Objectives: Decision-analytic models assessing the value of emerging Alzheimer's disease (AD) treatments are challenged by limited evidence on short-term trial outcomes and uncertainty in extrapolating long-term patient-relevant outcomes. To improve understanding and foster transparency and credibility in modeling methods, we cross-compared AD decision models in a hypothetical context of disease-m

This study aimed to explore the effect of dietary magnesium intake on breast cancer risk both directly and indirectly via its effect on inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6). This case-control study recruited 1050 case patients and 1229 control subjects. Inflammatory marker levels of 322 cases and 322 controls, randomly selected, were measured using ELISA, and data

Copper is an essential micronutrient and yet is highly toxic to cells at elevated concentrations. P1B-ATPase proteins are critical for this regulation, providing active extrusion across cellular membranes. One unique molecular adaptation of P1B-ATPases compared to other P-type ATPases is the presence of metal-binding domains (MBDs) at the cytosolic termini, which however are poorly characterized w

A carbohydrate-rich diet results in hyperglycaemia and hyperinsulinaemia; it may further induce the carcinogenesis of colorectal cancer. However, epidemiological evidence among Chinese population is quite limited. The aim of this study was to investigate total carbohydrate, non-fibre carbohydrate, total fibre, starch, dietary glycaemic index (GI) and glycaemic load (GL) in relation to colorectal c

The effects of dietary vitamin D, Ca and dairy products intakes on colorectal cancer risk remain controversial. The present study investigated the association between these dietary intakes and the risk of colorectal cancer in Guangdong, China. From July 2010 to December 2018, 2380 patients with colorectal cancer and 2389 sex- and age-matched controls were recruited. Dietary intake data were collec

Anti-tumor effect of dietary flavonoids has been sustained by laboratory experiments, but epidemiological studies with breast cancer risk remained inconsistent and insufficient. This study aimed to investigate the associations between total and subclasses of flavonoid and breast cancer risk among Chinese population. This case-control study recruited 1522 eligible breast cancer cases and 1547 frequ

This chapter contextualizes and discusses the Buddhist approach taken by Ranil Wickremesinghe (born 1949), a prominent political figure who has served as Prime Minister of Sri Lanka on six occasions and who held the office of the ninth President until September 2024. It analyses Wickremesinghe’s political career and his ability to navigate the complex interplay between Sinhalese Buddhist ethno-rel

....men inte heller ett neutralt verktyg för offentlig förvaltning. Via en teknikhistorisk återblick diskuterar Stefan Larsson och Ellinor Blom Lussi aspekter av hur ny teknik, här med fokus på AI, påverkar individer, professioner och organisationer. Med denna introducerande artikel till temat digitalisering pekar de dels på några av de väldigt löftesrika tekniktrender som är kopplade till automat

Zinc and selenium may protect against colorectal cancer (CRC) progression through their anti-oxidative effects. This study examined the independent and combined effect of dietary zinc and selenium intake, and polymorphisms of the oxidative stress-related genes (superoxide dismutase 1, superoxide dismutase 2, glutathione peroxidase, and catalase) on CRC risk in a Chinese case-control study. A total

OBJECTIVE: Glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR) is expressed on CD4(+) effector memory T cells and regulatory T cells; however, its role on these functionally opposing cell types in atherosclerosis is not fully understood.APPROACH AND RESULTS: Low-density lipoprotein receptor-deficient mice (Ldlr(-/-)) were lethally irradiated and reconstituted with e

BACKGROUND AND AIMS: Atherosclerosis is a lipid-driven chronic inflammatory disorder of the arteries, and monocytes and macrophages play a central role in this process. Within the atherosclerotic lesion, macrophages can scavenge modified lipids and become the so-called foam cells. We previously reported that the epigenetic enzyme Kdm6b (also known as Jmjd3) controls the pro-fibrotic transcriptiona

Social workers strive to provide the best support to each client, making it crucial to consider not just group-level effects of interventions but also individual outcomes. While empirical evidence often stems from group-based analyses, these offer limited insights into individual change, which is key for tailoring interventions. The aim of this study is to highlight the importance of individual-le

Introduction: During recent years, the world—including Scandinavia—has experienced significant challenges with shortages of antibiotics. In Scandinavia, phenoxymethylpenicillin is recommended as first-line antibiotic treatment for most acute respiratory tract infections (ARTIs). However, the Scandinavian countries each constitute rather small markets for phenoxymethylpenicillin. The aim of this di

У цій статті досліджено професійний підхід до ілюстрування книг для дітей та підлітків. Також визначено значення розвитку фантазії, образного мислення, виховання смаку та введення у світ сучасного мистецтва. Описано принципи оформлення та ілюстрування книг з урахуванням вікових особливостей сприйняття дітей, а також важливість привабливості ілюстрацій для зацікавлення маленьких читачів. РозглянутоThe purpose of the study is to investigate the possibilities of replacing the introductory version of MATLAB in educational disciplines related to digital image processing with an open and free analogue of GNU Octave. Using the example of laboratory tasks for the educational discipline "Digital Image Processing", similar capabilities, functionality and syntax of both software packages have been ex

У цій статті досліджено професійний підхід до ілюстрування книг для дітей та підлітків. Також визначено начення розвитку фантазії, образного мислення, виховання смаку та введення у світ сучасного мистецтва. писано принципи оформлення та ілюстрування книг з урахуванням вікових особливостей сприйняття дітей, а також важливість привабливості ілюстрацій для зацікавлення маленьких читачів. Розглянуто Based on the minimum angular size of the image, which is limited by the resolution of the human visual analyzer, a formula was derived for calculating the diagonal of the screen of the information display device. For two levels of unmanned aircraft systems – operational and tactical – the parameters of video monitors were obtained, which allow improving the image contrast, facilitating the operato

This open access handbook aims to constitute a reference point on political norm dynamics in Southeast Asia, by bringing together the array of normative repertoires that frame the possibilities for citizens to participate in, set agendas for, make decisions in, and contest, not only electoral and institutional politics but also informal and imaginary political spaces. It sheds light on intersectin