C4b-binding protein rescues beta-cells from islet amyloid polypeptide induced cytotoxicity
Type 2 diabetes is characterized by hyperglycemia and insulin resistance, which leads to increased production of insulin. Together with insulin the hormone peptide islet amyloid polypeptide (IAPP) is secreted, which is thought to be the cause of beta-cell death in later stages of type 2 diabetes. C4b-binding protein (C4BP) has been shown to upregulate IAPP fibrillation, which would lead to more ma
