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Short term exposure to low amounts of airway irritants in a swine confinement building and inflammatory markers in blood and exhaled air.

Introduction and objective. Swine confinement buildings are known to contain large concentrations of airway irritants, and a number of studies have shown acute inflammatory effects in previously unexposed subjects when introduced to the environment in such buildings. However, studies comparing different methods of assessing such reactions are lacking, and it is not known if a measurable response c

Aiming for emmetropia after cataract surgery: Swedish National Cataract Register study

PURPOSE: To assess and analyze refractive outcome after cataract surgery in Sweden from 2008 though 2010. SETTING: Swedish cataract surgery units participating in outcome registration of National Cataract Register. DESIGN: Cohort study. METHODS: Planned and actual postoperative refractions were analyzed for cataract procedures and preoperative and postoperative corneal astigmatism for procedures p

Evolution of complex symbiotic relationships in a morphologically derived family of lichen-forming fungi.

We studied the evolutionary history of the Parmeliaceae (Lecanoromycetes, Ascomycota), one of the largest families of lichen-forming fungi with complex and variable morphologies, also including several lichenicolous fungi. We assembled a six-locus data set including nuclear, mitochondrial and low-copy protein-coding genes from 293 operational taxonomic units (OTUs). The lichenicolous lifestyle ori

Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery.

The bioactivity of neuropeptide Y (NPY) is either N-terminally modulated with respect to receptor-selectivity by dipeptidyl-peptidase 4 (DP4)-like enzymes or proteolytic degraded by neprilysin or meprins, thereby abrogating signal transduction. However, neither the subcellular nor the compartmental differentiation of these regulatory mechanisms is fully understood. Using mass spectrometry, selecti

Integrated Modeling of a Laboratory Setup for a Large Deformable Mirror

We study a concept for a low-cost, large deformable mirror for an Extremely Large Telescope. The use of inexpensive voice-coil actuators leads to a poorly damped faceplate, with many modes within the desired control bandwidth. A control architecture, including rate and position feedback to add damping and stiffness, for the faceplate has been presented in our previous papers. An innovative local c

Saccharomyces cerevisiae: a potential host for carboxylic acid production from lignocellulosic feedstock?

Carboxylic acids are important bulk chemicals that can be used as building blocks for the production of polymers, as acidulants, preservatives and flavour compound or as precursors for the synthesis of pharmaceuticals. Today, their production mainly takes place through catalytic processing of petroleum-based precursors. An appealing alternative would be to produce these compounds from renewable re

Ni-Cu ion exchange observed for Ni(II)-porphyrins on Cu(111)

A Ni-Cu ion exchange has been observed for (5,15-dibromo-10,20-diphenylporphyrinato)nickel(II) (NiDBrDPP) and (5,10,15,20-tetrakis-(4-bromophenyl) porphyrinato)nickel(II) (NiTBrPP) on Cu(111). The ion exchange proceeds at a faster rate for the NiDBrDPP/Cu(111) system compared to NiTBrPP/Cu(111). This is explained in terms of the macrocycle-substrate distance and the distortions

The effect of heat treatment of thylakoids on their ability to inhibit in vitro lipase/co-lipase activity.

Thylakoids has been shown to prolong lipolysis by the inhibition of lipase/co-lipase, which makes thylakoids suitable as a functional food ingredient with satiating properties. The components of thylakoids that provide its function as a lipolysis modulator are primarily photosystems I and II, which are structurally stabilised by chlorophyll. However, chlorophyll is known to be heat sensitive yet t

Computer aided warfarin dosing in the Swedish national quality registry AuriculA - Algorithmic suggestions are performing better than manually changed doses

Introduction: Warfarin treatment with a high time in therapeutic range (TTR) is correlated to fewer complications. The TTR in Sweden is generally high but varies partly depending on local expertise and traditions. A dosing algorithm could minimize variations and increase treatment quality. Here we evaluate the performance of a computerized dosing algorithm. Materials and methods: 53.779 warfarin t

P-Wave Morphology Is Unaffected by Atrial Size: A Study in Healthy Athletes.

Orthogonal P-wave morphology has previously been described in different populations, but its relation to atrial size has not been studied in detail. In this study, we investigated whether atrial size affects P-wave morphology in athletes, who are known to have different degrees of atrial enlargement.

Parasite infestation and predation in Darwin's small ground finch: contrasting two elevational habitats between islands

Contrasting ecological conditions may affect the distribution, abundance and impact of parasites and predators throughout the ranges of hosts and prey. Such patterns are evident on the archipelagos of Hawaii and the Galapagos, which vary in their distribution and abundance of avian parasites within and across islands. Previous research has documented higher intensity of parasitic fly larvae (Philo

An inventory model with unidirectional lateral transshipments

This paper deals with a continuous review inventory system with Poisson demand, in which lateral transshipments are allowed. In case of a shortage at a location, another location acts as a supplier, if it is possible. A common assumption in earlier papers is that transshipments are allowed between all locations. This network configuration may, however, not be the best choice for many reasons. one

Limiting the parameter space in the Carbon Cycle Data Assimilation System (CCDAS)

Terrestrial ecosystem models are employed to calculate the sources and sinks of carbon dioxide between land and atmosphere. These models may be heavily parameterised. Where reliable estimates are unavailable for a parameter, it remains highly uncertain; uncertainty of parameters can substantially contribute to overall model output uncertainty. This paper builds on the work of the terrestrial Carbo

Effect of celecoxib on survival in patients with advanced non-small cell lung cancer: A double blind randomised clinical phase III trial (CYCLUS study) by the Swedish Lung Cancer Study Group

Background: Increased expression of cyclooxygenase-2 (COX-2) is common in non-small cell lung cancer (NSCLC) and has been associated with poor prognosis. Experimental and clinical phase II trials have indicated that the addition of the COX-2 inhibitor celecoxib to palliative chemotherapy might increase survival time in patients with advanced NSCLC. Methods: We performed a double-blind, placebo-con

Increased long-term mortality with plasma transfusion after coronary artery bypass surgery.

PURPOSE: Patients undergoing cardiac surgery often require transfusions of red blood cells, plasma and platelets. These components differ widely in both indications for use and composition. However, from a statistical point of view there is a significant colinearity between the components. This study explores the relation between the transfusion of different blood components and long-term mortalit