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How accurate are continuum solvation models for drug-like molecules?
We have estimated the hydration free energy for 20 neutral drug-like molecules, as well as for three series of 6-11 inhibitors to avidin, factor Xa, and galectin-3 with four different continuum solvent approaches (the polarised continuum method the Langevin dipole method, the finite-difference solution of the Poisson equation, and the generalised Born method), and several variants of each, giving
Art in Oceania: A new history
Scaling of the mean and variance of population dynamics under fluctuating regimes
Theoretical ecologists have long sought to understand how the persistence of populations depends on the interactions between exogenous (biotic and abiotic) and endogenous (e.g., demographic and genetic) drivers of population dynamics. Recent work focuses on the autocorrelation structure of environmental perturbations and its effects on the persistence of populations. Accurate estimation of extinct
Oak leaves as aerosol collectors: relationships with wind velocity and particle size distribution. Experimental results and their implications
Advancing the understanding of the aerosol-capture efficiencies of forest components such as leaves and needles, and of the mechanisms that underpin these efficiencies, is essential to the many related issues of forest turnover of nutrients and pollutants. For idealized collectors (such as artificial plates or cylinders) aerosol-mechanics offers a means for calculating capture efficiencies. For li
An approach to constraint-based and mass-customizable product design
In traditional product development, several iterations are usually necessary to obtain a successful compromise between constraints emanating from engineering, manufacturing, and aesthetics. Moreover, this approach to product development is not well suited for true mass-customization, as the manufacturing company remains in control of all aspects of the shape of the product-to-be. In this article,
Investigation and optimisation of mobile Nal(Tl) and He-3-based neutron detectors for finding point sources
Neutron radiation produces high-energy gamma radiation through (n,gamma) reactions in matter. This can be used to detect neutron sources indirectly using gamma spectrometers. The sensitivity of a gamma spectrometer to neutrons can be amplified by surrounding it with polyvinyl chloride (PVC). The hydrogen in the PVC acts as a moderator and the chlorine emits prompt gammas when a neutron is captured
Innovationsdrivande forskning i praktiken. Samverkan mellan forskare och praktiker för att skapa organisatoriska innovationer
Images of the EU in EPA negotiations: Angel, demon - or just human?
A striking feature of the discourses surrounding the negotiations of Economic Partnership Agreements between the EU and developing states is the starkly contrasting pictures given of the role and nature of the EU. The Union is either portrayed as an angel, an actor with altruistic objectives, concerned primarily with the economic and social development of the ACP countries, or as a demon, an actor
Effects of Water Stress, Organic Amendment and Mycorrhizal Inoculation on Soil Microbial Community Structure and Activity During the Establishment of Two Heavy Metal-Tolerant Native Plant Species
Our aim was to examine the effect of water stress on plant growth and development of two native plant species (Tetraclinis articulata and Crithmum maritimum) and on microbial community composition and activity in the rhizosphere soil, following the addition of an organic amendment, namely sugar beet residue (SBR), and/or the inoculation with an arbuscular mycorrhizal (AM) fungus, namely Glomus mos
A TX VCO for WCDMA/EDGE in 90 nm RF CMOS
A VCO is implemented in an RF 90 nm CMOS process and covers the frequency range 2.55-4.08 GHz. Drawing 19 mA from 1.2 V, the phase noise at 20 MHz frequency offset from a 3.7 GHz carrier is -156 dBc/Hz, meeting the phase noise requirement for GSM/EDGE and SAW-less WCDMA transmitter after frequency division by 2 or by 4. A second version of the VCO covers an additional 4.90-5.75 GHz range, at the e
Diagnosis and progression of sacroiliitis in repeated sacroiliac joint computed tomography.
Objective. To assess the clinical utility of repeat sacroiliac joint computed tomography (CT) in sacroiliitis by assessing the proportion of patients changing from normal to pathologic at CT and to which degree there is progression of established sacroiliitis at repeat CT. Methods. In a retrospective analysis of 334 patients (median age 34 years) with symptoms suggestive of inflammatory back pain,
C-reactive protein, immunoglobulin G and complement co-localize in renal immune deposits of proliferative lupus nephritis
The pattern recognition molecules C-reactive protein (CRP) and C1q are of big interest in relation to the pathogenesis of systemic lupus erythematosus (SLE). Circulating autoantibodies against CRP and C1q are frequently found in SLE patients with active disease, particularly in lupus nephritis (LN), and rising levels reportedly relate to disease activity and outcome. If CRP-, or dsDNA- and/or C1q-
A new model for CO₂-absorption of concrete structures. CO₂-cycle in cement and concrete Part 7: Models for CO₂-absorption.
After further laboratory and field studies we have now used the previous and new findings to create a model for CO₂-absorption of concrete structures. Some knowledge is still missing and some results are still not fully understood. In those cases we have done our best to base the model on reasonable assumptions, from what could be expected from some new literature that has been studied.
Swedish Prime Ministers in 100 years
Metabolite profiles and the risk of developing diabetes
Emerging technologies allow the high-throughput profiling of metabolic status from a blood specimen (metabolomics). We investigated whether metabolite profiles could predict the development of diabetes. Among 2,422 normoglycemic individuals followed for 12 years, 201 developed diabetes. Amino acids, amines and other polar metabolites were profiled in baseline specimens by liquid chromatography-tan
David John Galloway 1942-2014, a life with lichens
A Secular Utopia : Remarks on the Löwith-Blumenberg Debate
The article discusses the philosophical debate between Karl Löwith and Hans Blumenberg. Contrary to figures such as Landauer and Buber – but also to a number of other figures discussed in this volume – these two thinkers were united in their hesitance about the purportedly constructive impact of the biblical theological legacy on modern political thought. Significant to both philosophers, in spite
Treatment of spontaneous osteonecrosis of the knee (SPONK) by a bisphosphonate A prospective case series with 17 patients
Background and purpose Primary spontaneous osteonecrosis of the knee is a painful lesion in the elderly without any known cause. The onset of pain is usually acute. The prognosis is poor with high frequency of osteoarthritis, joint surface collapse, and subsequent knee surgery. In the present study, we determined whether bisphosphonates can prevent the joint surface collapse by delaying the post-n
Care planning at home: a way to increase the influence of older people?
Abstract in UndeterminedIntroduction: Care-planning meetings represent a common method of needs assessment and decision-making practices in elderly care. Older people's influence is an important and required aspect of these practices. This study's objective was to describe and analyse older people's influence on care-planning meetings at home and in hospital. Methods: Ten care-planning meetings we