Aims: Pleural mesothelioma (PM) is a highly aggressive thoracic tumour with poor prognosis. Although reduced tissue drug accumulation is one of the key features of platinum (Pt) resistance, little is known about Pt distribution in human PM. Methods: We assessed Pt levels of blood samples and surgically resected specimens from 25 PM patients who had received neoadjuvant Pt-based chemotherapy (CHT).

Operando X-ray studies of chemical reactions have gained increasing interest lately, fueled by the emergence of a new generation of powerful focused X-ray sources. Although it is well known that ionizing radiation causes damage to samples via radical chemistry, this effect is often overlooked in studies of working devices or catalysts where intense focused beams are used as nanoscale probes. Here,

The work focuses on analysis and development of integrated low-pressure shaft generator in a geared twin-spool turbofan engine. It starts with manufacturing and evaluation of direct cooled hollow conductor coils, and has focus manufacturing, assembling and integration issues essential to machine design. The experiment-in-loop, but the model-based evaluation focuses not only on the coolant and cool

Electromagnetic induction (EMI) methods are often used to map rapidly large areas with minimal logistical efforts. However, they are limited by a small number of frequencies and by their severe ill-posedness. On the other hand, electrical resistivity tomography (ERT) results are generally considered more reliable, with no need for specific calibration procedures and easy 2D/3D inversion. Still, ER

Streamflow estimation is important in hydrology, especially in drought and flood-prone areas. Accurate estimation of streamflow values is crucial for the sustainable management of water resources, the development of early warning systems for disasters, and for various applications such as irrigation, hydropower production, dam sizing, and siltation management. This study developed the ANN algorith

HIV-2 infection will progress to AIDS in most patients without treatment, albeit at approximately half the rate of HIV-1 infection. HIV-2 capsid (p26) amino acid polymorphisms are associated with lower viral loads and enhanced processing of T cell epitopes, which may lead to protective Gag-specific T cell responses common in slower progressors. Lower virus evolutionary rates, and positive selectio

Cities have an important role to play in implementing the UN Sustainable Development Goals (SDGs) and to mobilize sustainability at the urban level. Yet, municipalities encounter challenges in localizing the SDGs into their governance structures, and there is a need to advance our understanding of cities strengths and weaknesses in such processes. In this article we provide knowledge and reflectio

This chapter presents a synthesis of the entire edited collection. In doing so, three key themes are developed which emerged from the chapter contributions. These themes are as follows: planning for climate change, second home community responses to climate change, and second home impacts on climate change. These themes are elaborated in the context of the relevant supporting chapters before the a

Whole-genome duplication has shaped the evolution of angiosperms and other organisms, and is important for many crops. Structural reorganization of chromosomes and repatterning of gene expression are frequently observed in allopolyploids, with physiological and ecological consequences. Recurrent origins from different parental populations are widespread among polyploids, resulting in an array of l

It has been a mystery that the detected fluorescence intensity of single MEH-PPV molecules is much lower than expected based on their chain length. In this review, after re-evaluating of the literature data in the light of new specially designed experiments, we present a comprehensive explanation of this issue: The actual size of MEH-PPV molecules at single molecule level is much smaller than expe

Aggregated insoluble tau is one of two defining features of Alzheimer’s disease. Because clinical symptoms are strongly correlated with tau aggregates, drug development and clinical diagnosis need cost-effective and accessible specific fluid biomarkers of tau aggregates; however, recent studies suggest that the fluid biomarkers currently available cannot specifically track tau aggregates. We show

BACKGROUND: Both COVID-19 and its associated societal restrictions have affected individuals' health and everyday life. In Sweden, more lenient public health restrictions were implemented, with individuals asked to act responsibly in terms of reducing spread of disease. The majority of studies reporting on experiences of Covid-19 restrictions have been in the context of more substantial mandatory

Understanding the molecular mechanisms of osteoarthritis (OA) is critical for early diagnosis and effective treatment. OA is a leading cause of disability and poses an increasing burden on healthcare systems, particularly with an aging global population. Despite the potential of proteomics to elucidate the complex biology underlying OA, its application remains limited due to challenges including g

Tendons are collagen-based connective tissues where the composition, structure and mechanics respond and adapt to the local mechanical environment. Adaptation to prolonged inactivity can result in stiffer tendons that are more prone to injury. However, the complex relation between reduced loading, structure, and mechanical performance is still not fully understood. This study combines mechanical t

Collagen is the main organic building block of musculoskeletal tissues. Despite collagen being their smallest load bearing unit, these tissues differ significantly in mechanical function and properties. A major factor behind these differences is their hierarchical organization, from the collagen molecule up to the organ scale. It is thus of high importance to understand the characteristics of each