger rejects vague objects as incoherent, attributing vagueness instead to semantic imprecision, this essay defen

Aim: The aim of this paper is to examine how Baby Boomers perceive fashion brands sustainability and what that implies for brands marketing strategy. Since Baby Boomers are the second largest generation and most research has been targeting the younger generation, although the baby boomer generation has a higher economic power. Approach: We conducted a qualitative study using eight interviews with

Purpose: In recent years, professional sports have become increasingly globalized and commercialized. This is reflected in the increased strategic application of branding across teams, athletes and other stakeholders in the sports industry to differentiate themselves, secure sponsorships, and enhance fan engagement. As athletes increasingly recognize the value of their personal brands, understandi

Bakgrund: Allt fler personer vårdas i det egna hemmet trots avancerad sjukdom och med avancerad medicinsk behandling. Den mer avancerade vården sågs tidigare som den typ av vård som gavs inneliggande på sjukhus. Patienters hem utgör distriktssköterskors arbetsplats. Ibland behöver ambulans tillkallas och då ska distriktssköterskor och ambulanssköterskor samverka med varandra kring äldre patienter.

Antibiotics are crucial in treating infectious diseases, particularly in intensive care unit patients, but they can lead to side effects such as ototoxicity. A mechanism for this is antibiotics targeting mitochondrial components in eucaryotic cells, due to their resemblance of those in bacteria. Here we investigate how five classes of antibiotics (carbapenems, fluoroquinolones, aminoglycosides, gl