Background and Objectives: Blood services manage the increasingly tight balance between the supply and demand of blood products, and their role in health research is expanding. This review explores the themes that may define the future of blood banking. Materials and Methods: We reviewed the PubMed database for articles on emerging/new blood-derived products and the utilization of blood donors in

Recent years have seen the emergence of critical studies pro-duced by third- generation Displaced Persons (hereafter DPs),questioning ethno-nationalist historical narrations, hegemonicin the community. Yet, in the Ukrainian diaspora in Canada, suchstudies have been absent. Kassandra Luciuk’s current study iswritten by someone raised in the political elite of the Ukrainianethno-nationalist communit

Poly-ADP-ribose polymerases (PARPs) catalyze transfer of ADP-ribose from NAD(+) to specific residues in their substrate proteins or to growing ADP-ribose chains. PARP activity is involved in processes such as chromatin remodeling, transcription control, and DNA repair. Inhibitors of PARP activity may be useful in cancer therapy. PARP2 is the family member that is most similar to PARP1, and the two

Paraplegin is an m-AAA protease of the mitochondrial inner membrane that is linked to hereditary spastic paraplegias. The gene encodes an FtsH-homology protease domain in tandem with an AAA+ homology ATPase domain. The protein is believed to form a hexamer that uses ATPase-driven conformational changes in its AAA-domain to deliver substrate peptides to its protease domain. We present the crystal s

Lake level, area and volume are sensitive indicators of climate change. At present, many studies have focused on the interannual water balance of lakes, but lake level and area can change remarkably with seasons, especially for lakes with seasonal ice cover. Zhari Namco, a seasonal frozen lake, was selected as an example to investigate its seasonal water balance. Multi-source altimetry and Landsat

Biological invasions pose a global challenge, affecting ecosystems worldwide and human societies. Knowledge of the evolutionary history of invasive species is critical to understanding their current invasion success and projecting their future spread. However, to date, few studies have addressed the evolutionary history and potential future spread of invaders simultaneously. In this study, we expl

Aim: To explore the impact of age on the discriminative ability of the National Early Warning Score (NEWS) 2 in prediction of unanticipated Intensive Care Unit (ICU) admission, in-hospital cardiac arrest (IHCA) and mortality within 24 hours of Rapid Response Team (RRT) review. Furthermore, to investigate 30- and 90-day mortality, and the discriminative ability of NEWS 2 in prediction of long-term

Objective Elite para athletes report a high incidence of sports injuries. Research suggests that athletes’ strategies to manage adversities may influence the sports injury risk, but knowledge about para athletes’ coping behaviours and their association with injuries is limited. The aim was to describe the distribution of coping behaviours in Swedish elite para athletes by sex, age, impairment, spo

Human calcitonin (hCT) is an endogenous polypeptide commonly employed in treating bone resorption-related illnesses, but its clinical application is limited due to its high aggregation tendency. Metalloporphyrins are effective in suppressing amyloid fibrillation, positioning them as potential drug candidates for amyloidogenic disorders like Alzheimer's and type 2 diabetes. In this work, we investi

Brain ischemia is a major cause of neurological dysfunction and mortality worldwide. It occurs not only acutely, such as in acute ischemic stroke (AIS), but also in chronic conditions like cerebral small vessel disease (cSVD). Any other conditions resulting in brain hypoperfusion can also lead to ischemia. Ischemic events can cause blood-brain barrier (BBB) disruption and, ultimately, white matter

We evaluate a place-based policy aimed at commercial service providers. In 2016, the Swedish government introduced special operating support for grocery stores in remote rural areas to slow down the process of store closures. We estimate the local causal effect in a regression discontinuity design framework using the fact that only stores located at least 15 km away from another store were eligibl

Software analytics (SA) is frequently proposed as a tool to support practitioners in software engineering (SE) tasks. We have observed that several secondary studies on SA have been published. Some of these studies have overlapping aims and some have even been published in the same calendar year. This presents an opportunity to analyze the congruence or divergence of the conclusions in these studi

Pseudo-Random Injections (PRIs) have been used in several applications in symmetric-key cryptography, such as in the idealization of Authenticated Encryption with Associated Data (AEAD) schemes, building robust AEAD, and, recently, in converting a committing AEAD scheme into a succinctly committing AEAD scheme. In Crypto 2024, Bellare and Hoang showed that if an AEAD scheme is already committing,