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The immune cell component of the tumor microenvironment is an important modulator of tumor progression. In patients with breast cancer, tumor-infiltrating lymphocytes (TILs) and tertiary lymphoid structures (TLS) represent core aspects of anti-tumor immunity, both increasingly recognized for clinical relevance. In this study, we evaluated immune-related histology features using whole slide H&E
Mounting climate-related floods, fires, droughts and storms across the globe raise crucial questions about the role of law in adjudicating rights and obligations. While climate litigation attracts scholarly attention, vulnerable populations often lack the means to use formal laws and courts. We draw on ethnographic interviews conducted in 2022 in the city of Cartagena, Colombia, to study how resid
Group A Streptococcus (GAS)causes infections ranging from mild sore throats to severe invasive disease; however, no licensed vaccine is currently available. In this thesis, the author leverages streptolysin O (SLO), an important GAS protein and therapeutic/vaccine target, as a model system to develop a multimodal protein mass spectrometry(MS) strategy. Through an integrated approach of MS-based pr
This chapter explores the interaction between competition law and especially Article 101(3) TFEU and environmental and climate change goals in the context of the EU’s Green Deal and the aim of energy transition. First, it reviews the evolution of the Commission’s and national authorities’ approaches to environmental and climate benefits in their general assessment of horizontal and vertical agreem
Ne Zha has successfully created both an emotional and patriotic bond with Chinese audiences while boosting China's cultural confidence.
We reconcile dense and sparse modelling by exploiting the positive aspects of both. We employ a high-dimensional, approximate static factor model and assume the idiosyncratic term follows a sparse vector autoregressive model (VAR). The estimation is articulated in two steps: (i) factors and loadings are estimated via principal component analysis (PCA); (ii) a sparse VAR is estimated via the lasso
Our food and land-use systems are critical for staying within our planetary boundaries and the Earth’s system resilience. Among the six Transformations required to achieve the Sustainable Development Goals (SDGs), the fourth Transformation—focusing on food, land, and water—is crucial. This Transformation is key to achieving SDG 2 (Zero Hunger), SDG 6 (Clean Water and Sanitation), SDG 12 (Responsib
Research question: Do directed oocyte donors differ from non-directed identity-release oocyte donors regarding pre-donation motives and ambivalence, and post-donation satisfaction and openness? Design: The study is part of the longitudinal Swedish Study on Gamete Donation where consecutive samples of identity-release gamete donors at seven Swedish University Hospitals were approached during a 3-ye
Regardless of our socio-juridical position in or outside of organisations, this much is certain: even if not formally employed, we all, Agamben’s Homo Sacer series and the bulk of his other texts imply, are subject to a violence that, if differentially, imprisons us in a world in which ‘work’ reigns supreme. But what precisely is ‘work’? And is there, in spite of our securing the necessities of liRegardless of our socio-juridical position in or outside of organisations, this much is certain: even if not formally employed, we all, Agamben’s Homo Sacer series and the bulk of his other texts imply, are subject to a violence that, if differentially, imprisons us in a world in which ‘work’ reigns supreme. But what precisely is ‘work’? And is there, in spite of our securing the necessities of li
Gamma-aminobutyric acid (GABA) is known for its multiple physiological functions, including beneficial effects against several metabolic disorders. This study explores enzymatic strategies to enhance the functional value of Andean seeds, specifically tarwi (Lupinus mutabilis), cañihua (Chenopodium pallidicaule) and quinoa (Chenopodium quinoa) real varieties, by converting their naturally occurring
PURPOSE: Four-pool Voigt (FPV) machine learning (ML)-based fitting for Z-spectra was developed to reduce fitting times for clinical feasibility in terms of on-scanner analysis and to promote larger cohort studies. The approach was compared to four-pool Lorentzian (FPL)-ML-based modeling to empirically verify the advantage of Voigt models for Z-spectra.METHODS: Voigt and Lorentzian models were fitt
Nature-based solutions, such as urban green spaces, are shown to contribute to carbon emissions reduction and carbon sequestration, and also to have valuable indirect effects and behavioural impacts. Implementing such solutions could achieve carbon neutrality within the decade in several major cities in Europe.
Adapting successes of policy transition from one city to another has been more difficult than single case of successful sustainability-driven projects and developments. A thorough understanding of local biophysical and socio-economic conditions is essential in formulating effective development plans and policies. Here, we propose the use of a social-ecological model as a comparative tool to help u
Climate change poses a threat to cities. Geospatial information and communication technology (Geo-ICT) assisted planning is increasingly being utilised to foster urban sustainability and adaptability to climate change. To fill the theoretical and practical gaps of urban adaptive planning and Geo-ICT implementation, this article presents an urban ecosystem vulnerability assessment approach using in
In the context of accelerated urbanization, socioeconomic development, and population growth, as well as the rapid advancement of information and communication technology (ICT), urban land is rapidly expanding worldwide. Unplanned urban growth has led to the low utilization efficiency of land resources. Also, ecological and agricultural lands are continuously sacrificed for urban construction, whi
