BACKGROUND AND AIM: Warming temperature promotes bacterial growth while extreme precipitation enhances fecal-oral route of exposures to these pathogens, particularly in resource limited settings, increasing burden of diarrheal diseases. Given climate change related increases in frequency of extreme events, there is a pressing need to develop meaningful early warning system with adequate lead time

BACKGROUND: ATOR-1017 (evunzekibart) is a human agonistic immunoglobulin G4 antibody targeting the costimulatory receptor 4-1BB (CD137). ATOR-1017 activates T cells and natural killer cells in the tumor environment, leading to immune-mediated tumor cell death.METHODS: In this first-in-human, multicenter, phase I study, ATOR-1017 was administered intravenously every 21 days as a monotherapy to pati

CD40-stimulating immunotherapy can elicit potent anti-tumor responses by activating dendritic cells and enhancing T-cell priming. Tumor vessels orchestrate T-cell recruitment during immune response, but the effect of CD40-stimulating immunotherapy on tumor endothelial cells has not been evaluated. Here, we have investigated how tumor endothelial cells transcriptionally respond to CD40-stimulating

Agonistic CD40 antibodies activate dendritic cells and can expand and activate tumor-specific T cells. Our purpose was to assess the CD40 agonistic antibody ADC-1013 in the clinical setting including intratumoral administration since preclinical studies have indicated that intratumoral is better than intravenous administration. A Phase I, open label, multicenter study was conducted in patients wit

Background: The CTLA-4 blocking antibody ipilimumab has demonstrated substantial and durable effects in patients with melanoma. While CTLA-4 therapy, both as monotherapy and in combination with PD-1 targeting therapies, has great potential in many indications, the toxicities of the current treatment regimens may limit their use. Thus, there is a medical need for new CTLA-4 targeting therapies wit

Uppslagsord: mellankrigstiden i Nationalencyklopedin.

Uppslagsord: Waffen-SS i Nationalencyklopedin

Uppslagsord under "Historia", historia som skolämne i Nationalencyklopedin.

Uppslagsord: Lima i Nationalencyklopedin.

Uppslagsord: Raoul Wallenberg i Nationalencyklopedin.

Uppslagsord: Berlinkonferensen i Nationalencyklopedin.

Uppslagsord: Raphael Lemkin i Nationalencyklopedin.

Uppslagsord: historiebruk i Nationalencyklopedin.

Background: The Swedish housing stock generally maintains a high standard. However, earlier policies prioritized quantity and rapid housing production targeting a younger population, over policies that require accessible housing design. With an aging population, evidence-based policies supporting ageing in place while managing societal costs are crucial. This thesis aimed to increase the knowledge

The vast potential of using sediment adsorbed DNA as a window to past and present biodiversity rely on the ability of solid surfaces to adsorb environmental DNA. However, a comprehensive insight into DNA adsorption at surfaces in general is lacking. Soot and charcoal are carbonaceous materials widespread in the environment where they read-ily can come in contact with extracellular DNA shed from or