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Primary astrocytomas of grade 3 or 4 according to the classification system of the World Health Organization (high-grade astrocytomas or HGAs) are preponderant among adults and are almost invariably fatal despite the use of multimodal therapy. Here we show that the juvenile brain has an endogenous defense mechanism against HGAs. Neural precursor cells (NPCs) migrate to HGAs, reduce glioma expansio
Background: Saccharification and fermentation of pretreated lignocellulosic materials, such as spruce, should be performed at high solids contents in order to reduce the cost of the produced bioethanol. However, this has been shown to result in reduced ethanol yields or a complete lack of ethanol production. Previous studies have shown inconsistent results when prehydrolysis is performed at a high
Recent years have seen increasing interest in indirect genetic effects, i.e. influences on the phenotype that depend on the genotype of other conspecific individuals; however, the empirical evidence for such effects is still limited, especially in wild plant species. The present study of the clonal herb Sedum album assessed direct and indirect genetic effects on performance-related traits in a 4-y
Background: Ten to 30% of HIV-1 infected subjects develop broadly neutralizing antibodies (bNAbs) during chronic infection. We hypothesized that immunizing rabbits with viral envelope glycoproteins (Envs) from these patients may induce bNAbs, when formulated as a trimeric protein and in the presence of an adjuvant. Methods: Based on in vitro neutralizing activity in serum, patients with bNAbs were
P>Regional transplant practices may affect clinical outcomes within multinational studies. This study evaluated whether the overall results from the Symphony study can be generalized to the participating countries. De novo adult renal transplant recipients (n = 1645) were randomized to receive standard-dose cyclosporine, or daclizumab induction plus low-dose cyclosporine, low-dose tacrolimus, or l
Besides bone marrow, the kidneys are often dose-limiting organs in internal radiotherapy. The effects of high-linear energy transfer (LET) radiation on the kidneys after alpha-radioimmunotherapy (alpha-RIT) with the alpha-particle emitter, At-211, were studied in nude mice by serial measurements of the glomerular filtration rate (GFR). The renal toxicity was evaluated at levels close to the dose l
In Study 1 (N= 203) the factor structure of a Swedish translation of Pacini and Epstein's Rational-Experiential Inventory (REI-40) was investigated using confirmatory factor analysis. The hypothesized model with rationality and experientiality as orthogonal factors had satisfactory fit to the data, significantly better than alternative models (with two correlated factors or a single factor). Inclu
Background: Abdominal wounding by traumatic insemination and the lack of a long distance attraction pheromone set the scene for unusual sexual signalling systems. Male bed bugs (Cimex lectularius) mount any large, newly fed individual in an attempt to mate. Last instar nymphs overlap in size with mature females, which make them a potential target for interested males. However, nymphs lack the fema
The Siljan impact structure is the largest known impact structure in Europe, the result of a Late Devonian meteorite impact (380.9 +/- 4.6 Ma). It is outlined mainly by a ring of lakes and Palaeozoic sedimentary rocks of Ordovician to Devonian age. The Palaeozoic successions are generally poorly exposed, but often well preserved with clear stratigraphy. At some locations they are strongly tectonis
The standardization of work processes is a common feature of the public administration, aiming at both efficiency and equal treatment of citizens. Combining this standardization with employee motivation is considered a challenge. This challenge is explored, based on a survey to 261 social insurance officers (SIOs) at the Swedish Social Insurance Agency. Results reveal that, contrary to expectation
The interest in the evaluation of health effects due to EMF has accelerated in the last decades, mostly motivated by the occupational and environmental exposures to humans by such non-ionizing fields. The increasing exposure to electromagnetic fields has been suspected to contribute to the rising incidence of cancer in industrialized countries Despite detailed analysis which provide a wealth of ac
Non-melanoma skin cancer (NMSC), comprising of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), is the most prevalent cancer amongst Caucasians. The main risk factor for the development of NMSC is UV-irradiation but human papillo-mavirus (HPV) might be a co-factor. We extended the heterogeneity of the genus Betapapillomavirus by characterizing six putative types, HPV93 (species 1), 96
Epigenetic events have emerged as key mechanisms in the regulation of critical biological processes and in the development of a wide variety of human malignancies, including gastric cancer (GC), however precise gene targets of aberrant DNA methylation in GC remain largely unknown. Here, we have combined pyrosequencing-based quantitative analysis of DNA methylation in 98 GC cases and 64 controls ne
One problem in concentrating photovoltaic systems without active cooling is the formation of hot spots on the solar module cells. These hotspots are a result of uneven concentration of radiation within the solar module cells. The overall effect of concentrated heating is the reduction in the fill-factor of the solar module cell and the subsequent decrease in the overall efficiency of the system. I
Multifunctional buildings are characterized by multiple functions located within the same building. In this report specific problem areas are identified by the means of interviews and previous method development. The risks identified consider multifunctionality and antagonistic attacks. As a result from the previous method developed and the interviews, reference scenarios are suggested and conclus
Popular Abstract in Swedish För att förstå tillväxten av den kontinentala jordskorpan är det nödvändigt att kunna uppskatta balansen mellan juvenilt bidrag från manteln, infra-krustal omarbetning av jordskorpa och transport av krustalt material tillbaka till manteln. Sedan början av seklet har användandet av in situ U–Pb, Lu–Hf och O-isotop analyser av mineralet zirkon som ett verktyg för att adreTo understand the growth of continental crust, the balance between juvenile mantle derived extraction, infracrustal reworking and crustal recycling, needs to be estimated. Since the beginning of the century, the use of coupled in situ zircon U–Pb, Lu–Hf and O isotope analyses as a tool to address these questions have increased exponentially. Numerous compilations of ever growing datasets have been
Suppressor of cytokine signaling 2 (SOCS2) is known as a feedback inhibitor of cytokine signaling and is highly expressed in primary bone marrow (BM) cells from patients with chronic myeloid leukemia (CML). However, it has not been established whether SOCS2 is involved in CML, caused by the BCR/ABL1 fusion gene, or important for normal hematopoietic stem cell (HSC) function. In this study, we demo
Airway epithelial injury is regarded as a key contributing factor to the pathogenesis of exercise-induced bronchoconstriction (EIB) in athletes. The concentration of the pneumoprotein club cell (Clara cell) CC16 in urine has been found to be a non-invasive marker for hyperpnoea-induced airway epithelial perturbation. Exercise-hyperpnoea induces mechanical, thermal and osmotic stress to the airways
