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Aquaporin-0 (AQP0) is the main water channel in the mammalian lens and is involved in accommodation and maintaining lens transparency. AQP0 binds the Ca2+-sensing protein calmodulin (CaM) and this interaction is believed to gate its water permeability by closing the water-conducting pore. Here, we express recombinant and functional human AQP0 in Pichia pastoris and investigate how phosphorylation
Background: In image processing for activity quantification, the end goal is to produce a metric that is independent of the measurement geometry. Photon attenuation needs to be accounted for and can be accomplished utilizing spectral information, avoiding the need of additional image acquisitions. The aim of this work is to investigate the feasibility of 177Lu activity quantification with a small
Ribbed channel flows are encountered in numerous engineering applications to promote turbulence and enhance heat transfer in various cooling passages, e.g., in turbine blades and at combustor walls. Numerical simulations have become an increasingly useful tool for studying the behavior of fluids in rib-roughened channels to provide insights into the complex turbulence structures and flow separatio
Of concern is the fractional Kadomtsev–Petviashvili (fKP) equation and its lump solution. As in the classical Kadomtsev–Petviashvili equation, the fKP equation comes in two versions: fKP-I (strong surface tension case) and fKP-II (weak surface tension case). We prove the existence of nontrivial lump solutions for the fKP-I equation in the energy subcritical case α>45 by means of variational method
Characterization of emissions from fires in a laboratory-controlled environment are presented in this report. The project is initiated by the CERN HSE Unit and is called FIRIA, Fire-Induced Radiological Integrated Assessment. The objective of FIRIA is to enhance the knowledge of aerosols emitted from fires in order to develop dispersion models of radiologically-activated material in case of fire.
Context: For nonazoospermic infertile men with elevated sperm DNA fragmentation (SDF), it is unclear whether the use of testicular sperm for intracytoplasmic sperm injection (ICSI) may offer advantages over ejaculated sperm. Objective: To determine whether ICSI outcomes (fertilisation rate, pregnancy rate, miscarriage rate, and live birth rate) are better with testicular sperm than with ejaculated
Imagination is a human capacity that reproduces and transforms experiences and thoughts. The capacity is manifested in children's pretend play and is an important part of adults' ability to process the past, and to plan the future. A first step in the development of imagination is the ability to represent objects and events and to change these representations into alternatives to reality. For adap
Performance of a proton exchange membrane (PEM) fuel cell is very sensitive to its electric resistance appearing in its functional components. In this paper, the electric resistance as well as related parameters of a cell is evaluated by a recently developed numerical method in the through-plane direction of the electrodes. The results show that the channel/rib structure leads to non-homogeneous e
When the assembly force is applied, the gas diffusion layer (GDL) deformation is observed and the geometry and transport parameters are also changed. Accordingly, the transport processes and cell performance are affected due to the deformation effect. In the present study, a three-dimensional, non-isothermal, two-phase flow model was developed and applied to investigate the effect of GDL deformati
One way to facilitate electrochemical communication between bacterial cells and electrodes is the use of artificial redox mediators. There are, however, a number of drawbacks when they are used in their freely diffusing monomeric form. In contrast when bound to flexible polymeric backbones they not only serve as mediators but also as an immobilization matrix forming a 3D hydrogel on the electrode
Perovskite-silicon tandem solar cells are a promising concept for overcoming the limits of conventional silicon single-junction technology. Light management is doubtless a key issue for further boosting efficiency. We discuss the impact of photonic nanostructures on the optical performance of perovskite-silicon devices. We experimentally and numerically demonstrate shallow antireflective nanotextu
Employer branding in organizational human resources management is essential. Nevertheless, certain gaps persist within the realm of scientific research in this field, particularly in the exploration of novel concepts like employer brand personality appeal and its potential impact within the hospitality industry, which grapples with numerous human resources challenges. To fill this gap in knowledge
With an aging population, an increased burden is put on national and regional healthcare and social systems. In Sweden, municipalities are required to provide inhabitants with the social services needed to enable them to live an independent life in their own home for as long as possible. Urban green spaces (UGS) may increase physical activity and social interaction, as well as improve wellbeing an
Objectives: To explore the association between antibiotic combination therapy and in-hospital mortality in patients with septic shock in two tertiary ICUs in different countries. Design: Retrospective observational study. Setting: ICUs of two tertiary hospitals, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia, and Rigshospitalet, Copenhagen, Denmark. Patients: Adult patients with ant
Background: Chronic rhinosinusitis (CRS) disease control is a global metric of disease status for CRS. While there is broad acceptance that it is an important treatment goal, there has been inconsistency in the criteria used to define CRS control. The objective of this study was to identify and develop consensus around essential criteria for assessment of CRS disease control. Methods: Modified Del
Human factors (HF) is a cross-disciplinary field of science that is strongly associated with safety, especially in regards to the role of human performance in ensuring safe actions and outcomes. Although ‘cross-disciplinary' in this context represents the admirable aim to use all available knowledge to enhance safety, even the field of human factors has to outline the limitations of itself as a fi
The term “mission” in its modern meaning was coined during the expansion of Western Christianity which was in many ways entangled with colonialism. The Western missionary movement’s modus operandi was adopted by missions from other backgrounds as well, when economic growth and growth of revivalist Christianity have coincided. When the outcome is new churches in economically underprivileged areas,
